Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance von Salami, Jemilat, Alabi, Shanique, Willard, Ryan R., Vitale, Nick J., Wang, Jing, Dong, Hanqing, Jin, Meizhong, McDonnell, Donald P., Crew, Andrew P., Neklesa, Taavi K., Crews, Craig M.

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A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes von Li, An-Hu, Ahmed, Eilaf, Chen, Xin, Cox, Matthew, Crew, Andrew P, Dong, Han-Qing, Jin, Meizhong, Ma, Lifu, Panicker, Bijoy, Siu, Kam W, Steinig, Arno G, Stolz, Kathryn M, Tavares, Paula A R, Volk, Brian, Weng, Qinghua, Werner, Doug, Mulvihill, Mark J

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Modulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: current status and future perspectives von Jin, Meizhong, Buck, Elizabeth, Mulvihill, Mark J

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Imidazo[1,5- a]pyrazines: Orally efficacious inhibitors of mTORC1 and mTORC2 von Crew, Andrew P., Bhagwat, Shripad V., Dong, Hanqing, Bittner, Mark A., Chan, Anna, Chen, Xin, Coate, Heather, Cooke, Andrew, Gokhale, Prafulla C., Honda, Ayako, Jin, Meizhong, Kahler, Jennifer, Mantis, Christine, Mulvihill, Mark J., Tavares-Greco, Paula A., Volk, Brian, Wang, Jing, Werner, Douglas S., Arnold, Lee D., Pachter, Jonathan A., Wild, Robert, Gibson, Neil W.

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Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy von Jin, Meizhong, Kleinberg, Andrew, Cooke, Andy, Gokhale, Prafulla C., Foreman, Kenneth, Dong, Hanqing, Siu, Kam W., Bittner, Mark A., Mulvihill, Kristen M., Yao, Yan, Landfair, Darla, O’Connor, Matthew, Mak, Gilda, Pachter, Jonathan A., Wild, Robert, Rosenfeld-Franklin, Maryland, Ji, Qunsheng, Mulvihill, Mark J.

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Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl‑b Inhibitors von Mfuh, Adelphe M., Boerth, Jeffrey A., Bommakanti, Gayathri, Chan, Christina, Chinn, Alex J., Code, Erin, Fricke, Patrick J., Giblin, Kathryn A., Gohlke, Andrea, Hansel, Catherine, Hariparsad, Niresh, Hughes, Samantha J., Jin, Meizhong, Kantae, Vasudev, Kavanagh, Stefan L., Lamb, Michelle L., Lane, Jordan, Moore, Rachel, Puri, Taranee, Quinn, Taylor R., Reddy, Iswarya, Robb, Graeme R., Robbins, Kevin J., Gancedo Rodrigo, Miguel, Schimpl, Marianne, Singh, Baljinder, Singh, Meha, Tang, Haoran, Thomson, Clare, Walsh, Jarrod J., Ware, Jamie, Watson, Iain D. G., Ye, Min-Wei, Wrigley, Gail L., Zhang, Andrew X., Zhang, Yun, Grimster, Neil P.

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Abstract A06: Biophysical and biochemical characterization of KRAS G12C inhibition through the SMARTTM platform von Zhou, Minyun, Yuzhakov, Alexander, Benod, Cindy C, Xue, Linlong, Silver, Alec D, Iyer, Ganesh, Townson, Sharon A., Jin, Meizhong, Perl, Nicholas R., Kohlmann, Anna, Mann, Alan S., Akcay, Gizem, May, Earl W.

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Abstract B37: Development of inhibitors of the activated form of KRAS G12C von Stewart, Michelle L., Perl, Nicholas R., Lee, Seung-Joo, Xue, Linlong, Zhou, Minyun, Simon, Jonah, Luly, Kathryn M., Grigoriu, Siminia, Yuzhakov, Alex, Silver, Alec, Lowe, Jason T., Benod, Cindy C., Mann, Alan S., Verdine, Gregory L., Rigby, Alan C., Mulvihill, Mark J., May, Earl W., Kohlmann, Anna, Townson, Sharon A., Pollock, Roy M., Jin, Meizhong

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Discovery of a Novel Benzodiazepine Series of Cbl‑b Inhibitors for the Enhancement of Antitumor Immunity von Boerth, Jeffrey A., Chinn, Alex J., Schimpl, Marianne, Bommakanti, Gayathri, Chan, Christina, Code, Erin L., Giblin, Kathryn A., Gohlke, Andrea, Hansel, Catherine S., Jin, Meizhong, Kavanagh, Stefan L., Lamb, Michelle L., Lane, Jordan S., Larner, Carrie J. B., Mfuh, Adelphe M., Moore, Rachel K., Puri, Taranee, Quinn, Taylor R., Ye, Minwei, Robbins, Kevin J., Gancedo-Rodrigo, Miguel, Tang, Haoran, Walsh, Jarrod, Ware, Jamie, Wrigley, Gail L., Reddy, Iswarya Karapa, Zhang, Yun, Grimster, Neil P.

