Tracking genome engineering outcome at individual DNA breakpoints von Certo, Michael T, Ryu, Byoung Y, Annis, James E, Garibov, Mikhail, Jarjour, Jordan, Rawlings, David J, Scharenberg, Andrew M

Volltext

The design and in vivo evaluation of engineered I-OnuI-based enzymes for HEG gene drive von Chan, Yuk-Sang, Takeuchi, Ryo, Jarjour, Jordan, Huen, David S, Stoddard, Barry L, Russell, Steven

Volltext

Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases von Baxter, Sarah, Lambert, Abigail R, Kuhar, Ryan, Jarjour, Jordan, Kulshina, Nadia, Parmeggiani, Fabio, Danaher, Patrick, Gano, Jacob, Baker, David, Stoddard, Barry L, Scharenberg, Andrew M

Volltext

Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance von Romano Ibarra, Guillermo S, Paul, Biswajit, Sather, Blythe D, Younan, Patrick M, Sommer, Karen, Kowalski, John P, Hale, Malika, Stoddard, Barry, Jarjour, Jordan, Astrakhan, Alexander, Kiem, Hans-Peter, Rawlings, David J

Volltext

megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering von Boissel, Sandrine, Jarjour, Jordan, Astrakhan, Alexander, Adey, Andrew, Gouble, Agnès, Duchateau, Philippe, Shendure, Jay, Stoddard, Barry L, Certo, Michael T, Baker, David, Scharenberg, Andrew M

Volltext

Pediatric and young adult leukemia adoptive therapy (PLAT)-08: A phase 1 study of SC-DARIC33 in pediatric and young adults with relapsed or refractory CD33+ AML von Cooper, Todd Michael, Wu, Vicky, Wilson, Ashley, Appelbaum, Jacob, Jarjour, Jordan, Gustafson, Josh, Mgebroff, Stephanie, Lindgren, Catherine, Brown, Christopher, Jensen, Michael C., Park, Julie R., Gardner, Rebecca Alice

Volltext

Fanconi anemia gene editing by the CRISPR/Cas9 system von Osborn, Mark J, Gabriel, Richard, Webber, Beau R, DeFeo, Anthony P, McElroy, Amber N, Jarjour, Jordan, Starker, Colby G, Wagner, John E, Joung, J Keith, Voytas, Daniel F, von Kalle, Christof, Schmidt, Manfred, Blazar, Bruce R, Tolar, Jakub

Volltext

323. Efficient Generation of CART Cells by Homology Directed Transgene Integration into the TCR-Alpha Locus von Lee, Baeckseung, Leung, Hang, Jarjour, Jordan, Astrakhan, Alexander

Volltext

Drug-regulated CD33-targeted CAR T cells control AML using clinically optimized rapamycin dosing von Appelbaum, Jacob, Price, April E, Oda, Kaori, Zhang, Joy, Leung, Wai-Hang, Tampella, Giacomo, Xia, Dong, So, Pauline Pl, Hilton, Sarah K, Evandy, Claudya, Sarkar, Semanti, Martin, Unja, Krostag, Anne-Rachel, Leonardi, Marissa, Zak, Daniel E, Logan, Rachael, Lewis, Paula, Franke-Welch, Secil, Ngwenyama, Njabulo, Fitzgerald, Michael, Tulberg, Niklas, Rawlings-Rhea, Stephanie, Gardner, Rebecca A, Jones, Kyle, Sanabria, Angelica, Crago, William, Timmer, John, Hollands, Andrew, Eckelman, Brendan, Bilic, Sanela, Woodworth, Jim, Lamble, Adam, Gregory, Philip D, Jarjour, Jordan, Pogson, Mark, Gustafson, Joshua A, Astrakhan, Alexander, Jensen, Michael C

Volltext

LAHEDES: the LAGLIDADG homing endonuclease database and engineering server von Taylor, Gregory K, Petrucci, Lucas H, Lambert, Abigail R, Baxter, Sarah K, Jarjour, Jordan, Stoddard, Barry L

