A computational approach to distinguish somatic vs. germline origin of genomic alterations from deep sequencing of cancer specimens without a matched normal von Sun, James X, He, Yuting, Sanford, Eric, Montesion, Meagan, Frampton, Garrett M, Vignot, Stéphane, Soria, Jean-Charles, Ross, Jeffrey S, Miller, Vincent A, Stephens, Phil J, Lipson, Doron, Yelensky, Roman

Volltext

Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study von Sicklick, Jason K., Kato, Shumei, Okamura, Ryosuke, Schwaederle, Maria, Hahn, Michael E., Williams, Casey B., De, Pradip, Krie, Amy, Piccioni, David E., Miller, Vincent A., Ross, Jeffrey S., Benson, Adam, Webster, Jennifer, Stephens, Philip J., Lee, J. Jack, Fanta, Paul T., Lippman, Scott M., Leyland-Jones, Brian, Kurzrock, Razelle

Volltext

Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients von Serebriiskii, Ilya G., Connelly, Caitlin, Frampton, Garrett, Newberg, Justin, Cooke, Matthew, Miller, Vince, Ali, Siraj, Ross, Jeffrey S., Handorf, Elizabeth, Arora, Sanjeevani, Lieu, Christopher, Golemis, Erica A., Meyer, Joshua E.

Volltext

Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers von Pozdeyev, Nikita, Gay, Laurie M, Sokol, Ethan S, Hartmaier, Ryan, Deaver, Kelsi E, Davis, Stephanie, French, Jena D, Borre, Pierre Vanden, LaBarbera, Daniel V, Tan, Aik-Choon, Schweppe, Rebecca E, Fishbein, Lauren, Ross, Jeffrey S, Haugen, Bryan R, Bowles, Daniel W

Volltext

Whole Cancer Genome Sequencing by Next-Generation Methods von ROSS, Jeffrey S, CRONIN, Maureen

Volltext

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden von Chalmers, Zachary R, Connelly, Caitlin F, Fabrizio, David, Gay, Laurie, Ali, Siraj M, Ennis, Riley, Schrock, Alexa, Campbell, Brittany, Shlien, Adam, Chmielecki, Juliann, Huang, Franklin, He, Yuting, Sun, James, Tabori, Uri, Kennedy, Mark, Lieber, Daniel S, Roels, Steven, White, Jared, Otto, Geoffrey A, Ross, Jeffrey S, Garraway, Levi, Miller, Vincent A, Stephens, Phillip J, Frampton, Garrett M

Volltext

Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer von Mehnert, Janice M, Panda, Anshuman, Zhong, Hua, Hirshfield, Kim, Damare, Sherri, Lane, Katherine, Sokol, Levi, Stein, Mark N, Rodriguez-Rodriquez, Lorna, Kaufman, Howard L, Ali, Siraj, Ross, Jeffrey S, Pavlick, Dean C, Bhanot, Gyan, White, Eileen P, DiPaola, Robert S, Lovell, Ann, Cheng, Jonathan, Ganesan, Shridar

Volltext

A Novel Next-Generation Sequencing Approach to Detecting Microsatellite Instability and Pan-Tumor Characterization of 1000 Microsatellite Instability–High Cases in 67,000 Patient S... von Trabucco, Sally E., Gowen, Kyle, Maund, Sophia L., Sanford, Eric, Fabrizio, David A., Hall, Michael J., Yakirevich, Evgeny, Gregg, Jeffrey P., Stephens, Phil J., Frampton, Garrett M., Hegde, Priti S., Miller, Vincent A., Ross, Jeffrey S., Hartmaier, Ryan J., Huang, Shih-Min A., Sun, James X.

Volltext

The distribution of BRAF gene fusions in solid tumors and response to targeted therapy von Ross, Jeffrey S., Wang, Kai, Chmielecki, Juliann, Gay, Laurie, Johnson, Adrienne, Chudnovsky, Jacob, Yelensky, Roman, Lipson, Doron, Ali, Siraj M, Elvin, Julia A., Vergilio, Jo‐Anne, Roels, Steven, Miller, Vincent A, Nakamura, Brooke N., Gray, Adam, Wong, Michael K, Stephens, Philip J

Volltext

Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3 von Ross, Jeffrey S., Fakih, Marwan, Ali, Siraj M., Elvin, Julia A., Schrock, Alexa B., Suh, James, Vergilio, Jo‐Anne, Ramkissoon, Shakti, Severson, Eric, Daniel, Sugganth, Fabrizio, David, Frampton, Garrett, Sun, James, Miller, Vincent A., Stephens, Philip J., Gay, Laurie M.

