Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain von Dzierba, Carolyn D., Dasgupta, Bireshwar, Karageorge, George, Kostich, Walter, Hamman, Brian, Allen, Jason, Esposito, Kim M., Padmanabha, Ramesh, Grace, James, Lentz, Kimberley, Morrison, John, Morgan, Daniel, Easton, Amy, Bourin, Clotilde, Browning, Marc R., Rajamani, Ramkumar, Good, Andrew, Parker, Dawn D., Muckelbauer, Jodi K., Khan, Javed, Camac, Daniel, Ghosh, Kaushik, Halan, Vivek, Lippy, Jonathan S., Santone, Kenneth S., Denton, R. Rex, Westphal, Ryan, Bristow, Linda J., Conway, Charles M., Bronson, Joanne J., Macor, John E.

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Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy von Li, Yu-Wen, Seager, Matthew A., Wojcik, Trevor, Heman, Karen, Molski, Thaddeus F., Fernandes, Alda, Langdon, Shaun, Pendri, Annapurna, Gerritz, Samuel, Tian, Yuan, Hong, Yang, Gallagher, Lizbeth, Merritt, James R., Zhang, Chongwu, Westphal, Ryan, Zaczek, Robert, Macor, John E., Bronson, Joanne J., Lodge, Nicholas J.

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Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88 von Dzierba, Carolyn D., Bi, Yingzhi, Dasgupta, Bireshwar, Hartz, Richard A., Ahuja, Vijay, Cianchetta, Giovanni, Kumi, Godwin, Dong, Li, Aleem, Saadat, Fink, Cynthia, Garcia, Yudith, Green, Michael, Han, Jianxin, Kwon, Soojin, Qiao, Ying, Wang, Jiancheng, Zhang, Yulian, Liu, Ying, Zipp, Greg, Liang, Zhi, Burford, Neil, Ferrante, Meredith, Bertekap, Robert, Lewis, Martin, Cacace, Angela, Grace, James, Wilson, Alan, Nouraldeen, Amr, Westphal, Ryan, Kimball, David, Carson, Kenneth, Bronson, Joanne J., Macor, John E.

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The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders von Bi, Yingzhi, Dzierba, Carolyn D., Fink, Cynthia, Garcia, Yudith, Green, Michael, Han, Jianxin, Kwon, Soojin, Kumi, Godwin, Liang, Zhi, Liu, Ying, Qiao, Ying, Zhang, Yulian, Zipp, Greg, Burford, Neil, Ferrante, Meredith, Bertekap, Robert, Lewis, Martin, Cacace, Angela, Westphal, Ryan S., Kimball, David, Bronson, Joanne J., Macor, John E.

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Synthesis and evaluation of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 (CRF1) receptor antagonists von Ahuja, Vijay T., Hartz, Richard A., Molski, Thaddeus F., Mattson, Gail K., Lentz, Kimberley A., Grace, James E., Lodge, Nicholas J., Bronson, Joanne J., Macor, John E.

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Antimicrobial Evaluation of Nocathiacins, a Thiazole Peptide Class of Antibiotics von PUCCI, Michael J, BRONSON, Joanne J, BARRETT, John F, DENBLEYKER, Kenneth L, DISCOTTO, Linda F, FUNG-TOMC, Joan C, UEDA, Yasutsugu

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Synthesis and evaluation of candidate PET radioligands for corticotropin-releasing factor type-1 receptors von Lodge, Nicholas J, Li, Yu-Wen, Chin, Frederick T, Dischino, Douglas D, Zoghbi, Sami S, Deskus, Jeffrey A, Mattson, Ronald J, Imaizumi, Masao, Pieschl, Rick, Molski, Thaddeus F, Fujita, Masahiro, Dulac, Heidi, Zaczek, Robert, Bronson, Joanne J, Macor, John E, Innis, Robert B, Pike, Victor W

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Pharmacological and behavioral characterization of the novel CRF1 antagonist BMS-763534 von Lodge, Nicholas J., Lelas, Snjezana, Li, Yu-Wen, Molski, Thaddeus, Grace, James, Sivarao, Digavalli V., Post-Munson, Debra, Healy, Francine, Bronson, Joanne J., Hartz, Richard, Macor, John E., Zaczek, Robert

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Discovery, Structure–Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2‑Associated Kinase 1 (AAK1) Inhibitors for the Treatmen... von Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C.M. Vijaya, Brown, Jeffrey M, Bristow, Linda J, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel, Kiefer, Susan E, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Easton, Amy, Lippy, Jonathan S, Surti, Neha, Pattipati, Sreenivasulu N, Dokania, Manoj, Elavazhagan, Saravanan, Dandapani, Kumaran, Hamman, Brian D, Allen, Jason, Kostich, Walter, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D

