C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN von HONG XIAO, DAIRAGHI, Daniel J, BAO LU, GERARD, Norma P, GERARD, Craig, SCHALL, Thomas J, JAEN, Juan C, FALK, Ronald J, JENNETTE, J. Charles, POWERS, Jay P, ERTL, Linda S, BAUMGART, Trageen, YU WANG, SEITZ, Lisa C, PENFOLD, Mark E. T, LIN GAN, PEIQI HU

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Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers von Seitz, Lisa, Jin, Lixia, Leleti, Manmohan, Ashok, Devika, Jeffrey, Jenna, Rieger, Aimee, Tiessen, Renger G., Arold, Gerhard, Tan, Joanne B. L., Powers, Jay P., Walters, Matthew J., Karakunnel, Joyson

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CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease von Dairaghi, Daniel J., Oyajobi, Babatunde O., Gupta, Anjana, McCluskey, Brandon, Miao, Shichang, Powers, Jay P., Seitz, Lisa C., Wang, Yu, Zeng, Yibin, Zhang, Penglie, Schall, Thomas J., Jaen, Juan C.

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Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ectonucleotidases CD73 and CD39 von Jeffrey, Jenna L, Lawson, Kenneth V, Powers, Jay P

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Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes von Sullivan, Timothy J, Miao, Zhenhua, Zhao, Bin N, Ertl, Linda S, Wang, Yu, Krasinski, Antoni, Walters, Matthew J, Powers, Jay P, Dairaghi, Daniel J, Baumgart, Trageen, Seitz, Lisa C, Berahovich, Robert D, Schall, Thomas J, Jaen, Juan C

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Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4 von Powers, Jay P., Li, Shyun, Jaen, Juan C., Liu, Jinqian, Walker, Nigel P.C., Wang, Zhulun, Wesche, Holger

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CCR9 Antagonists in the Treatment of Ulcerative Colitis von Sullivan, Timothy J., Jaen, Juan C., Schall, Thomas J., Powers, Jay P., Punna, Sreenivas, Charvat, Trevor T., Ertl, Linda S., Berahovich, Robert D., Walters, Matthew J., Ebsworth, Karen, Bekker, Pirow, Campbell, James J.

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Discovery of AB680: A Potent and Selective Inhibitor of CD73 von Lawson, Kenneth V, Kalisiak, Jaroslaw, Lindsey, Erick A, Newcomb, Eric T, Leleti, Manmohan Reddy, Debien, Laurent, Rosen, Brandon R, Miles, Dillon H, Sharif, Ehesan U, Jeffrey, Jenna L, Tan, Joanne B. L, Chen, Ada, Zhao, Sharon, Xu, Guifen, Fu, Lijuan, Jin, Lixia, Park, Tim W, Berry, Wade, Moschütz, Susanne, Scaletti, Emma, Sträter, Norbert, Walker, Nigel P, Young, Stephen W, Walters, Matthew J, Schindler, Uli, Powers, Jay P

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Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73 von Beatty, Joel W, Lindsey, Erick A, Thomas-Tran, Rhiannon, Debien, Laurent, Mandal, Debashis, Jeffrey, Jenna L, Tran, Anh T, Fournier, Jeremy, Jacob, Steven D, Yan, Xuelei, Drew, Samuel L, Ginn, Elaine, Chen, Ada, Pham, Amber T, Zhao, Sharon, Jin, Lixia, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Moschütz, Susanne, Sträter, Norbert, Powers, Jay P, Lawson, Kenneth V

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Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors von Sharif, Ehesan U., Kalisiak, Jaroslaw, Lawson, Kenneth, Miles, Dillon H., Newcomb, Eric, Lindsey, Erick A., Rosen, Brandon R., Debien, Laurent P. P., Chen, Ada, Zhao, Xiaoning, Young, Stephen W., Walker, Nigel P., Straeter, Norbert, Scaletti, Emma R., Jin, Lixia, Xu, Guifen, Leleti, Manmohan R., Powers, Jay P.

