Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents von Rohloff, John C, Gelinas, Amy D, Jarvis, Thale C, Ochsner, Urs A, Schneider, Daniel J, Gold, Larry, Janjic, Nebojsa

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Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets von Davies, Douglas R, Gelinas, Amy D, Zhang, Chi, Rohloff, John C, Carter, Jeffrey D, O’Connell, Daniel, Waugh, Sheela M, Wolk, Steven K, Mayfield, Wesley S, Burgin, Alex B, Edwards, Thomas E, Stewart, Lance J, Gold, Larry, Janjic, Nebojsa, Jarvis, Thale C

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Protein signature of lung cancer tissues von Mehan, Michael R, Ayers, Deborah, Thirstrup, Derek, Xiong, Wei, Ostroff, Rachel M, Brody, Edward N, Walker, Jeffrey J, Gold, Larry, Jarvis, Thale C, Janjic, Nebojsa, Baird, Geoffrey S, Wilcox, Sheri K

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Chemically Modified DNA Aptamers Bind Interleukin-6 with High Affinity and Inhibit Signaling by Blocking Its Interaction with Interleukin-6 Receptor von Gupta, Shashi, Hirota, Masao, Waugh, Sheela M., Murakami, Ikuo, Suzuki, Tomoki, Muraguchi, Masahiro, Shibamori, Masafumi, Ishikawa, Yuichi, Jarvis, Thale C., Carter, Jeffrey D., Zhang, Chi, Gawande, Bharat, Vrkljan, Michael, Janjic, Nebojsa, Schneider, Daniel J.

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Reimagining scientific conferences-a Keystone Symposia report von Weiman, Shannon, Cable, Jennifer, Greenleaf, Walter, Rundel, Felix, Whitfield, Kate E, Wingate, Lory, Gallagher, Richard, Pesanelli, Jennifer, Orr, Dereck, Jarvis, Thale C, Cadar, Raluca, Uva, Matthew D', Ruediger, Dylan, Vaez, Robert, Frisby, Adam, Ahmed, Sami, Donoviel, Dorit, Klinman, Judith, Johnson, Debbie

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Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand von Gelinas, Amy D., Davies, Douglas R., Edwards, Thomas E., Rohloff, John C., Carter, Jeffrey D., Zhang, Chi, Gupta, Shashi, Ishikawa, Yuichi, Hirota, Masao, Nakaishi, Yuichiro, Jarvis, Thale C., Janjic, Nebojsa

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Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent von De Groote, Mary A, Jackson, Mary, Gonzalez-Juarrero, Mercedes, Li, Wei, Young, Casey L, Wong, Christina, Graham, James, Day, Joshua, Hoang, Teresa, Jarvis, Thale C, Ribble, Wendy, Sun, Xicheng, Ochsner, Urs A

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Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiot... von Lomeli, Barbara K, Galbraith, Hal, Schettler, Jared, Saviolakis, George A, El-Amin, Wael, Osborn, Blaire, Ravel, Jacques, Hazleton, Keith, Lozupone, Catherine A, Evans, Ronald J, Bell, Stacie J, Ochsner, Urs A, Jarvis, Thale C, Baqar, Shahida, Janjic, Nebojsa

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Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor von Jarvis, Thale C., Davies, Douglas R., Hisaminato, Akihiko, Resnicow, Daniel I., Gupta, Shashi, Waugh, Sheela M., Nagabukuro, Akira, Wadatsu, Takashi, Hishigaki, Haretsugu, Gawande, Bharat, Zhang, Chi, Wolk, Steven K., Mayfield, Wesley S., Nakaishi, Yuichiro, Burgin, Alex B., Stewart, Lance J., Edwards, Thomas E., Gelinas, Amy D., Schneider, Daniel J., Janjic, Nebojsa

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Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study von Nayak, Seema U, Griffiss, J McLeod, Blumer, Jeffrey, O'Riordan, Mary Ann, Gray, Wesley, McKenzie, Robin, Jurao, Robert A, An, Amanda T, Le, Melissa, Bell, Stacie J, Ochsner, Urs A, Jarvis, Thale C, Janjic, Nebojsa, Zenilman, Jonathan M

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Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3 von Ochsner, Urs A., De Groote, Mary A., Jarvis, Thale C., Liu, Hang, Youmans, Tessa, Hoang, Teresa, Ribble, Wendy, Day, Joshua, Li, Wei, Pearce, Camron, Walz, Amanda, Panthi, Chandra M., Rimal, Binayak, Stevens, Casey M., Zgurskaya, Helen I., Jackson, Mary, Ordway, Diane, Gonzalez-Juarrero, Mercedes, Sun, Xicheng, Lamichhane, Gyanu, Mason, Clifford