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Comparative Biotransformation of Pyrazinone-Containing Corticotropin-Releasing Factor Receptor-1 Antagonists: Minimizing the Reactive Metabolite Formation von XIAOLIANG ZHUO, HARTZ, Richard A, BRONSON, Joanne J, WONG, Harvey, AHUJA, Vijay T, VRUDHULA, Vivekananda M, LEET, John E, HUANG, Stella, MACOR, John E, SHU, Yue-Zhong

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Empowering Voices: Inspiring Women in Medicinal Chemistry von Blanco, Maria-Jesus, Bronson, Joanne J., DiMauro, Erin F., Dzierba, Carolyn, Eggen, MariJean, Garner, Amanda L., Georg, Gunda, Giarolla, Jeanine, Goodwin, Nicole C., Grenier-Davies, Melissa C., Haskell-Luevano, Carrie, Holzgrabe, Ulrike, Huang, Rong, Lagiakos, H. Rachel, Leftheris, Katerina, Martin, Yvonne, Matos, Maria João, May-Dracka, Tricia L., Müller, Christa E., Newman, Amy H., Parmee, Emma, Petter, Jennifer C., Tamayo, Nuria A., Wexler, Ruth R., Bolognesi, Maria Laura, Ripka, Amy, Young, Wendy

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Discovery of (S)‑1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adap... von Luo, Guanglin, Chen, Ling, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Maishal, Tarun Kumar, Thiyagarajan, Kamalraj, Jalagam, Prasadrao, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Das, Manish Lal, Wagh, Santosh, Balakrishnan, Anand, Johnson, Benjamin M., Santone, Kenneth S., Thalody, George, Denton, Rex, Saminathan, Hariharan, Holenarsipur, Vinay K., Kumar, Anoop, Rao, Abhijith, Putlur, Siva Prasad, Sarvasiddhi, Sarat Kumar, Shankar, Ganesh, Louis, Justin V., Ramarao, Manjunath, Conway, Charles M., Li, Yu-Wen, Pieschl, Rick, Tian, Yuan, Hong, Yang, Ditta, Jonathan, Mathur, Arvind, Li, Jianqing, Smith, Daniel, Pawluczyk, Joseph, Sun, Dawn, Yip, Shiuhang, Wu, Dauh-Rurng, Vetrichelvan, Muthalagu, Gupta, Anuradha, Wilson, Alan, Gopinathan, Suma, Wason, Suman, Bristow, Linda, Albright, Charles F., Bronson, Joanne J., Macor, John E., Dzierba, Carolyn D.

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Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2‑Associated Kinase 1 Inhibitors von Hartz, Richard A, Ahuja, Vijay T, Nara, Susheel J, Kumar, C. M. Vijaya, Manepalli, Raju K. V. L. P, Sarvasiddhi, Sarat Kumar, Honkhambe, Swarnamba, Patankar, Vidya, Dasgupta, Bireshwar, Rajamani, Ramkumar, Muckelbauer, Jodi K, Camac, Daniel M, Ghosh, Kaushik, Pokross, Matthew, Kiefer, Susan E, Brown, Jeffrey M, Hunihan, Lisa, Gulianello, Michael, Lewis, Martin, Lippy, Jonathan S, Surti, Neha, Hamman, Brian D, Allen, Jason, Kostich, Walter A, Bronson, Joanne J, Macor, John E, Dzierba, Carolyn D

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Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors fo... von Luo, Guanglin, Chen, Ling, Kostich, Walter A., Hamman, Brian, Allen, Jason, Easton, Amy, Bourin, Clotilde, Gulianello, Michael, Lippy, Jonathan, Nara, Susheel, Pattipati, Sreenivasulu Naidu, Dandapani, Kumaran, Dokania, Manoj, Vattikundala, Pradeep, Sharma, Vivek, Elavazhagan, Saravanan, Verma, Manoj Kumar, Lal Das, Manish, Wagh, Santosh, Balakrishnan, Anand, Johnson, Benjamin M., Santone, Kenneth S., Thalody, George, Denton, Rex, Saminathan, Hariharan, Holenarsipur, Vinay K., Kumar, Anoop, Rao, Abhijith, Putlur, Siva Prasad, Sarvasiddhi, Sarat Kumar, Shankar, Ganesh, Louis, Justin V., Ramarao, Manjunath, Conway, Charles M., Li, Yu-Wen, Pieschl, Rick, Tian, Yuan, Hong, Yang, Bristow, Linda, Albright, Charles F., Bronson, Joanne J., Macor, John E., Dzierba, Carolyn D.

