Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target von Long, Thavy, Rojo-Arreola, Liliana, Shi, Da, El-Sakkary, Nelly, Jarnagin, Kurt, Rock, Fernando, Meewan, Maliwan, Rascón, Jr, Alberto A, Lin, Lin, Cunningham, Katherine A, Lemieux, George A, Podust, Larissa, Abagyan, Ruben, Ashrafi, Kaveh, McKerrow, James H, Caffrey, Conor R

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Linking Phenotype to Kinase: Identification of a Novel Benzoxaborole Hinge-Binding Motif for Kinase Inhibition and Development of High-Potency Rho Kinase Inhibitors von Akama, Tsutomu, Dong, Chen, Virtucio, Charlotte, Sullivan, David, Zhou, Yasheen, Zhang, Yong-Kang, Rock, Fernando, Freund, Yvonne, Liu, Liang, Bu, Wei, Wu, Anne, Fan, Xiao-Qing, Jarnagin, Kurt

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Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis von NARE, Bakela, WRING, Stephen, HUSSAIN, Ali, JARNAGIN, Kurt, JENKS, Matthew, KAISER, Marcel, MERCER, Luke, MEJIA, Elena, NOE, Andy, ORR, Matt, PARHAM, Robin, PLATTNER, Jacob, BACCHI, Cyrus, RANDOLPH, Ryan, RATTENDI, Donna, REWERTS, Cindy, SLIGAR, Jessica, YARLETT, Nigel, DON, Robert, JACOBS, Robert, BEAUDET, Beth, BOWLING, Tana, BRUN, Reto, DAITAO CHEN, DING, Charles, FREUND, Yvonne, GAUKEL, Eric

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Discovery and structure–activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents von Akama, Tsutomu, Dong, Chen, Virtucio, Charlotte, Freund, Yvonne R., Chen, Daitao, Orr, Matthew D., Jacobs, Robert T., Zhang, Yong-Kang, Hernandez, Vincent, Liu, Yang, Wu, Anne, Bu, Wei, Liu, Liang, Jarnagin, Kurt, Plattner, Jacob J.

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The liver pharmacological and xenobiotic gene response repertoire von Natsoulis, Georges, Pearson, Cecelia I, Gollub, Jeremy, P Eynon, Barrett, Ferng, Joe, Nair, Ramesh, Idury, Radha, Lee, May D, Fielden, Mark R, Brennan, Richard J, Roter, Alan H, Jarnagin, Kurt

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Animal models for SARS-Cov2/Covid19 research-A commentary von Jarnagin, Kurt, Alvarez, Oscar, Shresta, Sujan, Webb, David R.

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Monomeric Monocyte Chemoattractant Protein-1 (MCP-1) Binds and Activates the MCP-1 Receptor CCR2B von Paavola, C D, Hemmerich, S, Grunberger, D, Polsky, I, Bloom, A, Freedman, R, Mulkins, M, Bhakta, S, McCarley, D, Wiesent, L, Wong, B, Jarnagin, K, Handel, T M

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Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin A... von Dong, Chen, Virtucio, Charlotte, Zemska, Olga, Baltazar, Grober, Zhou, Yasheen, Baia, Diogo, Jones-Iatauro, Shannon, Sexton, Holly, Martin, Shamra, Dee, Joshua, Mak, Yvonne, Meewan, Maliwan, Rock, Fernando, Akama, Tsutomu, Jarnagin, Kurt

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SARS-CoV-2 Delta requires human ACE2 but not human TMPRSS2 to infect mice and elicits greater lung injury and adaptive immune response than Omicron in human ACE2 knock-in mice von Verma, Shailendra Kumar, Ana-Sosa-Batiz, Fernanda, Shafee, Norazizah, Timis, Julia, Maule, Erin, Miller, Robyn, Pinto, Paolla DA, Valentine, Kristen, Conner, Chris, Webb, Devid, Jarnagin, Kurt, Kim, Kenneth, Shresta, Sujan

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A precisely humanized FCRN transgenic mouse for preclinical pharmacokinetics studies von Conner, Christopher M., van Fossan, Don, Read, Kristen, Cowley, Dale O., Alvarez, Oscar, Xu, Shannon Xiang-Ru, Webb, David R., Jarnagin, Kurt

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Considerations for development of therapies for cutaneous neurofibroma von Verma, Sharad K, Riccardi, Vincent M, Plotkin, Scott R, Weinberg, Hubert, Anderson, R Rox, Blakeley, Jaishri O, Jarnagin, Kurt, Lee, James

