β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes von BUTLER, Alexandra E, JANSON, Juliette, BONNER-WEIR, Susan, RITZEL, Robert, RIZZA, Robert A, BUTLER, Peter C

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Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease von Jeppsson, Fredrik, Eketjäll, Susanna, Janson, Juliette, Karlström, Sofia, Gustavsson, Susanne, Olsson, Lise-Lotte, Radesäter, Ann-Cathrine, Ploeger, Bart, Cebers, Gvido, Kolmodin, Karin, Swahn, Britt-Marie, von Berg, Stefan, Bueters, Tjerk, Fälting, Johanna

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Increased Risk of Type 2 Diabetes in Alzheimer Disease von JANSON, Juliette, LAEDTKE, Thomas, PARISI, Joseph E, O'BRIEN, Peter, PETERSEN, Ronald C, BUTLER, Peter C

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Intravenous delivery of a chemically modified sulfamidase efficiently reduces heparan sulfate storage and brain pathology in mucopolysaccharidosis IIIA mice von Gustavsson, Susanne, Ohlin Sjöström, Elisabet, Tjernberg, Agneta, Janson, Juliette, Westermark, Ulrica, Andersson, Tommy, Makower, Åsa, Arnelöf, Erik, Andersson, Gudrun, Svartengren, Jan, Ekholm, Carina, Svensson Gelius, Stefan

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Impact of chemical modification of sulfamidase on distribution to brain interstitial fluid and to CSF after an intravenous administration in awake, freely-moving rats von Janson, Juliette, Andersson, Gudrun, Bergquist, Lars, Eriksson, Maria, Folgering, Joost H.A.

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An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function von Johansson, Jenny U, Ericsson, Jesper, Janson, Juliette, Beraki, Simret, Stanić, Davor, Mandic, Slavena A, Wikström, Martin A, Hökfelt, Tomas, Ogren, Sven Ove, Rozell, Björn, Berggren, Per-Olof, Bark, Christina

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Tomosyn Is Expressed in β-Cells and Negatively Regulates Insulin Exocytosis von WEI ZHANG, LILJA, Lena, MANDIC, Slavena A, GROMADA, Jesper, SMIDT, Kamille, JANSON, Juliette, TAKAI, Yoshimi, BARK, Christina, BERGGREN, Per-Olof, MEISTER, Björn

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Neuronal Calcium Sensor-1 Potentiates Glucose-Dependent Exocytosis in Pancreatic β Cells through Activation of Phosphatidylinositol 4-Kinase β von Gromada, Jesper, Bark, Christina, Smidt, Kamille, Efanov, Alexander M., Janson, Juliette, Mandic, Slavena A., Webb, Dominic-Luc, Zhang, Wei, Meister, Björn, Jeromin, Andreas, Berggren, Per-Olof, Luft, Rolf

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AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics von Eketjall, S, Janson, J, Kaspersson, K, Bogstedt, A, Jeppsson, F, Falting, J, Haeberlein, SB, Kugler, AR, Alexander, RC, Cebers, G

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Distribution of chemically modified rhSulfamidase to CNS monitored by brain microdialysis and repeated CSF sampling after intravenous administration in rat von Janson, Juliette, Andersson, Gudrun, Bergquist, Lars, Eriksson, Maria, Folgering, Joost H.A.

