Cardiac spheroids as promising in vitro models to study the human heart microenvironment von Polonchuk, Liudmila, Chabria, Mamta, Badi, Laura, Hoflack, Jean-Christophe, Figtree, Gemma, Davies, Michael J., Gentile, Carmine

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Use of toxicogenomics in drug safety evaluation: Current status and an industry perspective von Vahle, John L., Anderson, Ulf, Blomme, Eric A.G., Hoflack, Jean-Christophe, Stiehl, Daniel P.

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Primary Endothelial Damage Is the Mechanism of Cardiotoxicity of Tubulin-Binding Drugs von Mikaelian, Igor, Buness, Andreas, de Vera-Mudry, Maria-Cristina, Kanwal, Charu, Coluccio, Denise, Rasmussen, Erik, Char, Hing W., Carvajal, Valerie, Hilton, Holly, Funk, Juergen, Hoflack, Jean-Christophe, Fielden, Mark, Herting, Frank, Dunn, Michael, Suter-Dick, Laura

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A novel orally available small molecule that inhibits hepatitis B virus expression von Mueller, Henrik, Wildum, Steffen, Luangsay, Souphalone, Walther, Johanna, Lopez, Anaïs, Tropberger, Philipp, Ottaviani, Giorgio, Lu, Wenzhe, Parrott, Neil John, Zhang, Jitao David, Schmucki, Roland, Racek, Tomas, Hoflack, Jean-Christophe, Kueng, Erich, Point, Floriane, Zhou, Xue, Steiner, Guido, Lütgehetmann, Marc, Rapp, Gianna, Volz, Tassilo, Dandri, Maura, Yang, Song, Young, John A.T., Javanbakht, Hassan

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Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor torcetrapib involve L-type calcium channels von Clerc, Roger G, Stauffer, Andrea, Weibel, Franziska, Hainaut, Emmanuelle, Perez, Anne, Hoflack, Jean-Christophe, Bénardeau, Agnès, Pflieger, Philippe, Garriz, Jose MR, Funder, John W, Capponi, Alessandro M, Niesor, Eric J

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Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms von Ellinger-Ziegelbauer, Heidrun, Fostel, Jennifer M., Aruga, Chinami, Bauer, Daniel, Boitier, Eric, Deng, Shibing, Dickinson, Donna, Le Fevre, Anne-Celine, Fornace, Albert J., Grenet, Olivier, Gu, Yizhong, Hoflack, Jean-Christophe, Shiiyama, Masako, Smith, Roger, Snyder, Ronald D., Spire, Catherine, Tanaka, Gotaro, Aubrecht, Jiri

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HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model von Melo, Esther, Oertle, Philipp, Trepp, Carolyn, Meistermann, Hélène, Burgoyne, Thomas, Sborgi, Lorenzo, Cabrera, Alvaro Cortes, Chen, Chia-yi, Hoflack, Jean-Christophe, Kam-Thong, Tony, Schmucki, Roland, Badi, Laura, Flint, Nicholas, Ghiani, Zeynep Eren, Delobel, Fréderic, Stucki, Corinne, Gromo, Giulia, Einhaus, Alfred, Hornsperger, Benoit, Golling, Sabrina, Siebourg-Polster, Juliane, Gerber, Francoise, Bohrmann, Bernd, Futter, Clare, Dunkley, Tom, Hiller, Sebastian, Schilling, Oliver, Enzmann, Volker, Fauser, Sascha, Plodinec, Marija, Iacone, Roberto

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Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells von Drawnel, Faye M., Boccardo, Stefano, Prummer, Michael, Delobel, Frédéric, Graff, Alexandra, Weber, Michael, Gérard, Régine, Badi, Laura, Kam-Thong, Tony, Bu, Lei, Jiang, Xin, Hoflack, Jean-Christophe, Kiialainen, Anna, Jeworutzki, Elena, Aoyama, Natsuyo, Carlson, Coby, Burcin, Mark, Gromo, Gianni, Boehringer, Markus, Stahlberg, Henning, Hall, Benjamin J., Magnone, Maria Chiara, Kolaja, Kyle, Chien, Kenneth R., Bailly, Jacques, Iacone, Roberto

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Drug-induced Obstructive and Retrograde Nephropathy Associated with α2u-globulin in Male Rats von Jacobsen, Björn, Freichel, Christian, Eichinger-Chapelon, Anne, Brink, Andreas, Hoflack, Jean-Christophe, Albassam, Mudher, Lenz, Barbara

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Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator von Nudischer, Ramona, Renggli, Kasper, Bertinetti-Lapatki, Cristina, Hoflack, Jean-Christophe, Flint, Nicholas, Sewing, Sabine, Pedersen, Lykke, Schadt, Simone, Higgins, Larry G, Vardy, Audrey, Lenz, Barbara, Gand, Laurent, Boess, Franziska, Elcombe, Barbara M, Hierlemann, Andreas, Roth, Adrian B

