Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate von Andexer, Jennifer N, Kendrew, Steven G, Nur-e-Alam, Mohammad, Lazos, Orestis, Foster, Teresa A, Zimmermann, Anna-Sophie, Warneck, Tony D, Suthar, Dipen, Coates, Nigel J, Koehn, Frank E, Skotnicki, Jerauld S, Carter, Guy T, Gregory, Matthew A, Martin, Christine J, Moss, Steven J, Leadlay, Peter F, Wilkinson, Barrie

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Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway von CRABTREE, Judy S, JELINSKY, Scott A, DAVE, Bhuvanesh, BROADDUS, Russell R, BROWN, Eugene L, WENLING KAO, SKOTNICKI, Jerauld S, ABOU-GHARBIA, Magid, WINNEKER, Richard C, WALKER, Cheryl L, HARRIS, Heather A, CHOE, Sung E, COTREAU, Monette M, KIMBERLAND, Michelle L, WILSON, Ewa, SARAF, Kathryn A, WEI LIU, MCCAMPBELL, Adrienne S

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Synthesis of rapamycin glycoconjugates via a CuAAC-based approach von Moni, Lisa, Marra, Alberto, Skotnicki, Jerauld S., Koehn, Frank E., Abou-Gharbia, Magid, Dondoni, Alessandro

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Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis von Hu, Yonghan, Xiang, Jason S., DiGrandi, Martin J., Du, Xuemei, Ipek, Manus, Laakso, Leif M., Li, Jianchang, Li, Wei, Rush, Thomas S., Schmid, Jean, Skotnicki, Jerauld S., Tam, Steve, Thomason, Jennifer R., Wang, Qin, Levin, Jeremy I.

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Recombinant strains for the enhanced production of bioengineered rapalogs von Kendrew, Steven G., Petkovic, Hrvoje, Gaisser, Sabine, Ready, Sarah J., Gregory, Matthew A., Coates, Nigel J., Nur-e-Alam, Mohammad, Warneck, Tony, Suthar, Dipen, Foster, Teresa A., McDonald, Leonard, Schlingman, Gerhard, Koehn, Frank E., Skotnicki, Jerauld S., Carter, Guy T., Moss, Steven J., Zhang, Ming-Qiang, Martin, Christine J., Sheridan, Rose M., Wilkinson, Barrie

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Synthesis and SAR of highly selective MMP-13 inhibitors von Li, Jianchang, Rush, Thomas S., Li, Wei, DeVincentis, Dianne, Du, Xuemei, Hu, Yonghan, Thomason, Jennifer R., Xiang, Jason S., Skotnicki, Jerauld S., Tam, Steve, Cunningham, Kristina M., Chockalingam, Priya S., Morris, Elisabeth A., Levin, Jeremy I.

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3,4-Disubstituted benzofuran P1′ MMP-13 inhibitors: Optimization of selectivity and reduction of protein binding von Li, Wei, Hu, Yonghan, Li, Jianchang, Thomason, Jennifer R., DeVincentis, Dianne, Du, Xuemei, Wu, Junjun, Hotchandani, Rajeev, Rush, Thomas S., Skotnicki, Jerauld S., Tam, Steve, Chockalingam, Priya S., Morris, Elisabeth A., Levin, Jeremy I.

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Synthesis and Structure−Activity Relationship of N-Substituted 4-Arylsulfonylpiperidine-4-hydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treat... von Aranapakam, Venkatesan, Davis, Jamie M, Grosu, George T, Baker, Ellingboe, John, Zask, Arie, Levin, Jeremy I, Sandanayaka, Vincent P, Du, Mila, Skotnicki, Jerauld S, DiJoseph, John F, Sung, Amy, Sharr, Michele A, Killar, Loran M, Walter, Thomas, Jin, Guixian, Cowling, Rebecca, Tillett, Jeff, Zhao, Weiguang, McDevitt, Joseph, Xu, Zhang Bao

