Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C von Weiss, Andreas, Lorthiois, Edwige, Barys, Louise, Beyer, Kim S, Bomio-Confaglia, Claudio, Burks, Heather, Chen, Xueying, Cui, Xiaoming, de Kanter, Ruben, Dharmarajan, Lekshmi, Fedele, Carmine, Gerspacher, Marc, Guthy, Daniel Alexander, Head, Victoria, Jaeger, Ashley, Núñez, Eloísa Jiménez, Kearns, Jeffrey D, Leblanc, Catherine, Maira, Sauveur-Michel, Murphy, Jason, Oakman, Helen, Ostermann, Nils, Ottl, Johannes, Rigollier, Pascal, Roman, Danielle, Schnell, Christian, Sedrani, Richard, Shimizu, Toshio, Stringer, Rowan, Vaupel, Andrea, Voshol, Hans, Wessels, Peter, Widmer, Toni, Wilcken, Rainer, Xu, Kun, Zecri, Frederic, Farago, Anna F, Cotesta, Simona, Brachmann, Saskia M

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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers von Ferretti, Stephane, Hamon, Jacques, de Kanter, Ruben, Scheufler, Clemens, Andraos-Rey, Rita, Barbe, Stephanie, Bechter, Elisabeth, Blank, Jutta, Bordas, Vincent, Dammassa, Ernesta, Decker, Andrea, Di Nanni, Noemi, Dourdoigne, Marion, Gavioli, Elena, Hattenberger, Marc, Heuser, Alisa, Hemmerlin, Christelle, Hinrichs, Jürgen, Kerr, Grainne, Laborde, Laurent, Jaco, Isabel, Núñez, Eloísa Jiménez, Martus, Hans-Joerg, Quadt, Cornelia, Reschke, Markus, Romanet, Vincent, Schaeffer, Fanny, Schoepfer, Joseph, Schrapp, Maxime, Strang, Ross, Voshol, Hans, Wartmann, Markus, Welly, Sarah, Zécri, Frédéric, Hofmann, Francesco, Möbitz, Henrik, Cortés-Cros, Marta

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Gold-Catalyzed Cycloisomerizations of Enynes: A Mechanistic Perspective von Jiménez-Núñez, Eloísa, Echavarren, Antonio M

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Abstract P124: JDQ443, a covalent irreversible inhibitor of KRAS G12C, exhibits a novel binding mode and demonstrates potent anti-tumor activity and favorable pharmacokinetic prope... von Brachmann, Saskia M., Weiss, Andreas, Guthy, Daniel A., Beyer, Kim, Voshol, Johannes, Maira, Michel, Prahallad, Anirudh, Porta, Diana Graus, Schnell, Christian, Ostermann, Nils, Vaupel, Andrea, Gerspacher, Marc, Leblanc, Catherine, Erdmann, Dirk, Sterker, Dario, Kerr, Grainne, Jerome, Giovannoni, Head, Victoria, Stringer, Rowan, De Kanter, Ruben, Jeff, Kearns, Roman, Danielle, Widmer, Toni, Wessels, Peter, Nunez, Eloisa Jimenez, Sedrani, Richard, Zecri, Frederic, Hofmann, Francesco, Engleman, Jeff, Lorthiois, Edwige, Cotesta, Simona

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The Mechanistic Puzzle of Transition-Metal-Catalyzed Skeletal Rearrangements of Enynes von Nieto-Oberhuber, Cristina, López, Salomé, Jiménez-Núñez, Eloísa, Echavarren, Antonio M.

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Prins Cyclizations in Au-Catalyzed Reactions of Enynes von Jiménez-Núñez, Eloísa, Claverie, Christelle K., Nieto-Oberhuber, Cristina, Echavarren, Antonio M.

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Abstract B143: HRO761, a first-in-class, clinical stage WRN inhibitor with potent preclinical anti-tumor activity in MSIhigh models von Ferretti, Stephane, Jaco, Isabel, Decker, Andrea, Hemmerlin, Christelle, Scheufler, Clemens, Quadt, Cornelia, Sterker, Dario, Gavioli, Elena, Nunez, Eloisa Jimenez, Dammassa, Ernesta, Schaeffer, Fanny, Albrecht, Genevieve, Clementi, Giorgia, Martus, Hansjoerg, Hamon, Jacques, Hinrichs, Juergen, Laborde, Laurent, Dourdoigne, Marion, Moschetta, Michele, Stump, Ramona, Andraos-Rey, Rita, Welly, Sarah, Barbe, Stephanie, Romanet, Vincent, Reschke, Markus, Kanter, Ruben De, Jensen, Michael, Moebitz, Henrik, Cros, Marta Cortes