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Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β von HENDERSON, Simon J, ANDERSSON, Christin, FRESKGARD, Per Ola, JERMUTUS, Lutz, BURRELL, Matthew, FOWLER, Susan B, WEBSTER, Carl I, NARWAL, Rajesh, JANSON, Juliette, GOLDSCHMIDT, Tom J, APPELKVIST, Paulina, BOGSTEDT, Anna, ANN-CHARLOTT, Steffen, HAUPTS, Ulrich, TEBBE, Jan

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Increased β-cell apoptosis prevents adaptive increase in β-cell mass in mouse model of type 2 diabetes: Evidence for role of islet amyloid formation rather than direct action of am... von BUTLER, Alexandra E, JANSON, Juliette, SOELLER, Walter C, BUTLER, Peter C

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Sulfonimidamides as Sulfonamides Bioisosteres: Rational Evaluation through Synthetic, in Vitro, and in Vivo Studies with γ-Secretase Inhibitors von Sehgelmeble, Fernando, Janson, Juliette, Ray, Colin, Rosqvist, Susanne, Gustavsson, Susanne, Nilsson, Linda I., Minidis, Alexander, Holenz, Jörg, Rotticci, Didier, Lundkvist, Johan, Arvidsson, Per I.

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New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain von Gravenfors, Ylva, Viklund, Jenny, Blid, Jan, Ginman, Tobias, Karlström, Sofia, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, von Berg, Stefan, von Kieseritzky, Fredrik, Slivo, Can, Swahn, Britt-Marie, Olsson, Lise-Lotte, Johansson, Patrik, Eketjäll, Susanna, Fälting, Johanna, Jeppsson, Fredrik, Strömberg, Kia, Janson, Juliette, Rahm, Fredrik

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Design and Synthesis of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β‑Amyloid Peptides von Swahn, Britt-Marie, Kolmodin, Karin, Karlström, Sofia, von Berg, Stefan, Söderman, Peter, Holenz, Jörg, Berg, Stefan, Lindström, Johan, Sundström, Marie, Turek, Dominika, Kihlström, Jacob, Slivo, Can, Andersson, Lars, Pyring, David, Rotticci, Didier, Öhberg, Liselotte, Kers, Annika, Bogar, Krisztian, von Kieseritzky, Fredrik, Bergh, Margareta, Olsson, Lise-Lotte, Janson, Juliette, Eketjäll, Susanna, Georgievska, Biljana, Jeppsson, Fredrik, Fälting, Johanna

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Robust LC–MS/MS methods for analysis of heparan sulfate levels in CSF and brain for application in studies of MPS IIIA von Makower, Åsa, Arnelöf, Erik, Andersson, Tommy, Edlund, Per-Olof, Gustavsson, Susanne, Janson, Juliette, Gelius, Stefan Svensson, Tjernberg, Agneta

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AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice von Eketjäll, Susanna, Janson, Juliette, Jeppsson, Fredrik, Svanhagen, Alexander, Kolmodin, Karin, Gustavsson, Susanne, Radesäter, Ann-Cathrin, Eliason, Kristina, Briem, Sveinn, Appelkvist, Paulina, Niva, Camilla, Berg, Anna-Lena, Karlström, Sofia, Swahn, Britt-Marie, Fälting, Johanna

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Increased β-Cell Apoptosis Prevents Adaptive Increase in β-Cell Mass in Mouse Model of Type 2 Diabetes von Butler, Alexandra E., Janson, Juliette, Soeller, Walter C., Butler, Peter C.

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Population PKPD Modeling of BACE1 Inhibitor-Induced Reduction in A[beta] Levels In Vivo and Correlation to In Vitro Potency in Primary Cortical Neurons from Mouse and Guinea Pig von Janson, Juliette, Eketjäll, Susanna, Tunblad, Karin, Jeppsson, Fredrik, Von Berg, Stefan, Niva, Camilla, Radesäter, Ann-cathrin, Fälting, Johanna, Visser, Sandra A, G

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Population PKPD Modeling of BACE1 Inhibitor-Induced Reduction in Aβ Levels In Vivo and Correlation to In Vitro Potency in Primary Cortical Neurons from Mouse and Guinea Pig von Janson, Juliette, Eketjäll, Susanna, Tunblad, Karin, Jeppsson, Fredrik, Von Berg, Stefan, Niva, Camilla, Radesäter, Ann-Cathrin, Fälting, Johanna, Visser, Sandra A. G.

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