Twenty years on: the impact of fragments on drug discovery von Erlanson, Daniel A., Fesik, Stephen W., Hubbard, Roderick E., Jahnke, Wolfgang, Jhoti, Harren

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The 'rule of three' for fragment-based drug discovery: where are we now? von Jhoti, Harren, Williams, Glyn, Rees, David C., Murray, Christopher W.

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Detection of secondary binding sites in proteins using fragment screening von Ludlow, R. Frederick, Verdonk, Marcel L., Saini, Harpreet K., Tickle, Ian J., Jhoti, Harren

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A ‘Rule of Three’ for fragment-based lead discovery? von Congreve, Miles, Carr, Robin, Murray, Chris, Jhoti, Harren

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Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design von O’Reilly, Marc, Cleasby, Anne, Davies, Thomas G., Hall, Richard J., Ludlow, R. Frederick, Murray, Christopher W., Tisi, Dominic, Jhoti, Harren

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High-throughput crystallography for lead discovery in drug design von Blundell, Tom L., Jhoti, Harren, Abell, Chris

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Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone von Williams, Pamela A., Cosme, Jose, Vinković, Dijana Matak, Ward, Alison, Angove, Hayley C., Day, Philip J., Vonrhein, Clemens, Tickle, Ian J., Jhoti, Harren

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Crystal structure of human CDK4 in complex with a D-type cyclin von Day, Philip J, Cleasby, Anne, Tickle, Ian J, O'Reilly, Marc, Coyle, Joe E, Holding, Finn P, McMenamin, Rachel L, Yon, Jeff, Chopra, Rajiv, Lengauer, Christoph, Jhoti, Harren

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Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B von van Montfort, Rob L. M., Congreve, Miles, Tisi, Dominic, Carr, Robin, Jhoti, Harren

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Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function von Saalau-Bethell, Susanne M, Woodhead, Andrew J, Chessari, Gianni, Carr, Maria G, Coyle, Joseph, Graham, Brent, Hiscock, Steven D, Murray, Christopher W, Pathuri, Puja, Rich, Sharna J, Richardson, Caroline J, Williams, Pamela A, Jhoti, Harren

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Structure-based screening of low-affinity compounds von Carr, Robin, Jhoti, Harren

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Application of Fragment Screening and Fragment Linking to the Discovery of Novel Thrombin Inhibitors von Howard, Nigel, Abell, Chris, Blakemore, Wendy, Chessari, Gianni, Congreve, Miles, Howard, Steven, Jhoti, Harren, Murray, Christopher W, Seavers, Lisa C. A, van Montfort, Rob L. M

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A new school for screening von Jhoti, Harren

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A Structural Comparison of Inhibitor Binding to PKB, PKA and PKA-PKB Chimera von Davies, Thomas G., Verdonk, Marcel L., Graham, Brent, Saalau-Bethell, Susanne, Hamlett, Christopher C.F., McHardy, Tatiana, Collins, Ian, Garrett, Michelle D., Workman, Paul, Woodhead, Steven J., Jhoti, Harren, Barford, David

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Fragments: where are we now? von Osborne, James, Panova, Stanislava, Rapti, Magdalini, Urushima, Tatsuya, Jhoti, Harren

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Structure-Based Drug Discovery von Jhoti, Harren, Leach, Andrew R

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High-throughput protein crystallography and drug discovery von Tickle, Ian, Sharff, Andrew, Vinkovic, Mladen, Yon, Jeff, Jhoti, Harren

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Fragment-based drug discovery using cryo-EM von Saur, Michael, Hartshorn, Michael J., Dong, Jing, Reeks, Judith, Bunkoczi, Gabor, Jhoti, Harren, Williams, Pamela A.

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Fragment-based screening using X-ray crystallography and NMR spectroscopy von Jhoti, Harren, Cleasby, Anne, Verdonk, Marcel, Williams, Glyn

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Crystal structure of human cytochrome P450 2C9 with bound warfarin von Williams, Pamela A., Cosme, Jose, Ward, Alison, Angove, Hayley C., Matak Vinković, Dijana, Jhoti, Harren

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