CRLX101, a Nanoparticle-Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1α von Tian, Xi, Nguyen, Minh, Foote, Henry P, Caster, Joseph M, Roche, Kyle C, Peters, Christian G, Wu, Pauline, Jayaraman, Lata, Garmey, Edward G, Tepper, Joel E, Eliasof, Scott, Wang, Andrew Z

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Abstract 2839: Leveraging gut microbiota networks to impact tumor immunotherapy von Jayaraman, Lata, Sceneay, Jaclyn

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Physical and Functional Interaction of SMADs and p300/CBP von Pouponnot, Celio, Jayaraman, Lata, Massagué, Joan

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Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1) von Purandare, Ashok V., Chen, Zhong, Huynh, Tram, Pang, Suhong, Geng, Jieping, Vaccaro, Wayne, Poss, Michael A., Oconnell, Jonathan, Nowak, Kimberly, Jayaraman, Lata

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Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1) von Huynh, Tram, Chen, Zhong, Pang, Suhong, Geng, Jieping, Bandiera, Tiziano, Bindi, Simona, Vianello, Paola, Roletto, Fulvia, Thieffine, Sandrine, Galvani, Arturo, Vaccaro, Wayne, Poss, Michael A., Trainor, George L., Lorenzi, Matthew V., Gottardis, Marco, Jayaraman, Lata, Purandare, Ashok V.

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An electrophoretic mobility shift assay for the identification and kinetic analysis of acetyl transferase inhibitors von Fanslau, Caroline, Pedicord, Donna, Nagulapalli, Sujatha, Gray, Hillary, Pang, Suhong, Jayaraman, Lata, Lippy, Jonathan, Blat, Yuval

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Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer von Huang, Audris, Jayaraman, Lata, Fura, Aberra, Vite, Gregory D, Trainor, George L, Gottardis, Marco M, Spires, Thomas E, Spires, Vanessa M, Rizzo, Cheryl A, Obermeier, Mary T, Elzinga, Paul A, Todderud, Gordon, Fan, Yi, Newitt, John A, Beyer, Sophie M, Zhu, Yongxin, Warrack, Bethanne M, Goodenough, Angela K, Tebben, Andrew J, Doweyko, Arthur M, Gold, David L, Balog, Aaron

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Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus von Jayaraman, Lata, Prives, Carol

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Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors von Morris, Erick J, Jha, Sharda, Restaino, Clifford R, Dayananth, Priya, Zhu, Hugh, Cooper, Alan, Carr, Donna, Deng, Yongi, Jin, Weihong, Black, Stuart, Long, Brian, Liu, Jenny, Dinunzio, Edward, Windsor, William, Zhang, Rumin, Zhao, Shuxia, Angagaw, Minilik H, Pinheiro, Elaine M, Desai, Jagdish, Xiao, Li, Shipps, Gerald, Hruza, Alan, Wang, James, Kelly, Joe, Paliwal, Sunil, Gao, Xiaolei, Babu, Boga Sobhana, Zhu, Liang, Daublain, Pierre, Zhang, Ling, Lutterbach, Bart A, Pelletier, Marc R, Philippar, Ulrike, Siliphaivanh, Phieng, Witter, David, Kirschmeier, Paul, Bishop, W Robert, Hicklin, Daniel, Gilliland, D Gary, Jayaraman, Lata, Zawel, Leigh, Fawell, Stephen, Samatar, Ahmed A

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Abstract 3209: CRLX101, an investigational nanoparticle-drug conjugate of camptothecin, demonstrates synergy with immunotherapy agents in preclinical models von Lazarus, Douglas, Peters, Christian, Stockmann, Adam, Eliasof, Scott, Jayaraman, Lata

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Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle-Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer von Pham, Elizabeth, Yin, Melissa, Peters, Christian G, Lee, Christina R, Brown, Donna, Xu, Ping, Man, Shan, Jayaraman, Lata, Rohde, Ellen, Chow, Annabelle, Lazarus, Douglas, Eliasof, Scott, Foster, F Stuart, Kerbel, Robert S