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Synthesis and Structure−Activity Relationship of α-Sulfonylhydroxamic Acids as Novel, Orally Active Matrix Metalloproteinase Inhibitors for the Treatment of Osteoarthritis von Aranapakam, Venkatesan, Grosu, George T, Davis, Jamie M, Hu, Baihua, Ellingboe, John, Baker, Jannie L, Skotnicki, Jerauld S, Zask, Arie, DiJoseph, John F, Sung, Amy, Sharr, Michele A, Killar, Loran M, Walter, Thomas, Jin, Guixian, Cowling, Rebecca

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Synthesis and Structure−Activity Relationships of 4-alkynyloxy Phenyl Sulfanyl, Sulfinyl, and Sulfonyl Alkyl Hydroxamates as Tumor Necrosis Factor-α Converting Enzyme and Matrix Me... von Venkatesan, Aranapakam M, Davis, Jamie M, Grosu, George T, Baker, Jannie, Zask, Arie, Levin, Jeremy I, Ellingboe, John, Skotnicki, Jerauld S, DiJoseph, John F, Sung, Amy, Jin, Guixian, Xu, Weixin, McCarthy, Diane Joseph, Barone, Dauphine

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2-phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis von ZHONG LI, FRANCISCO, Gerardo D, SKOTNICKI, Jerauld S, MANSOUR, Tarek S, HU, William, LABTHAVIKUL, Pornpen, PETERSEN, Peter J, SEVERIN, Anatoly, SINGH, Guy, YOUJUN YANG, RASMUSSEN, Beth A, LIN, Yang-I

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Urolithiasis associated with the protease inhibitor indinavir von Bruce, R. Grady, Munch, Larry C., Hoven, Ardis D., Jerauld, Richard S., Greenburg, Richard, Porter, William H., Rutter, Philip W.

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NMR Solution Structure of the Catalytic Fragment of Human Fibroblast Collagenase Complexed with a Sulfonamide Derivative of a Hydroxamic Acid Compound von Moy, Franklin J, Chanda, Pranab K, Chen, James M, Cosmi, Scott, Edris, Wade, Skotnicki, Jerauld S, Wilhelm, Jim, Powers, Robert

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Benzodiazepine inhibitors of the MMPs and TACE von NELSON, Frances C, DELOS SANTOS, Efren, GUIXIAN JIN, ROTH, Catherine E, ALBRIGHT, J. Donald, LEVIN, Jeremy I, CHEN, James M, SKOTNICKI, Jerauld S, DIJOSEPH, John F, SHARR, Michele A, SUNG, Amy, KILLAR, Loran M, COWLING, Rebecca

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Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases von LEVIN, Jeremy I, YANSONG GU, COSMI, Scott, HSIAO, Chu-Lai, EDRIS, Wade, WILHELM, James, KILLAR, Loran M, SKOTNICKI, Jerauld S, NELSON, Frances C, ZASK, Arie, DIJOSEPH, John F, SHARR, Michele A, SUNG, Amy, GUIXIAN JIN, COWLING, Rebecca, CHANDA, Pranab

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The synthesis and biological activity of a novel series of diazepine MMP inhibitors von Levin, Jeremy I., DiJoseph, John F., Killar, Loran M., Sung, Amy, Walter, Thomas, Sharr, Michele A., Roth, Catherine E., Skotnicki, Jerauld S., Albright, J.Donald

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Patent Update: Anti-inflammatory Patent Highlights from the Second Half of 1992 von Kreft, Anthony F, Schiehser, Guy A, Skotnicki, Jerauld S

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Design and Synthetic Considerations of Matrix Metalloproteinase Inhibitors von SKOTNICKI, JERAULD S., ZASK, ARIE, NELSON, FRANCES C., ALBRIGHT, J. DONALD, LEVIN, JEREMY I.

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Heterocyclization with cyano and sulfonyl epoxides. Preparation of quinoxalines and tetrahydroquinoxalines von Taylor, Edward C, Maryanoff, Cynthia A, Skotnicki, Jerauld S

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The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position von LEVIN, Jeremy I, DU, Mila T, GUIXIAN JIN, COWLING, Rebecca, SKOTNICKI, Jerauld S, DIJOSEPH, John F, KILLAR, Loran M, SUNG, Amy, WALTER, Thomas, SHARR, Michele A, ROTH, Catherine E, MOY, Franklin J, POWERS, Robert

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