The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties von Goepfert, Arnaud, Lehmann, Sylvie, Wirth, Emmanuelle, Rondeau, Jean-Michel

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The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease von Neumann, Ulf, Ufer, Mike, Jacobson, Laura H, Rouzade‐Dominguez, Marie‐Laure, Huledal, Gunilla, Kolly, Carine, Lüönd, Rainer M, Machauer, Rainer, Veenstra, Siem J, Hurth, Konstanze, Rueeger, Heinrich, Tintelnot‐Blomley, Marina, Staufenbiel, Matthias, Shimshek, Derya R, Perrot, Ludovic, Frieauff, Wilfried, Dubost, Valerie, Schiller, Hilmar, Vogg, Barbara, Beltz, Karen, Avrameas, Alexandre, Kretz, Sandrine, Pezous, Nicole, Rondeau, Jean‐Michel, Beckmann, Nicolau, Hartmann, Andreas, Vormfelde, Stefan, David, Olivier J, Galli, Bruno, Ramos, Rita, Graf, Ana, Lopez Lopez, Cristina

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Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β von Hommel, Ulrich, Hurth, Konstanze, Rondeau, Jean-Michel, Vulpetti, Anna, Ostermeier, Daniela, Boettcher, Andreas, Brady, Jacob Peter, Hediger, Michael, Lehmann, Sylvie, Koch, Elke, Blechschmidt, Anke, Yamamoto, Rina, Tundo Dottorello, Valentina, Haenni-Holzinger, Sandra, Kaiser, Christian, Lehr, Philipp, Lingel, Andreas, Mureddu, Luca, Schleberger, Christian, Blank, Jutta, Ramage, Paul, Freuler, Felix, Eder, Joerg, Bornancin, Frédéric

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Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria von Nishimura, Jun-Ichi, Ando, Kiyoshi, Masuko, Masayoshi, Noji, Hideyoshi, Ito, Yoshikazu, Mayer, Jiri, Griskevicius, Laimonas, Bucher, Christoph, Müllershausen, Florian, Gergely, Peter, Rozenberg, Izabela, Schubart, Anna, Chawla, Raghav, Rondeau, Jean-Michel, Roguska, Michael, Splawski, Igor, Keating, Mark T, Johnson, Leslie, Danekula, Rambabu, Bagger, Morten, Watanabe, Yoko, Haraldsson, Börje, Kanakura, Yuzuru

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A General Strategy for Targeting Drugs to Bone von Jahnke, Wolfgang, Bold, Guido, Marzinzik, Andreas L., Ofner, Silvio, Pellé, Xavier, Cotesta, Simona, Bourgier, Emmanuelle, Lehmann, Sylvie, Henry, Chrystelle, Hemmig, René, Stauffer, Frédéric, Hartwieg, J. Constanze D., Green, Jonathan R., Rondeau, Jean-Michel

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Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling von Goepfert, Arnaud, Lehmann, Sylvie, Blank, Jutta, Kolbinger, Frank, Rondeau, Jean-Michel

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Protein crystallization in stirred systems-scale-up via the maximum local energy dissipation von Smejkal, Benjamin, Helk, Bernhard, Rondeau, Jean-Michel, Anton, Sabine, Wilke, Angelika, Scheyerer, Peter, Fries, Jacqueline, Hekmat, Dariusch, Weuster-Botz, Dirk

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Structural Basis for the Exceptional in vivo Efficacy of Bisphosphonate Drugs von Rondeau, Jean-Michel, Bitsch, Francis, Bourgier, Emmanuelle, Geiser, Martin, Hemmig, Rene, Kroemer, Markus, Lehmann, Sylvie, Ramage, Paul, Rieffel, Sebastien, Strauss, André, Green, Jonathan R., Jahnke, Wolfgang

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Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery von Jahnke, Wolfgang, Rondeau, Jean-Michel, Cotesta, Simona, Marzinzik, Andreas, Pellé, Xavier, Geiser, Martin, Strauss, André, Götte, Marjo, Bitsch, Francis, Hemmig, René, Henry, Chrystèle, Lehmann, Sylvie, Glickman, J Fraser, Roddy, Thomas P, Stout, Steven J, Green, Jonathan R

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Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors von Rueeger, Heinrich, Rondeau, Jean-Michel, McCarthy, Clive, Möbitz, Henrik, Tintelnot-Blomley, Marina, Neumann, Ulf, Desrayaud, Sandrine