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The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer von Padmakar Darne, Chetan, Velaparthi, Upender, Saulnier, Mark, Frennesson, David, Liu, Peiying, Huang, Audris, Tokarski, John, Fura, Aberra, Spires, Thomas, Newitt, John, Spires, Vanessa M., Obermeier, Mary T., Elzinga, Paul A., Gottardis, Marco M., Jayaraman, Lata, Vite, Gregory D., Balog, Aaron

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A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit von Kopinja, Johnny, Sevilla, Raquel S., Levitan, Diane, Dai, David, Vanko, Amy, Spooner, Edward, Ware, Chris, Forget, Robert, Hu, Kun, Kral, Astrid, Spacciapoli, Peter, Kennan, Richard, Jayaraman, Lata, Pucci, Vincenzo, Perera, Samanthi, Zhang, Weisheng, Fischer, Christian, Lam, Michael H.

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Abstract LB-283: Leveraging gut microbiota networks to impact tumor immunotherapy von Sceneay, Jaclyn, Srinivasan, Srimathi, Halley, Keith, Marnellos, George, Wortman, Jennifer, Henn, Matthew, Fink, Elura, Litcofsky, Kevin, Cook, David, Jayaraman, Lata

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Dissecting Therapeutic Resistance to ERK Inhibition von Jha, Sharda, Morris, Erick J, Hruza, Alan, Mansueto, My Sam, Schroeder, Gottfried K, Arbanas, Jaren, McMasters, Daniel, Restaino, Clifford R, Dayananth, Priya, Black, Stuart, Elsen, Nathaniel L, Mannarino, Anthony, Cooper, Alan, Fawell, Stephen, Zawel, Leigh, Jayaraman, Lata, Samatar, Ahmed A

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Abstract CT090: Phase II trial of the NDC CRLX101 in combination with bevacizumab in patients with platinum-resistant ovarian cancer (PROC) von Krasner, Carolyn, Birrer, Michael, Peters, Christian, Jayaraman, Lata, Eliasof, Scott, Tellez, Andres, Downing, William, Senderowicz, Adrian

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Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1 von Markwalder, Jay A., Balog, Aaron J., Williams, David K., Nara, Susheel J., Reddy, Ratnakar, Roy, Saumya, Kanyaboina, Yadagiri, Li, Xin, Johnston, Kathy, Fan, Yi, Lewis, Hal, Marsilio, Frank, Yan, Chunhong, Critton, David, Newitt, John A., Traeger, Sarah C., Wu, Dauh-Rurng, Jure-Kunkel, Maria N., Jayaraman, Lata, Lin, Tai-An, Sinz, Michael W., Hunt, John T., Seitz, Steven P.

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Stool donor qualification and collection from metastatic melanoma (MM) patients (pts) who have responded to checkpoint inhibitors (CPI) for manufacturing of fecal microbiota transp... von Burton, Elizabeth M., Glitza, Isabella Claudia, Mahoney, Jennifer, Wortman, Jennifer, Aunis, John, Litcofsky, Kevin, Cook, David, Jayaraman, Lata, Ibrahim, Ramy A., LaVallee, Theresa, Tawbi, Hussein Abdul-Hassan, Wargo, Jennifer A.

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Abstract 1345: Tumor selective localization of CRLX101, an investigational nanoparticle-drug conjugate of camptothecin von Peters, Christian G., Lazarus, Douglas, Brown, Donna, Zhang, Ningning, Stockmann, Adam P., Case, Roy, Rohde, Ellen, Eliasof, Scott, Jayaraman, Lata

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Structural basis for CARM1 inhibition by indole and pyrazole inhibitors von Sack, John S, Thieffine, Sandrine, Bandiera, Tiziano, Fasolini, Marina, Duke, Gerald J, Jayaraman, Lata, Kish, Kevin F, Klei, Herbert E, Purandare, Ashok V, Rosettani, Pamela, Troiani, Sonia, Xie, Dianlin, Bertrand, Jay A

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