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Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity von Piovesan, Dana, Tan, Joanne B L, Becker, Annette, Banuelos, Jesus, Narasappa, Nell, DiRenzo, Daniel, Zhang, Kristen, Chen, Ada, Ginn, Elaine, Udyavar, Akshata R, Yin, Fangfang, Paprcka, Susan L, Purandare, Bhamini, Park, Timothy W, Kimura, Nikki, Kalisiak, Jaroslaw, Young, Stephen W, Powers, Jay P, Schindler, Uli, Sivick, Kelsey E, Walters, Matthew J

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Discovery of Potent and Selective PI3Kγ Inhibitors von Drew, Samuel L, Thomas-Tran, Rhiannon, Beatty, Joel W, Fournier, Jeremy, Lawson, Kenneth V, Miles, Dillon H, Mata, Guillaume, Sharif, Ehesan U, Yan, Xuelei, Mailyan, Artur K, Ginn, Elaine, Chen, Jie, Wong, Kent, Soni, Divyank, Dhanota, Puja, Chen, Pei-Yu, Shaqfeh, Stefan G, Meleza, Cesar, Pham, Amber T, Chen, Ada, Zhao, Xiaoning, Banuelos, Jesus, Jin, Lixia, Schindler, Ulrike, Walters, Matthew J, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L

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Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase γ (PI3Kγ) von Mata, Guillaume, Miles, Dillon H, Drew, Samuel L, Fournier, Jeremy, Lawson, Kenneth V, Mailyan, Artur K, Sharif, Ehesan U, Yan, Xuelei, Beatty, Joel W, Banuelos, Jesus, Chen, Jie, Ginn, Elaine, Chen, Ada, Gerrick, Kimberline Y, Pham, Amber T, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G, Meleza, Cesar, Narasappa, Nell, Singh, Hema, Zhao, Xiaoning, Jin, Lixia, Schindler, Ulrike, Walters, Matthew J, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L

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Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors von Gonzalez-Lopez de Turiso, Felix, Sun, Daqing, Rew, Yosup, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Correll, Tiffany L, Huang, Xin, Julian, Lisa D, Kayser, Frank, Lo, Mei-Chu, Long, Alexander M, McMinn, Dustin, Oliner, Jonathan D, Osgood, Tao, Powers, Jay P, Saiki, Anne Y, Schneider, Steve, Shaffer, Paul, Xiao, Shou-Hua, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H

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Crystal Structures of IRAK-4 Kinase in Complex with Inhibitors: A Serine/Threonine Kinase with Tyrosine as a Gatekeeper von Wang, Zhulun, Liu, Jinsong, Sudom, Athena, Ayres, Merrill, Li, Shyun, Wesche, Holger, Powers, Jay P., Walker, Nigel P.C.

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Discovery of Potent and Selective 7‑Azaindole Isoindolinone-Based PI3Kγ Inhibitors von Miles, Dillon H, Yan, Xuelei, Thomas-Tran, Rhiannon, Fournier, Jeremy, Sharif, Ehesan U, Drew, Samuel L, Mata, Guillaume, Lawson, Kenneth V, Ginn, Elaine, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G, Meleza, Cesar, Chen, Ada, Pham, Amber T, Park, Timothy, Swinarski, Debbie, Banuelos, Jesus, Schindler, Ulrike, Walters, Matthew J, Walker, Nigel P, Zhao, Xiaoning, Young, Stephen W, Chen, Jie, Jin, Lixia, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L

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SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase von Powers, Jay P, Piper, Derek E, Li, Yang, Mayorga, Veronica, Anzola, John, Chen, James M, Jaen, Juan C, Lee, Gary, Liu, Jinqian, Peterson, M. Greg, Tonn, George R, Ye, Qiuping, Walker, Nigel P. C, Wang, Zhulun

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Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4 von Wang, Zhulun, Sun, Daqing, Johnstone, Sheree, Cao, Zhaodan, Gao, Xiong, Jaen, Juan C., Liu, Jingqian, Lively, Sarah, Miao, Shichang, Sudom, Athena, Tomooka, Craig, Walker, Nigel P.C., Wright, Matthew, Yan, Xuelei, Ye, Qiuping, Powers, Jay P.

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ITOC2 – 011. Identification of second-generation potent and selective inhibitors of indoleamine-2,3-dioxygenase-1 (IDO1) for the treatment of cancer von Juan, Jaen C, Pia, Bjorck, Jordan, Fridman S, Lisa, Marshall, Jan, Melom, Rajkumar, Noubade, Max, Osipov, Matthew, Walters J, Mikhail, Zibinsky, Jay, Powers P

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Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors von Rew, Yosup, DeGraffenreid, Michael, He, Xiao, Jaen, Juan C., McMinn, Dustin L., Sun, Daqing, Tu, Hua, Ursu, Stefania, Powers, Jay P.

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