Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys von Chen, Yali, Amantana, Adams, Tyavanagimatt, Shanthakumar R, Zima, Daniela, Yan, X Steven, Kasi, Gopi, Weeks, Morgan, Stone, Melialani A, Weimers, William C, Samuel, Peter, Tan, Ying, Jones, Kevin F, Lee, Daniel R, Kickner, Shirley S, Saville, Bradley M, Lauzon, Martin, McIntyre, Alan, Honeychurch, Kady M, Jordan, Robert, Hruby, Dennis E, Leeds, Janet M

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Transient or extended reversal of apixaban anticoagulation by andexanet alfa is equally effective in a porcine polytrauma model von Grottke, Oliver, Braunschweig, Till, Rossaint, Rolf, Akman, Necib, Leeds, Janet M., Conley, Pamela B., Honickel, Markus

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Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model von Lu, Genmin, Pine, Polly, Leeds, Janet M, DeGuzman, Francis, Pratikhya, Pratikhya, Lin, Joyce, Malinowski, John, Hollenbach, Stanley J, Curnutte, John T, Conley, Pamela B

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Novel Benzoxazole Inhibitor of Dengue Virus Replication That Targets the NS3 Helicase von BYRD, Chelsea M, GROSENBACH, Douglas W, WINEINGER, Kristin A, PAGE, Jessica, STAVALE, Eric, STONE, Melialani A, FULLER, Kathleen P, LOVEJOY, Candace, LEEDS, Janet M, HRUBY, Dennis E, JORDAN, Robert, BERHANU, Aklile, DONGCHENG DAI, JONES, Kevin F, CARDWELL, Kara B, SCHNEIDER, Christine, GUANG YANG, TYAVANAGIMATT, Shanthakumar, HARVER, Chris

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Development of ST-246® for Treatment of Poxvirus Infections von Jordan, Robert, Leeds, Janet M, Tyavanagimatt, Shanthakumar, Hruby, Dennis E

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Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity von Siegal, Deborah M, Curnutte, John T, Connolly, Stuart J, Lu, Genmin, Conley, Pamela B, Wiens, Brian L, Mathur, Vandana S, Castillo, Janice, Bronson, Michele D, Leeds, Janet M, Mar, Florie A, Gold, Alex, Crowther, Mark A

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Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers von CHINSANGARAM, Jarasvech, HONEYCHURCH, Kady M, ROSS, Eric, LICHTENSTEIN, Israel, PICKENS, Margaret, CORRADO, Michael, CLARKE, Jean M, FRIMM, Annie M, HRUBY, Dennis E, TYAVANAGIMATT, Shanthakumar R, LEEDS, Janet M, BOLKEN, Tove' C, JONES, Kevin F, JORDAN, Robert, MARBURY, Thomas, RUCKLE, Jon, MEE-LEE, Denis

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Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa von Siegal, Deborah, Lu, Genmin, Leeds, Janet M., Karbarz, Mark, Castillo, Janice, Mathur, Vandana, Hutchaleelaha, Athiwat, Sinha, Uma, Kitt, Michael, McClure, Matt, Hollenbach, Stanley J., Curnutte, John T., Conley, Pamela B., Crowther, Mark

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Pharmacokinetic and Pharmacodynamic Modeling To Determine the Dose of ST-246 To Protect against Smallpox in Humans von LEEDS, Janet M, FENNETEAU, Frederique, CHINSANGARAM, Jarasvech, TYAVANAGIMATT, Shanthakumar R, HRUBY, Dennis E, JORDAN, Robert, GOSSELIN, Nathalie H, MOUKSASSI, Mohamad-Samer, KASSIR, Nastya, MARIER, J. F, YALI CHEN, GROSENBACH, Doug, FRIMM, Annie E, HONEYCHURCH, Kady M

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Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection von Amantana, Adams, Chen, Yali, Tyavanagimatt, Shanthakumar R, Jones, Kevin F, Jordan, Robert, Chinsangaram, Jarasvech, Bolken, Tove C, Leeds, Janet M, Hruby, Dennis E

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First‐in‐Human Evaluation of Safety, Pharmacokinetics and Muscle Glycogen Lowering of a Novel Glycogen Synthase 1 Inhibitor for the Treatment of Pompe Disease von Ullman, Julie C., Dick, Ryan A., Linzner, Daniela, Minga, Todd, Tep, Samnang, Satterfield, Terrence F., Xi, Yannan, Beattie, David T., Marmon, Tonya, Neutel, Joel M., Chung, Bernard, Leeds, Janet M., Noonberg, Sarah B., Green, Eric M., Bernstein, Harold S.