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Epithelial cells as active player in fibrosis: findings from an in vitro model von Moll, Solange, Ebeling, Martin, Weibel, Franziska, Farina, Annarita, Araujo Del Rosario, Andrea, Hoflack, Jean Christophe, Pomposiello, Silvia, Prunotto, Marco

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A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection von Bosch, Miriam, Kallin, Nina, Donakonda, Sainitin, Zhang, Jitao David, Wintersteller, Hannah, Hegenbarth, Silke, Heim, Kathrin, Ramirez, Carlos, Fürst, Anna, Lattouf, Elias Isaac, Feuerherd, Martin, Chattopadhyay, Sutirtha, Kumpesa, Nadine, Griesser, Vera, Hoflack, Jean-Christophe, Siebourg-Polster, Juliane, Mogler, Carolin, Swadling, Leo, Pallett, Laura J., Meiser, Philippa, Manske, Katrin, de Almeida, Gustavo P., Kosinska, Anna D., Sandu, Ioana, Schneider, Annika, Steinbacher, Vincent, Teng, Yan, Schnabel, Julia, Theis, Fabian, Gehring, Adam J., Boonstra, Andre, Janssen, Harry L. A., Vandenbosch, Michiel, Cuypers, Eva, Öllinger, Rupert, Engleitner, Thomas, Rad, Roland, Steiger, Katja, Oxenius, Annette, Lo, Wan-Lin, Klepsch, Victoria, Baier, Gottfried, Holzmann, Bernhard, Maini, Mala K., Heeren, Ron, Murray, Peter J., Thimme, Robert, Herrmann, Carl, Protzer, Ulrike, Böttcher, Jan P., Zehn, Dietmar, Wohlleber, Dirk, Lauer, Georg M., Hofmann, Maike, Luangsay, Souphalone, Knolle, Percy A.

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Cardiac spheroid co-cultures as a novel in vitro model to study human heart microenvironment von Polonchuk, Liudmila, Chabria, Mamta, Badi, Laura, Hoflack, Jean-Christophe, Davies, Michael J., Figtree, Gemma, Gentile, Carmine

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Carnitine Palmitoyltransferase 2 (CPT2) Inhibition in Rats And Dogs Resembles Inborn Human CPT2 Deficiency von DE VERA MUDRY, MARIA CRISTINA, FESTAG, MATTHIAS, HOFLACK, JEAN‐CHRISTOPHE, CRAMERI, FLAVIO

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Characterization of anti-peptide antibodies directed towards the automodification domain and apoptotic fragment of poly(ADP-ribose) polymerase von Duriez, Patrick J, Desnoyers, Serge, Hoflack, Jean-Christophe, Shah, Girish M, Morelle, Bruno, Bourassa, Sylvie, Poirier, Guy G, Talbot, Brian

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Tailoring in silico model to electrophysiology of individual iPSC-derived cardiomyocyte lines: One-size fits all? von Lei, Chon Lok, Wang, Ken, Gissinger, Evgenia, Flint, Nicholas, Mamta, Chabria, Badi, Laura, Hoflack, Jean-Christophe, Schuler, Franz, Lave, Thierry, Singer, Thomas, Clerx, Michael, Gavaghan, David, Mirams, Gary, Polonchuk, Liudmila

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How much of a cardiomyocyte can we get from stem cells? Setting up metrics for cardiac cell models von Chabria, Mamta, Hoflack, Jean-Christophe, Badi, Laura, Flint, Nicholas, Burcin, Mark, Graf, Martin, Singer, Thomas, Alvarez-Sanchez, Ruben, Schuler, Franz, Polonchuk, Liudmila

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The role of poly(ADP-ribose) metabolism in response to active oxygen cytotoxicity von Lautier, Dominique, Hoflack, Jean-Christophe, Kirkland, James B, Poirier, Danièle, Poirier, Guy G

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Methods for Biochemical Study of Poly(ADP-Ribose) Metabolism in Vitro and in Vivo von Shah, G.M., Poirier, D., Duchaine, C., Brochu, G., Desnoyers, S., Lagueux, J., Verreault, A., Hoflack, J.C., Kirkland, J.B., Poirier, G.G.

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OLIGONUCLEOTIDES FOR MODULATING RTEL1 EXPRESSION von KAM-THONG, Tony, LEONARD, Brian, BERRERA, Marco, WALLIER, Angelina, KAMMLER, Susanne, FELBER, Josephine, TROPBERGER, Philipp, HOFLACK, Jean-Christophe, TRIYATNI, Miriam, TURLEY, Daniel Jeremy, PEDERSEN, Lykke, ZHANG, Jitao David

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