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Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box von Huang, Hong, Degnan, Andrew P., Balakrishnan, Anand, Easton, Amy, Gulianello, Michael, Huang, Yanling, Matchett, Michele, Mattson, Gail, Miller, Regina, Santone, Kenneth S., Senapati, Arun, Shields, Eric E., Sivarao, Digavalli V., Snyder, Lawrence B., Westphal, Ryan, Whiterock, Valerie J., Yang, Fukang, Bronson, Joanne J., Macor, John E.

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Empowering Voices: Inspiring Women in Medicinal Chemistry von Blanco, Maria-Jesus, Bronson, Joanne J., DiMauro, Erin F., Dzierba, Carolyn, Eggen, MariJean, Garner, Amanda L., Georg, Gunda, Giarolla, Jeanine, Goodwin, Nicole C., Grenier-Davies, Melissa C., Haskell-Luevano, Carrie, Holzgrabe, Ulrike, Huang, Rong, Lagiakos, H. Rachel, Leftheris, Katerina, Martin, Yvonne, Matos, Maria João, May-Dracka, Tricia L., Müller, Christa E., Newman, Amy H., Parmee, Emma, Petter, Jennifer C., Tamayo, Nuria A., Wexler, Ruth R., Bolognesi, Maria Laura, Ripka, Amy, Young, Wendy

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Discovery and characterization of N-(1,3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4,3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction... von Engers, Darren W., Bollinger, Sean R., Engers, Julie L., Panarese, Joseph D., Breiner, Megan M., Gregro, Alison, Blobaum, Anna L., Bronson, Joanne J., Wu, Yong-Jin, Macor, John E., Rodriguez, Alice L., Zamorano, Rocio, Conn, P. Jeffrey, Lindsley, Craig W., Niswender, Colleen M., Hopkins, Corey R.

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Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl... von Bristow, Linda J., Gulia, Jyoti, Weed, Michael R., Srikumar, Bettadapura N., Li, Yu-Wen, Graef, John D., Naidu, Pattipati S., Sanmathi, Charulatha, Aher, Jayant, Bastia, Tanmaya, Paschapur, Mahesh, Kalidindi, Narasimharaju, Kumar, Kuchibhotla Vijaya, Molski, Thaddeus, Pieschl, Rick, Fernandes, Alda, Brown, Jeffrey M., Sivarao, Digavalli V., Newberry, Kimberly, Bookbinder, Mark, Polino, Joseph, Keavy, Deborah, Newton, Amy, Shields, Eric, Simmermacher, Jean, Kempson, James, Li, Jianqing, Zhang, Huiping, Mathur, Arvind, Kallem, Raja Reddy, Sinha, Meenakshee, Ramarao, Manjunath, Vikramadithyan, Reeba K., Thangathirupathy, Srinivasan, Warrier, Jayakumar, Islam, Imadul, Bronson, Joanne J., Olson, Richard E., Macor, John E., Albright, Charlie F., King, Dalton, Thompson, Lorin A., Marcin, Lawrence R., Sinz, Michael

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The discovery of VU0652957 (VU2957, Valiglurax): SAR and DMPK challenges en route to an mGlu4 PAM development candidate von Panarese, Joseph D., Engers, Darren W., Wu, Yong-Jin, Guernon, Jason M., Chun, Aspen, Gregro, Alison R., Bender, Aaron M., Capstick, Rory A., Wieting, Joshua M., Bronson, Joanne J., Macor, John E., Westphal, Ryan, Soars, Matthew, Engers, Julie E., Felts, Andrew S., Rodriguez, Alice L., Emmitte, Kyle A., Jones, Carrie K., Blobaum, Anna L., Jeffrey Conn, P., Niswender, Colleen M., Hopkins, Corey R., Lindsley, Craig W.

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Discovery, Synthesis, and Preclinical Characterization of N‑(3-Chloro-4-fluorophenyl)‑1H‑pyrazolo[4,3‑b]pyridin-3-amine (VU0418506), a Novel Positive Allosteric Modulator of the Me... von Engers, Darren W, Blobaum, Anna L, Gogliotti, Rocco D, Cheung, Yiu-Yin, Salovich, James M, Garcia-Barrantes, Pedro M, Daniels, J. Scott, Morrison, Ryan, Jones, Carrie K, Soars, Matthew G, Zhuo, Xiaoliang, Hurley, Jeremy, Macor, John E, Bronson, Joanne J, Conn, P. Jeffrey, Lindsley, Craig W, Niswender, Colleen M, Hopkins, Corey R

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