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Redirecting an anti-IL-1β antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A von Fischman, Sharon, Levin, Itay, Rondeau, Jean-Michel, Štrajbl, Marek, Lehmann, Sylvie, Huber, Thomas, Nimrod, Guy, Cebe, Régis, Omer, Dotan, Kovarik, Jiri, Bernstein, Shmuel, Sasson, Yehezkel, Demishtein, Alik, Shlamkovich, Tomer, Bluvshtein, Olga, Grossman, Noam, Barak-Fuchs, Reut, Zhenin, Michael, Fastman, Yair, Twito, Shir, Vana, Tal, Zur, Nevet, Ofran, Yanay

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Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy von Morvan, Frederic, Rondeau, Jean-Michel, Zou, Chao, Minetti, Giulia, Scheufler, Clemens, Scharenberg, Meike, Jacobi, Carsten, Brebbia, Pascale, Ritter, Veronique, Toussaint, Gauthier, Koelbing, Claudia, Leber, Xavier, Schilb, Alain, Witte, Florian, Lehmann, Sylvie, Koch, Elke, Geisse, Sabine, Glass, David J., Lach-Trifilieff, Estelle

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Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding von Marzinzik, Andreas L., Amstutz, René, Bold, Guido, Bourgier, Emmanuelle, Cotesta, Simona, Glickman, J. Fraser, Götte, Marjo, Henry, Christelle, Lehmann, Sylvie, Hartwieg, J. Constanze D., Ofner, Silvio, Pellé, Xavier, Roddy, Thomas P., Rondeau, Jean-Michel, Stauffer, Frédéric, Stout, Steven J., Widmer, Armin, Zimmermann, Johann, Zoller, Thomas, Jahnke, Wolfgang

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Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease von Machauer, Rainer, Lueoend, Rainer, Hurth, Konstanze, Veenstra, Siem J, Rueeger, Heinrich, Voegtle, Markus, Tintelnot-Blomley, Marina, Rondeau, Jean-Michel, Jacobson, Laura H, Laue, Grit, Beltz, Karen, Neumann, Ulf

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SEC-TID: A Label-Free Method for Small-Molecule Target Identification von Salcius, Michael, Bauer, Andras J., Hao, Qin, Li, Shu, Tutter, Antonin, Raphael, Jacob, Jahnke, Wolfgang, Rondeau, Jean-Michel, Bourgier, Emmanuelle, Tallarico, John, Michaud, Gregory A.

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Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Pe... von Rueeger, Heinrich, Lueoend, Rainer, Rogel, Olivier, Rondeau, Jean-Michel, Möbitz, Henrik, Machauer, Rainer, Jacobson, Laura, Staufenbiel, Matthias, Desrayaud, Sandrine, Neumann, Ulf

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Secukinumab for the treatment of psoriasis, psoriatic arthritis, and axial spondyloarthritis: Physical and pharmacological properties underlie the observed clinical efficacy and sa... von Kolbinger, Frank, Di Padova, Franco, Deodhar, Atul, Hawkes, Jason E., Huppertz, Christine, Kuiper, Torsten, McInnes, Iain B., Ritchlin, Christopher T., Rosmarin, David, Schett, Georg, Carballido, José M., Häusermann, Peter, Calonder, Claudio, Vogel, Beate, Rondeau, Jean-Michel, Bruin, Gerard

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Synthesis of the Potent, Selective, and Efficacious β‑Secretase (BACE1) Inhibitor NB-360 von Rueeger, Heinrich, Lueoend, Rainer, Machauer, Rainer, Veenstra, Siem J, Holzer, Philipp, Hurth, Konstanze, Voegtle, Markus, Frederiksen, Mathias, Rondeau, Jean-Michel, Tintelnot-Blomley, Marina, Jacobson, Laura H, Staufenbiel, Matthias, Laue, Grit, Neumann, Ulf

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The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β von Rondeau, Jean-Michel, Ramage, Paul, Zurini, Mauro, Gram, Hermann

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IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling von Goepfert, Arnaud, Barske, Carmen, Lehmann, Sylvie, Wirth, Emmanuelle, Willemsen, Joschka, Gudjonsson, Johann E., Ward, Nicole L., Sarkar, Mrinal K., Hemmig, René, Kolbinger, Frank, Rondeau, Jean-Michel

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