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Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center von Freund, Yvonne R., Akama, Tsutomu, Alley, M.R.K., Antunes, Joana, Dong, Chen, Jarnagin, Kurt, Kimura, Richard, Nieman, James A., Maples, Kirk R., Plattner, Jacob J., Rock, Fernando, Sharma, Rashmi, Singh, Rajeshwar, Sanders, Virginia, Zhou, Yasheen

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Clinical trial design for cutaneous neurofibromas von Cannon, Ashley, Jarnagin, Kurt, Korf, Bruce, Widemann, Brigitte C, Casey, Denise, Ko, Hon-Sum, Blakeley, Jaishri O, Verma, Sharad K, Pichard, Dominique C

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Extracellular Domains of the Bradykinin B2 Receptor Involved in Ligand Binding and Agonist Sensing Defined by Anti-peptide Antibodies (∗) von Alla, Said Abd, Quitterer, Ursula, Grigoriev, Stella, Maidhof, Armin, Haasemann, Martina, Jarnagin, Kurt, Müller-Esterl, Werner

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Influence of Th1 versus Th2 immune bias on viral, pathological, and immunological dynamics in SARS-CoV-2 variant-infected human ACE2 knock-in mice von Verma, Shailendra Kumar, Ana-Sosa-Batiz, Fernanda, Timis, Julia, Shafee, Norazizah, Maule, Erin, Pinto, Paolla Beatriz Almeida, Conner, Chris, Valentine, Kristen M., Cowley, Dale O., Miller, Robyn, Elong Ngono, Annie, Tran, Linda, Varghese, Krithik, Dos Santos Alves, Rúbens Prince, Hastie, Kathryn M., Saphire, Erica Ollmann, Webb, David R., Jarnagin, Kurt, Kim, Kenneth, Shresta, Sujan

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Mutations in the B2 Bradykinin Receptor Reveal a Different Pattern of Contacts for Peptidic Agonists and Peptidic Antagonists von Jarnagin, Kurt, Bhakta, Sunil, Zuppan, Patty, Yee, Calvin, Ho, Teresa, Phan, Thu, Tahilramani, Ram, Pease, JoeH.B., Miller, Aaron, Freedman, Richard

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Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action von Ganter, Brigitte, Tugendreich, Stuart, Pearson, Cecelia I., Ayanoglu, Eser, Baumhueter, Susanne, Bostian, Keith A., Brady, Lindsay, Browne, Leslie J., Calvin, John T., Day, Gwo-Jen, Breckenridge, Naiomi, Dunlea, Shane, Eynon, Barrett P., Furness, L. Mike, Ferng, Joe, Fielden, Mark R., Fujimoto, Susan Y., Gong, Li, Hu, Christopher, Idury, Radha, Judo, Michael S.B., Kolaja, Kyle L., Lee, May D., McSorley, Christopher, Minor, James M., Nair, Ramesh V., Natsoulis, Georges, Nguyen, Peter, Nicholson, Simone M., Pham, Hang, Roter, Alan H., Sun, Dongxu, Tan, Siqi, Thode, Silke, Tolley, Alexander M., Vladimirova, Antoaneta, Yang, Jian, Zhou, Zhiming, Jarnagin, Kurt

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AN2728, a new boron-based topical anti-inflammatory agent, inhibits phosphodiesterase 4 (IRC4P.611) von Freund, Yvonne, Dong, Chen, Virtucio-Frates, Charlotte, Rock, Fernando, Mak, Yvonne, Zhou, Yasheen, Zane, Lee, Jarnagin, Kurt

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Influence of Th1 versus Th2 immune bias on viral, pathological, and immunological dynamics in SARS-CoV-2 variant-infected human ACE2 knock-in miceResearch in context von Shailendra Kumar Verma, Fernanda Ana-Sosa-Batiz, Julia Timis, Norazizah Shafee, Erin Maule, Paolla Beatriz Almeida Pinto, Chris Conner, Kristen M. Valentine, Dale O. Cowley, Robyn Miller, Annie Elong Ngono, Linda Tran, Krithik Varghese, Rúbens Prince Dos Santos Alves, Kathryn M. Hastie, Erica Ollmann Saphire, David R. Webb, Kurt Jarnagin, Kenneth Kim, Sujan Shresta

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Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 von El-Sakkary, Nelly, Podust, Larissa, Long, Thavy, Rojo-Arreola, Liliana, McKerrow, James H, Lin, Lin, Jarnagin, Kurt, Meewan, Maliwan, Cunningham, Katherine A, Ashrafi, Kaveh, Abagyan, Ruben, Rock, Fernando, Shi, Da, Lemieux, George A, Caffrey, Conor R, Rascón, Alberto A

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