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Structure of PolC reveals unique DNA binding and fidelity determinants von Evans, Ronald J, Davies, Douglas R, Bullard, James M, Christensen, Jeffrey, Green, Louis S, Guiles, Joseph W, Pata, Janice D, Ribble, Wendy K, Janjic, Nebojsa, Jarvis, Thale C

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Discovery and Analysis of 4H-Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors von RIBBLE, Wendy, HILL, Walter E, OCHSNER, Urs A, JARVIS, Thale C, GUILES, Joseph W, JANJIC, Nebojsa, BULLARD, James M

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Inhibition of Methionyl-tRNA Synthetase by REP8839 and Effects of Resistance Mutations on Enzyme Activity von GREEN, Louis S, BULLARD, James M, RIBBLE, Wendy, DEAN, Frank, AYERS, David F, OCHSNER, Urs A, JANJIC, Nebojsa, JARVIS, Thale C

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Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infections von Critchley, Ian A., Green, Louis S., Young, Casey L., Bullard, James M., Evans, Ron J., Price, Melissa, Jarvis, Thale C., Guiles, Joseph W., Janjic, Nebojsa, Ochsner, Urs A.

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Reimagining scientific conferences during the pandemic and beyond von Jarvis, Thale, Weiman, Shannon, Johnson, Deborah

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Reconstitution of a Minimal DNA Replicase from Pseudomonas aeruginosa and Stimulation by Non-cognate Auxiliary Factors von Jarvis, Thale C, Beaudry, Amber A, Bullard, James M, Janjic, Nebojsa, McHenry, Charles S

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Aptamer-based multiplexed proteomic technology for biomarker discovery von Gold, Larry, Ayers, Deborah, Bertino, Jennifer, Bock, Christopher, Bock, Ashley, Brody, Edward N, Carter, Jeff, Dalby, Andrew B, Eaton, Bruce E, Fitzwater, Tim, Flather, Dylan, Forbes, Ashley, Foreman, Trudi, Fowler, Cate, Gawande, Bharat, Goss, Meredith, Gunn, Magda, Gupta, Shashi, Halladay, Dennis, Heil, Jim, Heilig, Joe, Hicke, Brian, Husar, Gregory, Janjic, Nebojsa, Jarvis, Thale, Jennings, Susan, Katilius, Evaldas, Keeney, Tracy R, Kim, Nancy, Koch, Tad H, Kraemer, Stephan, Kroiss, Luke, Le, Ngan, Levine, Daniel, Lindsey, Wes, Lollo, Bridget, Mayfield, Wes, Mehan, Mike, Mehler, Robert, Nelson, Sally K, Nelson, Michele, Nieuwlandt, Dan, Nikrad, Malti, Ochsner, Urs, Ostroff, Rachel M, Otis, Matt, Parker, Thomas, Pietrasiewicz, Steve, Resnicow, Daniel I, Rohloff, John, Sanders, Glenn, Sattin, Sarah, Schneider, Daniel, Singer, Britta, Stanton, Martin, Sterkel, Alana, Stewart, Alex, Stratford, Suzanne, Vaught, Jonathan D, Vrkljan, Mike, Walker, Jeffrey J, Watrobka, Mike, Waugh, Sheela, Weiss, Allison, Wilcox, Sheri K, Wolfson, Alexey, Wolk, Steven K, Zhang, Chi, Zichi, Dom

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Potency of the novel PolC DNA polymerase inhibitor CRS0540 in a disseminated Listeria monocytogenes intracellular hollow-fibre model von Patel, Swati, Chapagain, Moti, Mason, Clifford, Gingrich, Matthew, Athale, Shruti, Ribble, Wendy, Hoang, Teresa, Day, Joshua, Sun, Xicheng, Jarvis, Thale, Ochsner, Urs A, Howe, David, Gumbo, Tawanda

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Discovery of benzothiazole amides as potent antimycobacterial agents von Graham, James, Wong, Christina E., Day, Joshua, McFaddin, Elizabeth, Ochsner, Urs, Hoang, Teresa, Young, Casey L., Ribble, Wendy, DeGroote, Mary A., Jarvis, Thale, Sun, Xicheng

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