Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist von Spaulding, Caitlin N., Klein, Roger D., Ruer, Ségolène, Kau, Andrew L., Schreiber, Henry L., Cusumano, Zachary T., Dodson, Karen W., Pinkner, Jerome S., Fremont, Daved H., Janetka, James W., Remaut, Han, Gordon, Jeffrey I., Hultgren, Scott J.

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Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics von Ma, Cynthia X, Janetka, James W, Piwnica-Worms, Helen

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MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A von Rocha, Agostinho G, Franco, Antonietta, Krezel, Andrzej M, Rumsey, Jeanne M, Alberti, Justin M, Knight, William C, Biris, Nikolaos, Zacharioudakis, Emmanouil, Janetka, James W, Baloh, Robert H, Kitsis, Richard N, Mochly-Rosen, Daria, Townsend, R Reid, Gavathiotis, Evripidis, Dorn, 2nd, Gerald W

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A FimH Inhibitor Prevents Acute Bladder Infection and Treats Chronic Cystitis Caused by Multidrug-Resistant Uropathogenic Escherichia coli ST131 von Totsika, Makrina, Kostakioti, Maria, Hannan, Thomas J., Upton, Mathew, Beatson, Scott A., Janetka, James W., Hultgren, Scott J., Schembri, Mark A.

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A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis von McLellan, Lisa K, McAllaster, Michael R, Kim, Arthur S, Tóthová, Ľubomíra, Olson, Patrick D, Pinkner, Jerome S, Daugherty, Allyssa L, Hreha, Teri N, Janetka, James W, Fremont, Daved H, Hultgren, Scott J, Virgin, Herbert W, Hunstad, David A

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Lead Optimization Studies on FimH Antagonists: Discovery of Potent and Orally Bioavailable Ortho-Substituted Biphenyl Mannosides von Han, Zhenfu, Pinkner, Jerome S, Ford, Bradley, Chorell, Erik, Crowley, Jan M, Cusumano, Corinne K, Campbell, Scott, Henderson, Jeffrey P, Hultgren, Scott J, Janetka, James W

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AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies von Zabludoff, Sonya D, Deng, Chun, Grondine, Michael R, Sheehy, Adam M, Ashwell, Susan, Caleb, Benjamin L, Green, Stephen, Haye, Heather R, Horn, Candice L, Janetka, James W, Liu, Dongfang, Mouchet, Elizabeth, Ready, Shannon, Rosenthal, Judith L, Queva, Christophe, Schwartz, Gary K, Taylor, Karen J, Tse, Archie N, Walker, Graeme E, White, Anne M

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Combinatorial Small-Molecule Therapy Prevents Uropathogenic Escherichia coli Catheter-Associated Urinary Tract Infections in Mice von GUITON, Pascale S, CUSUMANO, Corinne K, KLINE, Kimberly A, DODSON, Karen W, ZHENFU HAN, JANETKA, James W, HENDERSON, Jeffrey P, CAPARON, Michael G, HULTGREN, Scott J

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Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets von Franco, Francisco M., Jones, Darin E., Harris, Peter K.W., Han, Zhenfu, Wildman, Scott A., Jarvis, Cassie M., Janetka, James W.

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Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins von Budelier, Melissa M, Cheng, Wayland W. L, Bergdoll, Lucie, Chen, Zi-Wei, Abramson, Jeff, Krishnan, Kathiresan, Qian, Mingxing, Covey, Douglas F, Janetka, James W, Evers, Alex S

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Distinguishing the Contribution of Type 1 Pili from That of Other QseB-Misregulated Factors when QseC Is Absent during Urinary Tract Infection von KOSTAKIOTI, Maria, HADJIFRANGISKOU, Maria, CUSUMANO, Corinne K, HANNAN, Thomas J, JANETKA, James W, HULTGREN, Scott J

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Aspartyl Protease Inhibitors as Anti-Filarial Drugs von Beld, Liana, Jung, Hyeim, Bulman, Christina A., Rosa, Bruce A., Fischer, Peter U., Janetka, James W., Lustigman, Sara, Sakanari, Judy A., Mitreva, Makedonka

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Keeping checkpoint kinases in line: new selective inhibitors in clinical trials von Ashwell, Susan, Janetka, James W, Z abludoff, Sonya

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Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer von Han, Zhenfu, Harris, Peter K. W, Jones, Darin E, Chugani, Ryan, Kim, Tommy, Agarwal, Manjula, Shen, Wei, Wildman, Scott A, Janetka, James W

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An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease von Tyagi, Rahul, Bulman, Christina A, Cho-Ngwa, Fidelis, Fischer, Chelsea, Marcellino, Chris, Arkin, Michelle R, McKerrow, James H, McNamara, Case W, Mahoney, Matthew, Tricoche, Nancy, Jawahar, Shabnam, Janetka, James W, Lustigman, Sara, Sakanari, Judy, Mitreva, Makedonka

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Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine von Kawaguchi, Makiko, Yamamoto, Koji, Takeda, Naoki, Fukushima, Tsuyoshi, Yamashita, Fumiki, Sato, Katsuaki, Kitamura, Kenichiro, Hippo, Yoshitaka, Janetka, James W., Kataoka, Hiroaki

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Mechanism-Based Macrocyclic Inhibitors of Serine Proteases von Damalanka, Vishnu C., Banas, Victoria, De Bona, Paolo, Kashipathy, Maithri M., Battaile, Kevin, Lovell, Scott, Janetka, James W.

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Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections von Maddirala, Amarendar Reddy, Tamadonfar, Kevin, Pinkner, Jerome S., Sanick, Denise, Hultgren, Scott J., Janetka, James W.

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A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells von Mahoney, Matthew, Damalanka, Vishnu C., Tartell, Michael A., Chung, Dong hee, Lourenço, André Luiz, Pwee, Dustin, Bridwell, Anne E. Mayer, Hoffmann, Markus, Voss, Jorine, Karmakar, Partha, Azouz, Nurit P., Klingler, Andrea M., Rothlauf, Paul W., Thompson, Cassandra E., Lee, Melody, Klampfer, Lidija, Stallings, Christina L., Rothenberg, Marc E., Pöhlmann, Stefan, Whelan, Sean P. J., O’Donoghue, Anthony J., Craik, Charles S., Janetka, James W.

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Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis von Janetka, James W, Hopper, Allen T, Yang, Ziping, Barks, Jennifer, Dhason, Mary Savari, Wang, Qiuling, Sibley, L David

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