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Total Synthesis of (+)-Peloruside A von Jin, Meizhong, Taylor, Richard E

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Palladium-Catalyzed Direct Heck Arylation of Dual π-Deficient/π-Excessive Heteroaromatics. Synthesis of C-5 Arylated Imidazo[1,5-a]pyrazines von Wang, Jian-Xin, McCubbin, J. Adam, Jin, Meizhong, Laufer, Radoslaw S, Mao, Yunyu, Crew, Andrew P, Mulvihill, Mark J, Snieckus, Victor

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ARV-330: Androgen receptor PROTAC degrader for prostate cancer von Neklesa, Taavi K, Jin, Meizhong, Crew, Andrew P, Rossi, AnnMarie K, Willard, Ryan R, Dong, Hanqing, Siu, Kam, Wang, Jing, Gordon, Deborah A, Chen, Xin, Ferraro, Caterina, Crews, Craig M, Coleman, Kevin, Winkler, James D.

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Abstract LB-097: Targeted degradation of the androgen receptor in prostate cancer von Jin, Meizhong, Winkler, James D., Coleman, Kevin, Crew, Andrew P., Rossi, AnnMarie K., Willard, Ryan R., Dong, Hanqing, Siu, Kam, Wang, Jing, Gordon, Deborah A., Chen, Xin, Ferraro, Caterina, Crews, Craig M., Neklesa, Taavi K.

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Abstract PR08: ARV-330: An androgen receptor PROTAC degrader for prostate cancer von Winkler, James D., Jin, Meizhong, Crew, Andy P., Rossi, AnnMarie K., Willard, Ryan R., Dong, Hanqing, Siu, Kam, Wang, Jing, Gordon, Deborah A., Chen, Xin, Ferraro, Caterina, Crews, Craig M., Coleman, Kevin, Neklesa, Taavi K.

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Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors von Jin, Meizhong, Wang, Jing, Kleinberg, Andrew, Kadalbajoo, Mridula, Siu, Kam W., Cooke, Andrew, Bittner, Mark A., Yao, Yan, Thelemann, April, Ji, Qunsheng, Bhagwat, Shripad, Mulvihill, Kristen M., Rechka, Josef A., Pachter, Jonathan A., Crew, Andrew P., Epstein, David, Mulvihill, Mark J.

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Toward a Total Synthesis of Peloruside A:  Enantioselective Preparation of the C8−C19 Region von Taylor, Richard E, Jin, Meizhong

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Modulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: Current status and future perspectives von Meizhong Jin, Elizabeth Buck, Mark J. Mulvihill

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Abstract 2463: Discovery of imidazo[1,5- a ]pyrazine derived potent, selective and orally bioavailable ACK1 inhibitors von Jin, Meizhong, Wang, Jing, Kleinberg, Andrew, Kadalbajoo, Mridula, Siu, Kam W., Cooke, Andrew, Bittner, Mark, Yao, Yan, Thelemann, April, Ji, Qunsheng, Bhagwat, Shripad, Mulvihill, Kristen M., Rechka, Josef A., Pachter, Jonathan A., Crew, Andrew P., Epstein, David, Mulvihill, Mark J.

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Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases von Steinig, Arno G., Li, An-Hu, Wang, Jing, Chen, Xin, Dong, Hanqing, Ferraro, Caterina, Jin, Meizhong, Kadalbajoo, Mridula, Kleinberg, Andrew, Stolz, Kathryn M., Tavares-Greco, Paula A., Wang, Ti, Albertella, Mark R., Peng, Yue, Crew, Linda, Kahler, Jennifer, Kan, Julie, Schulz, Ryan, Cooke, Andy, Bittner, Mark, Turton, Roy W., Franklin, Maryland, Gokhale, Prafulla, Landfair, Darla, Mantis, Christine, Workman, Jen, Wild, Robert, Pachter, Jonathan, Epstein, David, Mulvihill, Mark J.

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Modulation of insulin-like growth factor-1 receptor and its signaling network for the treatment of cancer: current status and future perspectives von Jin, Meizhong, Buck, Elizabeth, Mulvihill, Mark J.

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