Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H von Kankanala, Jayakanth, Kirby, Karen A, Liu, Feng, Miller, Lena, Nagy, Eva, Wilson, Daniel J, Parniak, Michael A, Sarafianos, Stefan G, Wang, Zhengqiang

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Toward Structurally Novel and Metabolically Stable HIV-1 Capsid-Targeting Small Molecules von Vernekar, Sanjeev Kumar V., Sahani, Rajkumar Lalji, Casey, Mary C., Kankanala, Jayakanth, Wang, Lei, Kirby, Karen A., Du, Haijuan, Zhang, Huanchun, Tedbury, Philip R., Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang

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Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza von Scott, Claire, Kankanala, Jayakanth, Foster, Toshana L., Goldhill, Daniel H., Bao, Peng, Simmons, Katie, Pingen, Marieke, Bentham, Matthew, Atkins, Elizabeth, Loundras, Eleni, Eldertield, Ruth, Claridge, Jolyon K., Thompson, Joseph, Stilwell, Peter R., Tathineni, Ranjitha, McKimmie, Clive S., Targett-Adams, Paul, Schnell, Jason R., Cook, Graham P., Evans, Stephen, Barclay, Wendy S., Foster, Richard, Griffin, Stephen

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Discovery of N-benzyl hydroxypyridone carboxamides as a novel and potent antiviral chemotype against human cytomegalovirus (HCMV) von Senaweera, Sameera, Edwards, Tiffany C., Kankanala, Jayakanth, Wang, Yan, Sahani, Rajkumar Lalji, Xie, Jiashu, Geraghty, Robert J., Wang, Zhengqiang

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Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy von Shaw, Joseph, Gosain, Rajendra, Kalita, Monoj Mon, Foster, Toshana L., Kankanala, Jayakanth, Mahato, D. Ram, Abas, Sonia, King, Barnabas J., Scott, Claire, Brown, Emma, Bentham, Matthew J., Wetherill, Laura, Bloy, Abigail, Samson, Adel, Harris, Mark, Mankouri, Jamel, Rowlands, David J., Macdonald, Andrew, Tarr, Alexander W., Fischer, Wolfgang B., Foster, Richard, Griffin, Stephen

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In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis von Latham, Antony M, Kankanala, Jayakanth, Fearnley, Gareth W, Gage, Matthew C, Kearney, Mark T, Homer-Vanniasinkam, Shervanthi, Wheatcroft, Stephen B, Fishwick, Colin W G, Ponnambalam, Sreenivasan

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Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2) von Kankanala, Jayakanth, Marchand, Christophe, Abdelmalak, Monica, Aihara, Hideki, Pommier, Yves, Wang, Zhengqiang

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Receptor tyrosine kinase structure and function in health and disease von A. Karpov, Oleg, W. Fearnley, Gareth, A. Smith, Gina, Kankanala, Jayakanth, J. McPherson, Michael, C. Tomlinson, Darren, A. Harrison, Michael, Ponnambalam, Sreenivasan

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Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors von Kiselev, Evgeny, Ravji, Azhar, Kankanala, Jayakanth, Xie, Jiashu, Wang, Zhengqiang, Pommier, Yves

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5′-Silylated 3′-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue Virus von Vernekar, Sanjeev Kumar V, Qiu, Li, Zhang, Jing, Kankanala, Jayakanth, Li, Hongmin, Geraghty, Robert J, Wang, Zhengqiang

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Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage von Wang, Yan, Mao, Lili, Kankanala, Jayakanth, Wang, Zhengqiang, Geraghty, Robert J

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Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2‑Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transc... von Vernekar, Sanjeev Kumar V, Liu, Zheng, Nagy, Eva, Miller, Lena, Kirby, Karen A, Wilson, Daniel J, Kankanala, Jayakanth, Sarafianos, Stefan G, Parniak, Michael A, Wang, Zhengqiang

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Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease von Kankanala, Jayakanth, Wang, Yan, Geraghty, Robert J., Wang, Zhengqiang

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Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors von Ribeiro, Carlos J.A., Kankanala, Jayakanth, Xie, Jiashu, Williams, Jessica, Aihara, Hideki, Wang, Zhengqiang

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Bimetallic (Cu/Pd) catalytic cascade reactions to 3,3-disubstituted oxindole analogues von Packer, Gemma, Lepre, Kurt, Kankanala, Jayakanth, Sridharan, Visuvanathar

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Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H von Kankanala, Jayakanth, Kirby, Karen A., Huber, Andrew D., Casey, Mary C., Wilson, Daniel J., Sarafianos, Stefan G., Wang, Zhengqiang

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3‑Hydroxypyrimidine-2,4-dione-5‑N‑benzylcarboxamides Potently Inhibit HIV‑1 Integrase and RNase H von Wu, Bulan, Tang, Jing, Wilson, Daniel J, Huber, Andrew D, Casey, Mary C, Ji, Juan, Kankanala, Jayakanth, Xie, Jiashu, Sarafianos, Stefan G, Wang, Zhengqiang

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Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etop... von Kankanala, Jayakanth, Ribeiro, Carlos J. A, Kiselev, Evgeny, Ravji, Azhar, Williams, Jessica, Xie, Jiashu, Aihara, Hideki, Pommier, Yves, Wang, Zhengqiang

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5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors von Tang, Jing, Huber, Andrew D., Pineda, Dallas L., Boschert, Kelsey N., Wolf, Jennifer J., Kankanala, Jayakanth, Xie, Jiashu, Sarafianos, Stefan G., Wang, Zhengqiang

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Repurposing N-hydroxy thienopyrimidine-2,4-diones (HtPD) as inhibitors of human cytomegalovirus pUL89 endonuclease: Synthesis and biological characterization von He, Tianyu, Edwards, Tiffany C., Majima, Ryuichi, Jung, Eunkyung, Kankanala, Jayakanth, Xie, Jiashu, Geraghty, Robert J., Wang, Zhengqiang

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