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Abstract PR007: Discovery of HRO761, a novel, first-in-class clinical stage WRN inhibitor with potent and selective anti-tumor activity in cancers with microsatellite instability von Cortes-Cros, Marta, Moebitz, Henrik, Barbe, Stephanie, Blank, Jutta, Bordas, Vincent, Clementi, Giorgia, Dammassa, Ernesta, Decker, Andrea, Nanni, Noemi Di, de Kanter, Ruben, Dourdoigne, Marion, Gavioli, Elena, Ferretti, Stephane, Hattenberger, Marc, Hemmerlin, Christelle, Hamon, Jacques, Hinrichs, Juergen, Jaco, Isabel, Jankovic, Dragana, Nunez, Eloisa Jimenez, Li, Yifang, Martus, Hans-Joerg, Moschetta, Michele, Quadt, Cornelia, Reschke, Markus, Romanet, Vincent, Scheufler, Clemens, Schoepfer, Joseph, Strang, Ross, Therier, Maxime, Voshol, Hans, Wartmann, Markus, Welly, Sarah, Pham, Monica, Laborde, Laurent

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Abstract LB319: IAG933, a selective and orally efficacious YAP1/WWTR1(TAZ)-panTEAD protein-protein interaction inhibitor with pre-clinical activity in monotherapy and combinations von Schmelzle, Tobias, Chapeau, Emilie, Bauer, Daniel, Chene, Patrick, Faris, Jason, Fernandez, Cesar, Furet, Pascal, Galli, Giorgio, Gong, Jiachang, Harlfinger, Stephanie, Hofmann, Francesco, Nunez, Eloisa Jimenez, Kallen, Joerg, Mourikis, Thanos, Sansregret, Laurent, Santos, Paulo, Scheufler, Clemens, Sellner, Holger, Voegtle, Markus, Wartmann, Markus, Wessels, Peter, Zecri, Frederic, Soldermann, Nicolas

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Structure-Based and Property-Driven Optimization of N‑Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors von Hoegenauer, Klemens, Kallen, Joerg, Jiménez-Núñez, Eloísa, Strang, Ross, Ertl, Peter, Cooke, Nigel G, Hintermann, Samuel, Voegtle, Markus, Betschart, Claudia, McKay, Daniel J. J, Wagner, Juergen, Ottl, Johannes, Beerli, Christian, Billich, Andreas, Dawson, Janet, Kaupmann, Klemens, Streiff, Markus, Gobeau, Nathalie, Harlfinger, Stephanie, Stringer, Rowan, Guntermann, Christine

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Stereoselective gold-catalyzed cycloaddition of functionalized ketoenynes: synthesis of (+)-orientalol F von Jiménez-Núñez, Eloísa, Molawi, Kian, Echavarren, Antonio M

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Molecular diversity through gold catalysis with alkynes von Jiménez-Núñez, Eloísa, Echavarren, Antonio M

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Evolution of Propargyl Ethers into Allylgold Cations in the Cyclization of Enynes von Jiménez-Núñez, Eloísa, Raducan, Mihai, Lauterbach, Thorsten, Molawi, Kian, Solorio, César R, Echavarren, Antonio M

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Gold(I)-Catalyzed Cyclizations of 1,6-Enynes: Alkoxycyclizations and exo/endo Skeletal Rearrangements von Nieto-Oberhuber, Cristina, Muñoz, M. Paz, López, Salomé, Jiménez-Núñez, Eloísa, Nevado, Cristina, Herrero-Gómez, Elena, Raducan, Mihai, Echavarren, Antonio M.

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ChemInform Abstract: Complexity via Gold-Catalyzed Molecular Gymnastics von Echavarren, Antonio M., Jimenez-Nunez, Eloisa

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On the Mechanism of the Puzzling "Endocyclic" Skeletal Rearrangement of 1,6-Enynes von Cabello, Noemí, Jiménez-Núñez, Eloísa, Buñuel, Elena, Cárdenas, Diego J., Echavarren, Antonio M.

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ChemInform Abstract: Gold-Catalyzed Cycloisomerizations of Enynes: A Mechanistic Perspective von Jimenez-Nunez, Eloisa, Echavarren, Antonio M.

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Gold(I)-Catalyzed Intramolecular Cyclopropanation of Dienynes von Nieto-Oberhuber, Cristina, López, Salomé, Muñoz, M. Paz, Jiménez-Núñez, Eloísa, Buñuel, Elena, Cárdenas, Diego J., Echavarren, Antonio M.

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ChemInform Abstract: Stereoselective Gold-Catalyzed Cycloaddition of Functionalized Ketoenynes: Synthesis of (+)-Orientalol F von Jimenez-Nunez, Eloisa, Molawi, Kian, Echavarren, Antonio M.

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Design and Preclinical Characterization Program toward Asundexian (BAY 2433334), an Oral Factor XIa Inhibitor for the Prevention and Treatment of Thromboembolic Disorders von Roehrig, Susanne, Ackerstaff, Jens, Jiménez Núñez, Eloísa, Teller, Henrik, Ellerbrock, Pascal, Meier, Katharina, Heitmeier, Stefan, Tersteegen, Adrian, Stampfuss, Jan, Lang, Dieter, Schlemmer, Karl-Heinz, Schaefer, Martina, Gericke, Kersten M., Kinzel, Tom, Meibom, Daniel, Schmidt, Martina, Gerdes, Christoph, Follmann, Markus, Hillisch, Alexander

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