Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective von Johnstone, Shawn, Albert, Jeffrey S.

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Efficient synthesis of a 7-azabicyclo[2.2.1]heptane based GlyT1 uptake inhibitor von Xiong, Hui, Frietze, William, Andisik, Donald W., Ernst, Glen E., Palmer, William E., Hinkley, Lindsay, Varnes, Jeffrey G., Albert, Jeffrey S., Veale, Chris A.

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Asymmetric Synthesis of a Potent CXCR7 Modulator Featuring a Hindered Tertiary β‑Amino Amide Stereocenter von Canterbury, Daniel P, Godin, Francois, Desjardins, Samuel, Bayrakdarian, Malken, Albert, Jeffrey S, Perry, David A, Hesp, Kevin D

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Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency... von Edwards, Philip D, Albert, Jeffrey S, Sylvester, Mark, Aharony, David, Andisik, Donald, Callaghan, Owen, Campbell, James B, Carr, Robin A, Chessari, Gianni, Congreve, Miles, Frederickson, Martyn, Folmer, Rutger H. A, Geschwindner, Stefan, Koether, Gerard, Kolmodin, Karin, Krumrine, Jennifer, Mauger, Russell C, Murray, Christopher W, Olsson, Lise-Lotte, Patel, Sahil, Spear, Nate, Tian, Gaochao

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Discovery of a Novel Warhead against β-Secretase through Fragment-Based Lead Generation von Geschwindner, Stefan, Olsson, Lise-Lotte, Albert, Jeffrey S, Deinum, Johanna, Edwards, Philip D, de Beer, Tonny, Folmer, Rutger H. A

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Development of a Plate-Based Optical Biosensor Fragment Screening Methodology to Identify Phosphodiesterase 10A Inhibitors von Geschwindner, Stefan, Dekker, Niek, Horsefield, Rob, Tigerström, Anna, Johansson, Patrik, Scott, Clay W, Albert, Jeffrey S

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Design, Synthesis, and SAR of Tachykinin Antagonists:  Modulation of Balance in NK1/NK2 Receptor Antagonist Activity von Albert, Jeffrey S, Aharony, David, Andisik, Donald, Barthlow, Herbert, Bernstein, Peter R, Bialecki, Russell A, Dedinas, Robert, Dembofsky, Bruce T, Hill, Daniel, Kirkland, Karin, Koether, Gerard M, Kosmider, Benedict J, Ohnmacht, Cyrus, Palmer, William, Potts, William, Rumsey, William, Shen, Lihong, Shenvi, Ashok, Sherwood, Scott, Warwick, Paul J, Russell, Keith

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Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1 von Varnes, Jeffrey G., Xiong, Hui, Forst, Janet M., Holmquist, Christopher R., Ernst, Glen E., Frietze, William, Dembofsky, Bruce, Andisik, Don W., Palmer, William E., Hinkley, Lindsay, Steelman, Gary B., Wilkins, Deidre E., Tian, Gaochao, Jonak, Gerald, Potts, William M., Wang, Xia, Brugel, Todd A., Alhambra, Cristóbal, Wood, Michael W., Veale, Chris A., Albert, Jeffrey S.

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Discovery of a series of aryl-N-(3-(alkylamino)-5-(trifluoromethyl)phenyl)benzamides as TRPA1 antagonists von Laliberté, Sébastien, Vallée, Frédéric, Fournier, Pierre-André, Bedard, Leanne, Labrecque, Jean, Albert, Jeffrey S.

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Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors von Varnes, Jeffrey G., Geschwindner, Stefan, Holmquist, Christopher R., Forst, Janet, Wang, Xia, Dekker, Niek, Scott, Clay W., Tian, Gaochao, Wood, Michael W., Albert, Jeffrey S.

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Structural Analysis and Optimization of NK1 Receptor Antagonists through Modulation of Atropisomer Interconversion Properties von Albert, Jeffrey S, Ohnmacht, Cyrus, Bernstein, Peter R, Rumsey, William L, Aharony, David, Alelyunas, Yun, Russell, Daniel J, Potts, William, Sherwood, Scott A, Shen, Lihong, Dedinas, Robert F, Palmer, William E, Russell, Keith

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Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists von Hu, Yun-Jin, St.-Onge, Miguel, Laliberté, Sébastien, Vallée, Frédéric, Jin, Shujuan, Bedard, Leanne, Labrecque, Jean, Albert, Jeffrey S.

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Discovery of a Novel Muscarinic Receptor PET Radioligand with Rapid Kinetics in the Monkey Brain von Malmquist, Jonas, Varnäs, Katarina, Svedberg, Marie, Vallée, Frédéric, Albert, Jeffrey S, Finnema, Sjoerd J, Schou, Magnus

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Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists von OHNMACHT, Cyrus J, ALBERT, Jeffrey S, BERNSTEIN, Peter R, RUMSEY, William L, MASEK, Brian B, DEMBOFSKY, Bruce T, KOETHER, Gerard M, ANDISIK, Donald W, AHARONY, David

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Stabilization of Helical Domains in Short Peptides Using Hydrophobic Interactions von Albert, Jeffrey S, Hamilton, Andrew D

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Molecular Recognition of Proteins: Sequence-Selective Binding of Aspartate Pairs in Helical Peptides von Albert, Jeffrey S, Goodman, M. Scott, Hamilton, Andrew D

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Discovery of novel, orally active dual NK1/NK2 antagonists von BERNSTEIN, Peter R, AHARONY, David, KOSMIDER, Benedict J, KIRKLAND, Karin, OHNMACHT, Cyrus J, POTTS, William, RUMSEY, William L, LIHONG SHEN, SHENVI, Ashok, SHERWOOD, Scott, STOLLMAN, David, RUSSELL, Keith, ALBERT, Jeffrey S, ANDISIK, Donald, BARTHLOW, Herbert G, BIALECKI, Russell, DAVENPORT, Timothy, DEDINAS, Robert F, DEMBOFSKY, Bruce T, KOETHER, Gerard

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Synthesis and SAR of sulfoxide substituted carboxyquinolines as NK3 receptor antagonists von Xiong, Hui, Kang, James, Woods, James M., McCauley, John P., Koether, Gerard M., Albert, Jeffrey S., Hinkley, Lindsay, Li, Yan, Gadient, Reto A., Simpson, Thomas R.

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Neurokinin antagonists and their potential role in treating depression and other stress disorders von Albert, Jeffrey S

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Roles of TRPA1 in Pain Pathophysiology and Implications for the Development of a New Class of Analgesic Drugs von Radresa, Olivier, Dahllöf, Henrik, Nyman, Eva, Nolting, Andreas, Albert, Jeffrey S., Raboisson, Patrick

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