Volltext

Impact of EML4-ALK Variant on Resistance Mechanisms and Clinical Outcomes in ALK-Positive Lung Cancer von Lin, Jessica J, Zhu, Viola W, Yoda, Satoshi, Yeap, Beow Y, Schrock, Alexa B, Dagogo-Jack, Ibiayi, Jessop, Nicholas A, Jiang, Ginger Y, Le, Long P, Gowen, Kyle, Stephens, Philip J, Ross, Jeffrey S, Ali, Siraj M, Miller, Vincent A, Johnson, Melissa L, Lovly, Christine M, Hata, Aaron N, Gainor, Justin F, Iafrate, Anthony J, Shaw, Alice T, Ou, Sai-Hong Ignatius

Volltext

Impact of Molecular Subtyping and Immune Infiltration on Pathological Response and Outcome Following Neoadjuvant Pembrolizumab in Muscle-invasive Bladder Cancer von Necchi, Andrea, Raggi, Daniele, Gallina, Andrea, Ross, Jeffrey S., Farè, Elena, Giannatempo, Patrizia, Marandino, Laura, Colecchia, Maurizio, Lucianò, Roberta, Bianchi, Marco, Colombo, Renzo, Salonia, Andrea, Gandaglia, Giorgio, Fossati, Nicola, Bandini, Marco, Pederzoli, Filippo, Capitanio, Umberto, Montorsi, Francesco, de Jong, Joep J., Dittamore, Ryan, Liu, Yang, Davicioni, Elai, Boormans, Joost L., Briganti, Alberto, Black, Peter C., Gibb, Ewan A.

Volltext

Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions von Lovly, Christine M, Gupta, Abha, Lipson, Doron, Otto, Geoff, Brennan, Tina, Chung, Catherine T, Borinstein, Scott C, Ross, Jeffrey S, Stephens, Philip J, Miller, Vincent A, Coffin, Cheryl M

Volltext

ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer von Pietrantonio, Filippo, Di Nicolantonio, Federica, Schrock, Alexa B, Lee, Jeeyun, Tejpar, Sabine, Sartore-Bianchi, Andrea, Hechtman, Jaclyn F, Christiansen, Jason, Novara, Luca, Tebbutt, Niall, Fucà, Giovanni, Antoniotti, Carlotta, Kim, Seung Tae, Murphy, Danielle, Berenato, Rosa, Morano, Federica, Sun, James, Min, Bosun, Stephens, Philip J, Chen, Marissa, Lazzari, Luca, Miller, Vincent A, Shoemaker, Robert, Amatu, Alessio, Milione, Massimo, Ross, Jeffrey S, Siena, Salvatore, Bardelli, Alberto, Ali, Siraj M, Falcone, Alfredo, de Braud, Filippo, Cremolini, Chiara

Volltext

A pan-cancer analysis of PD-L1 immunohistochemistry and gene amplification, tumor mutation burden and microsatellite instability in 48,782 cases von Huang, Richard S.P., Haberberger, James, Severson, Eric, Duncan, Daniel L., Hemmerich, Amanda, Edgerly, Claire, Ferguson, Naomi Lynn, Williams, Erik, Elvin, Julia, Vergilio, Jo-Anne, Killian, Jonathan Keith, Lin, Douglas I., Tse, Julie, Hiemenz, Matthew, Owens, Clarence, Danziger, Natalie, Hegde, Priti S., Venstrom, Jeffrey, Alexander, Brian, Ross, Jeffrey S., Ramkissoon, Shakti H.

Volltext

Clinicopathologic Characteristics of BRG1-Deficient NSCLC von Dagogo-Jack, Ibiayi, Schrock, Alexa B., Kem, Marina, Jessop, Nicholas, Lee, Jessica, Ali, Siraj M., Ross, Jeffrey S., Lennerz, Jochen K., Shaw, Alice T., Mino-Kenudson, Mari

Volltext

Diverse EGFR Exon 20 Insertions and Co-Occurring Molecular Alterations Identified by Comprehensive Genomic Profiling of NSCLC von Riess, Jonathan W., Gandara, David R., Frampton, Garrett M., Madison, Russell, Peled, Nir, Bufill, Jose A., Dy, Grace K., Ou, Sai-Hong Ignatius, Stephens, Philip J., McPherson, John D., Lara, Primo N., Burich, Rebekah A., Ross, Jeffrey S., Miller, Vincent A., Ali, Siraj M., Mack, Philip C., Schrock, Alexa B.

Volltext

The HER‐2 Receptor and Breast Cancer: Ten Years of Targeted Anti–HER‐2 Therapy and Personalized Medicine von Ross, Jeffrey S., Slodkowska, Elzbieta A., Symmans, W. Fraser, Pusztai, Lajos, Ravdin, Peter M., Hortobagyi, Gabriel N.

Volltext

Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer von Panda, Anshuman, Mehnert, Janice M, Hirshfield, Kim M, Riedlinger, Greg, Damare, Sherri, Saunders, Tracie, Kane, Michael, Sokol, Levi, Stein, Mark N, Poplin, Elizabeth, Rodriguez-Rodriguez, Lorna, Silk, Ann W, Aisner, Joseph, Chan, Nancy, Malhotra, Jyoti, Frankel, Melissa, Kaufman, Howard L, Ali, Siraj, Ross, Jeffrey S, White, Eileen P, Bhanot, Gyan, Ganesan, Shridar

Volltext

Receptor Tyrosine Kinase Fusions and BRAF Kinase Fusions are Rare but Actionable Resistance Mechanisms to EGFR Tyrosine Kinase Inhibitors von Schrock, Alexa B., Zhu, Viola W., Hsieh, Wen-Son, Madison, Russell, Creelan, Benjamin, Silberberg, Jeffrey, Costin, Dan, Bharne, Anjali, Bonta, Ioana, Bosemani, Thangavijayan, Nikolinakos, Petros, Ross, Jeffrey S., Miller, Vincent A., Ali, Siraj M., Klempner, Samuel J., Ou, Sai-Hong Ignatius

Volltext