Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C von Weiss, Andreas, Lorthiois, Edwige, Barys, Louise, Beyer, Kim S, Bomio-Confaglia, Claudio, Burks, Heather, Chen, Xueying, Cui, Xiaoming, de Kanter, Ruben, Dharmarajan, Lekshmi, Fedele, Carmine, Gerspacher, Marc, Guthy, Daniel Alexander, Head, Victoria, Jaeger, Ashley, Núñez, Eloísa Jiménez, Kearns, Jeffrey D, Leblanc, Catherine, Maira, Sauveur-Michel, Murphy, Jason, Oakman, Helen, Ostermann, Nils, Ottl, Johannes, Rigollier, Pascal, Roman, Danielle, Schnell, Christian, Sedrani, Richard, Shimizu, Toshio, Stringer, Rowan, Vaupel, Andrea, Voshol, Hans, Wessels, Peter, Widmer, Toni, Wilcken, Rainer, Xu, Kun, Zecri, Frederic, Farago, Anna F, Cotesta, Simona, Brachmann, Saskia M

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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers von Ferretti, Stephane, Hamon, Jacques, de Kanter, Ruben, Scheufler, Clemens, Andraos-Rey, Rita, Barbe, Stephanie, Bechter, Elisabeth, Blank, Jutta, Bordas, Vincent, Dammassa, Ernesta, Decker, Andrea, Di Nanni, Noemi, Dourdoigne, Marion, Gavioli, Elena, Hattenberger, Marc, Heuser, Alisa, Hemmerlin, Christelle, Hinrichs, Jürgen, Kerr, Grainne, Laborde, Laurent, Jaco, Isabel, Núñez, Eloísa Jiménez, Martus, Hans-Joerg, Quadt, Cornelia, Reschke, Markus, Romanet, Vincent, Schaeffer, Fanny, Schoepfer, Joseph, Schrapp, Maxime, Strang, Ross, Voshol, Hans, Wartmann, Markus, Welly, Sarah, Zécri, Frédéric, Hofmann, Francesco, Möbitz, Henrik, Cortés-Cros, Marta

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Abstract P124: JDQ443, a covalent irreversible inhibitor of KRAS G12C, exhibits a novel binding mode and demonstrates potent anti-tumor activity and favorable pharmacokinetic prope... von Brachmann, Saskia M., Weiss, Andreas, Guthy, Daniel A., Beyer, Kim, Voshol, Johannes, Maira, Michel, Prahallad, Anirudh, Porta, Diana Graus, Schnell, Christian, Ostermann, Nils, Vaupel, Andrea, Gerspacher, Marc, Leblanc, Catherine, Erdmann, Dirk, Sterker, Dario, Kerr, Grainne, Jerome, Giovannoni, Head, Victoria, Stringer, Rowan, De Kanter, Ruben, Jeff, Kearns, Roman, Danielle, Widmer, Toni, Wessels, Peter, Nunez, Eloisa Jimenez, Sedrani, Richard, Zecri, Frederic, Hofmann, Francesco, Engleman, Jeff, Lorthiois, Edwige, Cotesta, Simona

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Prins Cyclizations in Au-Catalyzed Reactions of Enynes von Jiménez-Núñez, Eloísa, Claverie, Christelle K., Nieto-Oberhuber, Cristina, Echavarren, Antonio M.

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Abstract PR007: Discovery of HRO761, a novel, first-in-class clinical stage WRN inhibitor with potent and selective anti-tumor activity in cancers with microsatellite instability von Cortes-Cros, Marta, Moebitz, Henrik, Barbe, Stephanie, Blank, Jutta, Bordas, Vincent, Clementi, Giorgia, Dammassa, Ernesta, Decker, Andrea, Nanni, Noemi Di, de Kanter, Ruben, Dourdoigne, Marion, Gavioli, Elena, Ferretti, Stephane, Hattenberger, Marc, Hemmerlin, Christelle, Hamon, Jacques, Hinrichs, Juergen, Jaco, Isabel, Jankovic, Dragana, Nunez, Eloisa Jimenez, Li, Yifang, Martus, Hans-Joerg, Moschetta, Michele, Quadt, Cornelia, Reschke, Markus, Romanet, Vincent, Scheufler, Clemens, Schoepfer, Joseph, Strang, Ross, Therier, Maxime, Voshol, Hans, Wartmann, Markus, Welly, Sarah, Pham, Monica, Laborde, Laurent

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Abstract LB319: IAG933, a selective and orally efficacious YAP1/WWTR1(TAZ)-panTEAD protein-protein interaction inhibitor with pre-clinical activity in monotherapy and combinations von Schmelzle, Tobias, Chapeau, Emilie, Bauer, Daniel, Chene, Patrick, Faris, Jason, Fernandez, Cesar, Furet, Pascal, Galli, Giorgio, Gong, Jiachang, Harlfinger, Stephanie, Hofmann, Francesco, Nunez, Eloisa Jimenez, Kallen, Joerg, Mourikis, Thanos, Sansregret, Laurent, Santos, Paulo, Scheufler, Clemens, Sellner, Holger, Voegtle, Markus, Wartmann, Markus, Wessels, Peter, Zecri, Frederic, Soldermann, Nicolas

