Therapeutic Effects of FGF23 c‐tail Fc in a Murine Preclinical Model of X‐Linked Hypophosphatemia Via the Selective Modulation of Phosphate Reabsorption von Johnson, Kristen, Levine, Kymberly, Sergi, Joseph, Chamoun, Jean, Roach, Rachel, Vekich, Jacqueline, Favis, Mike, Horn, Mark, Cao, Xianjun, Miller, Brian, Snyder, William, Aivazian, Dikran, Reagan, William, Berryman, Edwin, Colangelo, Jennifer, Markiewicz, Victoria, Bagi, Cedo M, Brown, Thomas P, Coyle, Anthony, Mohammadi, Moosa, Magram, Jeanne

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Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present von Cooper, Andrea M, Kipnis, Andre, Turner, Joanne, Magram, Jeanne, Ferrante, Jessica, Orme, Ian M

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THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses von Gately, Maurice K, Renzetti, Louis M, Magram, Jeanne, Stern, Alvin S, Adorini, Luciano, Gubler, Ueli, Presky, David H

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Interleukin-12 Is Essential for a Protective Th1 Response in Mice Infected with Cryptococcus neoformans von Decken, K, Köhler, G, Palmer-Lehmann, K, Wunderlin, A, Mattner, F, Magram, J, Gately, M K, Alber, G

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IL-12 Receptor β2 (IL-12Rβ2)-Deficient Mice Are Defective in IL-12-Mediated Signaling Despite the Presence of High Affinity IL-12 Binding Sites von Wu, Chang-you, Wang, Xin, Gadina, Massimo, O’Shea, John J., Presky, David H., Magram, Jeanne

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Characterization of Glucokinase Regulatory Protein-deficient Mice von Grimsby, Joseph, Coffey, John W., Dvorozniak, Mark T., Magram, Jeanne, Li, Guizhu, Matschinsky, Franz M., Shiota, Chiyo, Kaur, Satbir, Magnuson, Mark A., Grippo, Joseph F.

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Reduced incidence and severity of collagen‐induced arthritis in interleukin‐12‐deficient mice von McIntyre, Kim W., Shuster, David J., Gillooly, Kathleen M., Warrier, Rajeev R., Connaughton, Suzanne E., Hall, Leroy B., Arp, Lawrence H., Gately, Maurice K., Magram, Jeanne

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SINGLE CELL RNA SEQUENCING OF ULCERATIVE COLITIS AND CROHN'S DISEASE TISSUE SAMPLES INFORMS THE SELECTION OF TREM1 AS A TARGET FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES von Grant, Sarah, Johnson, Kristen, Thomas, Tom, Honig, Gerard, Bielecki, Piotr, Dendrou, Calliope, Guo, Sean, Kulicke, Ruth, Li, Ping, L’Italien, Larry, Spies, Noah, Stransky, Nicolas, Uhlig, Holm, Varma, Mukund, Travis, Simon, Buckley, Christopher, Magram, Jeanne

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Vascular endothelial cell lineage-specific promoter in transgenic mice von Schlaeger, T M, Qin, Y, Fujiwara, Y, Magram, J, Sato, T N

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Pancreas-Infiltrating Th1 Cells and Diabetes Develop in IL-12-Deficient Nonobese Diabetic Mice von Trembleau, Sylvie, Penna, Giuseppe, Gregori, Silvia, Chapman, Harold D, Serreze, David V, Magram, Jeanne, Adorini, Luciano

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SINGLE CELL RNA SEQUENCING OF ULCERATIVE COLITIS AND CROHN'S DISEASE TISSUE SAMPLES INFORMS THE SELECTION OF TREM1 AS A TARGET FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES von Grant, Sarah, Johnson, Kristen, Thomas, Tom, Honig, Gerard, Bielecki, Piotr, Dendrou, Calliope, Guo, Sean, Kulicke, Ruth, Li, Ping, L'Italien, Larry, Spies, Noah, Stransky, Nicolas, Uhlig, Holm, Varma, Mukund, Travis, Simon, Buckley, Christopher, Magram, Jeanne

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Impaired Th2 Subset Development in the Absence of CD4 von Fowell, Deborah J, Magram, Jeanne, Turck, Christoph W, Killeen, Nigel, Locksley, Richard M

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Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies von Raman, Swetha, Beilschmidt, Melissa, To, Minh, Lin, Kevin, Lui, Francine, Jmeian, Yazen, Ng, Mark, Fernandez, Minerva, Fu, Ying, Mascall, Keith, Duque, Alejandro, Wang, Xiaowei, Pan, Guohua, Angers, Stephane, Moffat, Jason, Sidhu, Sachdev S., Magram, Jeanne, Sinclair, Angus M., Fransson, Johan, Julien, Jean-Philippe

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IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes von Brombacher, Frank, Dorfmüller, Andreas, Magram, Jeanne, Dai, Wen Juan, Köhler, Gabriele, Wunderlin, Andrea, Palmer-Lehmann, Kathrin, Gately, Maurice K., Alber, Gottfried

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Meetings of the minds: maximizing drug discovery von Magram, Jeanne

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Abstract LB-B34: LIF as a novel cancer immunotherapy target: modulating the tumor microenvironment with MSC-1, a humanized anti-LIF monoclonal antibody von Magram, Jeanne, Pandya, Naimish, Hoffman, Kimberly, Hallett, Robin, Giblin, Patricia, Sinclair, Angus, Anido, Judit, Ruano, Isabel Huber, Sala, Ada, Pascual, Monica, Chiganças, Vanessa, Wasserman, Robert, Seoane, Joan

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Abstract 1751: MSC-1 is a first-in-class humanized monoclonal antibody that modulates the tumor microenvironment by inhibiting a novel cancer immunotherapy target, LIF von Sinclair, Angus, Hallett, Robin, Giblin, Patricia, Huber-Ruano, Isabel, Anido, Judit, Pandya, Naimish, Hoffman, Kimberly, Sala, Ada, Pascual, Monica, Chigancas, Vanessa, Raman, Swetha, Fransson, Johan, Julien, Jean-Philippe, Wasserman, Robert, Magram, Jeanne, Seoane, Joan

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A phase 1 study of MSC-1, a humanized anti-LIF monoclonal antibody, in patients with advanced solid tumors von Hyman, David Michael, Brana, Irene, Spreafico, Anna, Schram, Alison M., Pandya, Naimish B., Hoffman, Kimberly, Hallet, Robin, Giblin, Patricia, Anido, Judit, Ruano, Isabel Huber, Wasserman, Robert, Magram, Jeanne, Siu, Lillian L., Tabernero, Josep, Seoane, Joan, Baselga, Jose

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Interleukin 12 (IL-12) is crucial to the development of protective immunity in mice intravenously infected with mycobacterium tuberculosis von Cooper, A M, Magram, J, Ferrante, J, Orme, I M

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Therapeutic Effects of FGF23 c-tail Fc in a murine pre-clinical model of X-linked hypophosphatemia via the selective modulation of phosphate reabsorption von Johnson, Kristen, Levine, Kymberly, Sergi, Joseph, Chamoun, Jean, Roach, Rachel, Vekich, Jackie, Favis, Mike, Horn, Mark, Cao, Xianjun, Miller, Brian, Snyder, William, Aivazian, Dikran, Reagan, William, Berryman, Edwin, Colangelo, Jennifer, Markiewicz, Victoria, Bagi, Cedo, Brown, Thomas P., Coyle, Anthony, Mohammadi, Moosa, Magram, Jeanne

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