Volltext

Abstract 3756: Efficient generation of CAR T cells by site-specific gene addition into the TRAC locus von Lee, Baeckseung, Leung, Wai-Hang, Pogson, Mark, Jarjour, Jordan, Astrakhan, Alexander

Volltext

Abstract 1708: Effective and reversible control of anti-tumor activity in vivo with a drug-regulated CAR T cell platform (DARIC) von Leung, Wai-Hang, Certo, Michael, Horton, Holly, Gay, Joel, VandenBerg, Tracy, Jarjour, Jordan, Astrakhan, Alexander

Volltext

Clinical Translation of SC-DARIC33: A Pharmacologically Controlled CD33-Targeted Anti-AML CAR T Cell Product Regulated By Low Nanomolar Concentrations of Rapamycin von Appelbaum, Jacob S., Price, April, Zhang, Joy, Oda, Kaori, Sundaram, Sumati, Lewis, Paula, Bilic, Sanela, Tampella, Giacomo, Xia, Dong, Krostag, Anne-Rachel, So, Pauline, Martin, Unja, Leung, Wai-Hang, Astrakhan, Alexander, Pogson, Mark, Jarjour, Jordan, Gustafson, Josh, Jensen, Michael CV

Volltext

A Drug-Regulated CAR Platform (DARIC) Induces Effective and Reversible Tumor Control In Vivo Using Non-Immunosuppressive Rapamycin Dosing von Leung, Wai-Hang, Certo, Michael T, Horton, Holly M., Gay, Joel, VandenBerg, Tracy, Jarjour, Jordan, Astrakhan, Alexander

Volltext

Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity von Werther, Rachel, Hallinan, Jazmine P, Lambert, Abigail R, Havens, Kyle, Pogson, Mark, Jarjour, Jordan, Galizi, Roberto, Windbichler, Nikolai, Crisanti, Andrea, Nolan, Tony, Stoddard, Barry L

Volltext

Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization von Leung, Wai-Hang, Gay, Joel, Martin, Unja, Garrett, Tracy E, Horton, Holly M, Certo, Michael T, Blazar, Bruce R, Morgan, Richard A, Gregory, Philip D, Jarjour, Jordan, Astrakhan, Alexander

Volltext

277. Small Molecule-Regulated Antigen Recognition System for Inducible T Cell Targeting of Cancer Cells von Leung, Wai-Hang, Certo, Michael, Horton, Holly, Diaconu, Iulia, VandenBerg, Tracy, Jarjour, Jordan, Astrakhan, Alexander

Volltext

Knockout of CBLB Greatly Enhances Anti-Tumor Activity of CAR T Cells von Hooper, Kathryn, Havens, Kyle, Krostag, Anne-Rachel, Magee, Michael S, Martin, Unja, Gupta, Ankit, Smurnyy, Yegor, Pechilis, Lisa, Rode, Amanda, Chavkin, Andrew, Grande, Shannon, Morgan, Richard A., Jarjour, Jordan, Astrakhan, Alexander

Volltext

Exploitation of binding energy for catalysis and design von Baker, David, Takeuchi, Ryo, Scharenberg, Andrew M, Jarjour, Jordan, Havranek, James J, Thyme, Summer B, Stoddard, Barry L, Ashworth, Justin

Volltext

Gene Editing of TRAC Locus Utilizing Megatal Nucleases Increases Expression of Transgenic TCRs Delivered Via Lentiviral Vector-Mediated Gene Transfer von Magee, Michael S, Diaconu, Iulia, Pogson, Mark, Gupta, Ankit, Jensen-Smith, Amy, Collette, Brian, Chavkin, Andrew, Pasackow, Eli, Edwards, Aaron, Friedman, Kevin M., Astrakhan, Alexander, Certo, Michael T, Jarjour, Jordan, Morgan, Richard A.

Volltext