Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12) von Navia-Paldanius, Dina, Savinainen, Juha R., Laitinen, Jarmo T.

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Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A) von Savinainen, Juha R, Patel, Jayendra Z, Parkkari, Teija, Navia-Paldanius, Dina, Marjamaa, Joona J T, Laitinen, Tuomo, Nevalainen, Tapio, Laitinen, Jarmo T

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Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12) von Parkkari, Teija, Haavikko, Raisa, Laitinen, Tuomo, Navia-Paldanius, Dina, Rytilahti, Roosa, Vaara, Miia, Lehtonen, Marko, Alakurtti, Sami, Yli-Kauhaluoma, Jari, Nevalainen, Tapio, Savinainen, Juha R, Laitinen, Jarmo T

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Synthesis and preclinical evaluation of [11C]MA-PB-1 for in vivo imaging of brain monoacylglycerol lipase (MAGL) von Ahamed, Muneer, Attili, Bala, van Veghel, Daisy, Ooms, Maarten, Berben, Philippe, Celen, Sofie, Koole, Michel, Declercq, Lieven, Savinainen, Juha R., Laitinen, Jarmo T., Verbruggen, Alfons, Bormans, Guy

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An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A 1 and cannabinoid CB 1 receptors von Savinainen, Juha R, Saario, Susanna M, Niemi, Riku, Järvinen, Tomi, Laitinen, Jarmo T

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Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) von Korhonen, Jani, Kuusisto, Anne, van Bruchem, John, Patel, Jayendra Z., Laitinen, Tuomo, Navia-Paldanius, Dina, Laitinen, Jarmo T., Savinainen, Juha R., Parkkari, Teija, Nevalainen, Tapio J.

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Robust Hydrolysis of Prostaglandin Glycerol Esters by Human Monoacylglycerol Lipase (MAGL) von Savinainen, Juha R., Kansanen, Emilia, Pantsar, Tatu, Navia-Paldanius, Dina, Parkkari, Teija, Lehtonen, Marko, Laitinen, Tuomo, Nevalainen, Tapio, Poso, Antti, Levonen, Anna-Liisa, Laitinen, Jarmo T.

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Chiral 1,3,4-Oxadiazol-2-ones as Highly Selective FAAH Inhibitors von Patel, Jayendra Z, Parkkari, Teija, Laitinen, Tuomo, Kaczor, Agnieszka A, Saario, Susanna M, Savinainen, Juha R, Navia-Paldanius, Dina, Cipriano, Mariateresa, Leppänen, Jukka, Koshevoy, Igor O, Poso, Antti, Fowler, Christopher J, Laitinen, Jarmo T, Nevalainen, Tapio

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Evaluation of FASN inhibitors by a versatile toolkit reveals differences in pharmacology between human and rodent FASN preparations and in antiproliferative efficacy in vitro vs. i... von Singha, Prosanta K., Mäklin, Kiira, Vihavainen, Taina, Laitinen, Tuomo, Nevalainen, Tapio J., Patil, Mahadeo R., Tonduru, Arun K., Poso, Antti, Laitinen, Jarmo T., Savinainen, Juha R.

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Quantification of lysophosphatidic acids in rat brain tissue by liquid chromatography–electrospray tandem mass spectrometry von Aaltonen, Niina, Laitinen, Jarmo T., Lehtonen, Marko

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The basic secretagogue compound 48/80 activates G proteins indirectly via stimulation of phospholipase D–lysophosphatidic acid receptor axis and 5‐HT 1A receptors in rat brain sect... von Palomäki, Ville A B, Laitinen, Jarmo T

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A Sensitive and Versatile Fluorescent Activity Assay for ABHD6 von Savinainen, Juha R., Navia-Paldanius, Dina, Laitinen, Jarmo T.

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A Sensitive and Versatile Fluorescent Activity Assay for ABHD12 von Savinainen, Juha R., Navia-Paldanius, Dina, Laitinen, Jarmo T.

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A Randomized Clinical Trial of Histamine 2 Receptor Antagonism in Treatment-Resistant Schizophrenia von MESKANEN, Katarina, EKELUND, Heidi, LAITINEN, Jarmo, NEUVONEN, Pertti J, HAUKKA, Jari, PANULA, Pertti, EKELUND, Jesper

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In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048) von Aaltonen, Niina, Kedzierska, Ewa, Orzelska-Górka, Jolanta, Lehtonen, Marko, Navia-Paldanius, Dina, Jakupovic, Hermina, Savinainen, Juha R., Nevalainen, Tapio, Laitinen, Jarmo T., Parkkari, Teija, Gynther, Mikko

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Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors von Pantsar, Tatu, Singha, Prosanta, Nevalainen, Tapio J., Koshevoy, Igor, Leppänen, Jukka, Poso, Antti, Niskanen, Juha M.A., Pasonen-Seppänen, Sanna, Savinainen, Juha R., Laitinen, Tuomo, Laitinen, Jarmo T.

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Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists von Yrjölä, Sari, Parkkari, Teija, Navia-Paldanius, Dina, Laitinen, Tuomo, Kaczor, Agnieszka A., Kokkola, Tarja, Adusei-Mensah, Frank, Savinainen, Juha R., Laitinen, Jarmo T., Poso, Antti, Alexander, Amy, Penman, June, Stott, Lisa, Anskat, Marie, Irving, Andrew J., Nevalainen, Tapio J.

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Loratadine analogues as MAGL inhibitors von Patel, Jayendra Z., Ahenkorah, Stephen, Vaara, Miia, Staszewski, Marek, Adams, Yahaya, Laitinen, Tuomo, Navia-Paldanius, Dina, Parkkari, Teija, Savinainen, Juha R., Walczyński, Krzysztof, Laitinen, Jarmo T., Nevalainen, Tapio J.

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Revisiting 1,3,4-Oxadiazol-2-ones: Utilization in the Development of ABHD6 Inhibitors von Patel, Jayendra Z., van Bruchem, John, Laitinen, Tuomo, Kaczor, Agnieszka A., Navia-Paldanius, Dina, Parkkari, Teija, Savinainen, Juha R., Laitinen, Jarmo T., Nevalainen, Tapio J.

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Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase von Navia-Paldanius, Dina, Aaltonen, Niina, Lehtonen, Marko, Savinainen, Juha R., Taschler, Ulrike, Radner, Franz P.W., Zimmermann, Robert, Laitinen, Jarmo T.

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