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Stereoselective gold-catalyzed cycloaddition of functionalized ketoenynes: synthesis of (+)-orientalol F von Jiménez-Núñez, Eloísa, Molawi, Kian, Echavarren, Antonio M

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Evolution of Propargyl Ethers into Allylgold Cations in the Cyclization of Enynes von Jiménez-Núñez, Eloísa, Raducan, Mihai, Lauterbach, Thorsten, Molawi, Kian, Solorio, César R, Echavarren, Antonio M

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Gold(I)-Catalyzed Cyclizations of 1,6-Enynes: Alkoxycyclizations and exo/endo Skeletal Rearrangements von Nieto-Oberhuber, Cristina, Muñoz, M. Paz, López, Salomé, Jiménez-Núñez, Eloísa, Nevado, Cristina, Herrero-Gómez, Elena, Raducan, Mihai, Echavarren, Antonio M.

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On the Mechanism of the Puzzling "Endocyclic" Skeletal Rearrangement of 1,6-Enynes von Cabello, Noemí, Jiménez-Núñez, Eloísa, Buñuel, Elena, Cárdenas, Diego J., Echavarren, Antonio M.

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ChemInform Abstract: Gold-Catalyzed Cycloisomerizations of Enynes: A Mechanistic Perspective von Jimenez-Nunez, Eloisa, Echavarren, Antonio M.

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Gold(I)-Catalyzed Intramolecular Cyclopropanation of Dienynes von Nieto-Oberhuber, Cristina, López, Salomé, Muñoz, M. Paz, Jiménez-Núñez, Eloísa, Buñuel, Elena, Cárdenas, Diego J., Echavarren, Antonio M.

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ChemInform Abstract: Evolution of Propargyl Ethers into Allylgold Cations in the Cyclization of Enynes von Jimenez-Nunez, Eloisa, Reducan, Mihai, Lauterbach, Thorsten, Molawi, Kian, Solorio, Cesar R., Echavarren, Antonio M.

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Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers von Chapeau, Emilie A, Sansregret, Laurent, Galli, Giorgio G, Chène, Patrick, Wartmann, Markus, Mourikis, Thanos P, Jaaks, Patricia, Baltschukat, Sabrina, Barbosa, Ines A M, Bauer, Daniel, Brachmann, Saskia M, Delaunay, Clara, Estadieu, Claire, Faris, Jason E, Furet, Pascal, Harlfinger, Stefanie, Hueber, Andreas, Jiménez Núñez, Eloísa, Kodack, David P, Mandon, Emeline, Martin, Typhaine, Mesrouze, Yannick, Romanet, Vincent, Scheufler, Clemens, Sellner, Holger, Stamm, Christelle, Sterker, Dario, Tordella, Luca, Hofmann, Francesco, Soldermann, Nicolas, Schmelzle, Tobias

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Gold(I)-Catalyzed Intramolecular Cyclopropanation of Dienynes von Nieto-Oberhuber, Cristina, Lopez, Salome, Munoz, M. Paz, Jimenez-Nunez, Eloisa, Bunuel, Elena, Cardenas, Diego J., Echavarren, Antonio M.

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Gold(I)-Catalyzed Cyclizations of 1,6-Enynes: Alkoxycyclizations and exo/endo Skeletal Rearrangements von Nieto-Oberhuber, Cristina, Munoz, M. Paz, Lopez, Salome, Jimenez-Nunez, Eloisa, Nevado, Cristina, Herrero-Gomez, Elena, Raducan, Mihai, Echavarren, Antonio M.

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SUBSTITUTED OXOPYRIDINE DERIVATIVES von ADRIAN TERSTEEGEN, STEFAN HEITMEIER, KATHARINA MEIER, ELOISA JIMENEZ NUNEZ, ALEXANDER HILLISCH, PASCAL ELLERBROCK, DANIEL MEIBOM, SUSANNE ROHRIG, ACKERSTAFF, JENS, DIETER LANG, JAN STAMPFU?

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SUBSTITUTED OXOPYRIDINE DERIVATIVES von TERSTEEGEN, Adrian, MEIBOM, Daniel, JIMENEZ NUNEZ, Eloisa, HILLISCH, Alexander, HEITMEIER, Stefan, ELLERBROCK, Pascal, STAMPFUSS, Jan, ACKERSTAFF, Jens, ROEHRIG, Susanne, MEIER, Katharina, LANG, Dieter

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Substituted oxopyridine derivatives von Heitmeier, Stefan, Stampfuss, Jan, Roehrig, Susanne, Tersteegen, Adrian, Ackerstaff, Jens, Meibom, Daniel, Jimenez Nunez, Eloisa, Ellerbrock, Pascal, Lang, Dieter, Hillisch, Alexander, Meier, Katharina

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SUBSTITUTED OXOPYRIDINE DERIVATIVES von TERSTEEGEN, Adrian, MEIBOM, Daniel, JIMENEZ NUNEZ, Eloisa, HILLISCH, Alexander, HEITMEIER, Stefan, ELLERBROCK, Pascal, STAMPFUSS, Jan, ACKERSTAFF, Jens, ROEHRIG, Susanne, MEIER, Katharina, LANG, Dieter

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