Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity von Rook, Jerri M, Noetzel, Meredith J, Pouliot, Wendy A, Bridges, Thomas M, Vinson, Paige N, Cho, Hyekyung P, Zhou, Ya, Gogliotti, Rocco D, Manka, Jason T, Gregory, Karen J, Stauffer, Shaun R, Dudek, F. Edward, Xiang, Zixiu, Niswender, Colleen M, Daniels, J. Scott, Jones, Carrie K, Lindsley, Craig W, Conn, P. Jeffrey

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Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety von Felts, Andrew S., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Manka, Jason T., Bates, Brittney S., Blobaum, Anna L., Byers, Frank W., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.

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Synthesis and SAR of centrally active mGlu₅ positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold von Williams, Richard, Manka, Jason T, Rodriguez, Alice L, Vinson, Paige N, Niswender, Colleen M, Weaver, C. David, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W, Stauffer, Shaun R

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Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu5) von Turlington, Mark, Malosh, Chrysa, Jacobs, Jon, Manka, Jason T, Noetzel, Meredith J, Vinson, Paige N, Jadhav, Satyawan, Herman, Elizabeth J, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M, Conde-Ceide, Susana, Martín-Martín, M. Luz, Tong, Han Min, López, Silvia, MacDonald, Gregor J, Steckler, Thomas, Daniels, J. Scott, Weaver, C. David, Niswender, Colleen M, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W, Stauffer, Shaun R

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The Role of Aldehyde Oxidase and Xanthine Oxidase in the Biotransformation of a Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 von Morrison, Ryan D., Blobaum, Anna L., Byers, Frank W., Santomango, Tammy S., Bridges, Thomas M., Stec, Donald, Brewer, Katrina A., Sanchez-Ponce, Raymundo, Corlew, Melany M., Rush, Roger, Felts, Andrew S., Manka, Jason, Bates, Brittney S., Venable, Daryl F., Rodriguez, Alice L., Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A., Daniels, J. Scott

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Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1 von Manka, Jason T., Rodriguez, Alice L., Morrison, Ryan D., Venable, Daryl F., Cho, Hyekyung P., Blobaum, Anna L., Daniels, J. Scott, Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Emmitte, Kyle A.

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Optimization of an ether series of mGlu5 positive allosteric modulators: Molecular determinants of MPEP-site interaction crossover von Manka, Jason T., Vinson, Paige N., Gregory, Karen J., Zhou, Ya, Williams, Richard, Gogi, Kiran, Days, Emily, Jadhav, Satya, Herman, Elizabeth J., Lavreysen, Hilde, Mackie, Claire, Bartolomé, José M., Macdonald, Gregor J., Steckler, Thomas, Daniels, J. Scott, Weaver, C. David, Niswender, Colleen M., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.

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Discovery of N-Aryl Piperazines as Selective mGluR5 Potentiators with Improved In Vivo Utility von Zhou, Ya, Manka, Jason T, Rodriguez, Alice L, Weaver, C. David, Days, Emily L, Vinson, Paige N, Jadhav, Satyawan, Hermann, Elizabeth J, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W, Stauffer, Shaun R

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Azo Group-Assisted Nucleophilic Aromatic Substitutions in Haloarene Derivatives:  Preparation of Substituted 1-Iodo-2,6-bispropylthiobenzenes von Manka, Jason T, McKenzie, Virginia C, Kaszynski, Piotr

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Synthesis of Polyfunctionalized Biphenyls as Intermediates for a New Class of Liquid Crystals von Manka, Jason T, Guo, Fengli, Huang, Jianping, Yin, Huiyong, Farrar, John M, Sienkowska, Monika, Benin, Vladimir, Kaszynski, Piotr

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Synthesis and thiolation of 1,3-difluoro-2,4,6-trihaloanilines and benzenes von Manka, Jason T, Kaszynski, Piotr

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Retro Diels−Alder Reactions of 5,6-Disubstituted-7-oxabicyclo[2.2.1]hept-2-enes:  Experimental and Density Functional Theory Studies von Manka, Jason T, Douglass, Andrew G, Kaszynski, Piotr, Friedli, Andrienne C

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2,2-Dimethylcyclopropyl-benzamides: Novel positive allosteric modulators of α7 nAChRs von Maag, Hans, Bois, Daisy Joe Du, Loughhead, David G., Manka, Jason, Misner, Dinah, Sahdeo, Sunil, Smith, David B.

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Synthesis and SAR of centrally active mGlu sub(5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold) von Williams, Richard, Manka, Jason T, Rodriguez, Alice L, Vinson, Paige N, Niswender, Colleen M, Weaver, CDavid, Jones, Carrie K, Conn, PJeffrey, Lindsley, Craig W, Stauffer, Shaun R

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Synthesis and SAR of centrally active mGlu 5 positive allosteric modulators based on an aryl acetylenic bicyclic lactam scaffold von Williams, Richard, Manka, Jason T., Rodriguez, Alice L., Vinson, Paige N., Niswender, Colleen M., Weaver, C. David, Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.

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Novel hexahydropyrrolo[3,4- c]pyrrole CCR5 antagonists von Rotstein, David M., Melville, Chris R., Padilla, Fernando, Cournoyer, Dick, Lee, Eun K., Lemoine, Remy, Petersen, Ann C., Setti, Lina Q., Wanner, Jutta, Chen, Lijing, Filonova, Lubov, Loughhead, David G., Manka, Jason, Lin, Xiao-Fa, Gleason, Shelley, Sankuratri, Surya, Ji, Changhua, deRosier, Andre, Dioszegi, Marianna, Heilek, Gabrielle, Jekle, Andreas, Berry, Pamela, Mau, Cheng-I, Weller, Paul

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Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity von Zhou, Ya, Manka, Jason T, Rodriguez, Alice L, Weaver, C David, Days, Emily L, Vinson, Paige N, Jadhav, Satyawan, Hermann, Elizabeth J, Jones, Carrie K, Conn, P Jeffrey, Lindsley, Craig W, Stauffer, Shaun R

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Discovery of N -Aryl Piperazines as Selective mGluR 5 Potentiators with Improved In Vivo Utility von Zhou, Ya, Manka, Jason T., Rodriguez, Alice L., Weaver, C. David, Days, Emily L., Vinson, Paige N., Jadhav, Satyawan, Hermann, Elizabeth J., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.

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Synthesis and Thiolation of 1,3-Difluoro-2,4,6-trihaloanilines and Benzenes von Manka, Jason T., Kaszynski, Piotr

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CYCLOPROPYL ARYL AMIDE DERIVATIVES AND USES THEREOF von MANKA, JASON, LOUGHHEAD, DAVID GARRETT, SMITH, DAVID BERNARD, DU BOIS, DAISY JOE, HURST, DAVID NIGEL, MAAG, HANS

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