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Cerdulatinib Pharmacodynamics and Relationships to Tumor Response Following Oral Dosing in Patients with Relapsed/Refractory B-cell Malignancies von Coffey, Greg P, Feng, Jiajia, Betz, Andreas, Pandey, Anjali, Birrell, Matt, Leeds, Janet M, Der, Kenneth, Kadri, Sabah, Lu, Pin, Segal, Jeremy, Wang, Y Lynn, Michelson, Glenn, Curnutte, John T, Conley, Pamela B

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The Safety and Efficacy of Full Versus Reduced Dose Betrixaban in the Acute Medically Ill VTE (Venous Thromboembolism) Prevention with Extended Duration Betrixaban (APEX) Trial von Gibson, C. Michael, Halaby, Rim, Korjian, Serge, Daaboul, Yazan, Arbetter, Douglas F, Yee, Megan K, Goldhaber, Samuel Z, Hull, Russel, Hernandez, Adrian F, Gold, Alex, Wiens, Brian, Leeds, Janet, Harrington, Robert A, Cohen, Alexander T

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Efficacy and safety of the dual SYK/JAK inhibitor cerdulatinib in patients with relapsed or refractory B‐cell malignancies: Results of a phase I study von Hamlin, Paul A., Flinn, Ian W., Wagner‐Johnston, Nina, Burger, Jan A., Coffey, Greg P., Conley, Pamela B., Michelson, Glenn, Leeds, Janet M., Der, Kenneth, Kim, Yvonne, Sabalvaro‐Torres, Alice, Birrell, Matt, Pandey, Anjali, Curnutte, John T., Patel, Manish R.

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A phase 2 PK/PD study of andexanet alfa for reversal of rivaroxaban and edoxaban anticoagulation in healthy volunteers von Lu, Genmin, Conley, Pamela B., Leeds, Janet M., Karbarz, Mark J., Levy, Gallia G., Mathur, Vandana S., Castillo, Janice, Crowther, Mark, Curnutte, John T.

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Andexanet Alfa Reverses Anticoagulation Effects of Enoxaparin and Associated Bleeding in a Rabbit Acute Hemorrhage Model von Pine, Polly, Lu, Genmin, Canivel, Deogracias, Pratikhya, Pratikhya, DeGuzman, Francis, Karbarz, Mark, Takeda, Kentaro, Malinowski, John, Leeds, Janet M., Curnutte, John T., Conley, Pamela B.

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Comparison of pharmacokinetics and tissue disposition of an antisense phosphorothioate oligonucleotide targeting human Ha‐ras mRNA in mouse and monkey von Yu, Rosie Z., Geary, Richard S., Leeds, Janet M., Watanabe, Tanya, Moore, Max, Fitchett, Jon, Matson, John, Burckin, Todd, Templin, Michael V., Levin, Arthur A.

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Synthesis of AZT 5‘-Triphosphate Mimics and Their Inhibitory Effects on HIV-1 Reverse Transcriptase von Wang, Guangyi, Boyle, Nicholas, Chen, Fu, Rajappan, Vasanthakumar, Fagan, Patrick, Brooks, Jennifer L, Hurd, Tiffany, Leeds, Janet M, Rajwanshi, Vivek K, Jin, Yi, Prhavc, Marija, Bruice, Thomas W, Cook, P. Dan

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Synthesis of 2‘,3‘-Dideoxynucleoside 5‘-α-P-Borano-β,γ-(difluoromethylene)triphosphates and Their Inhibition of HIV-1 Reverse Transcriptase von Boyle, Nicholas A, Rajwanshi, Vivek K, Prhavc, Marija, Wang, Guangyi, Fagan, Patrick, Chen, Fu, Ewing, Gregory J, Brooks, Jennifer L, Hurd, Tiffany, Leeds, Janet M, Bruice, Thomas W, Cook, P. Dan

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Inhibition of Human Immunodeficiency Virus Type 1 Infection in SCID-hu Thy/Liv Mice by the G-Quartet-Forming Oligonucleotide, ISIS 5320 von STODDART, C. A, RABIN, L, HINCENBERGS, M, MORENO, M. E, LINQUIST-STEPPS, V, LEEDS, J. M, LO ANNE TRUONG, WYATT, J. R, ECKER, D. J, MCCUNE, J. M

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