Transgenic animal models in toxicology: historical perspectives and future outlook von Boverhof, Darrell R, Chamberlain, Mark P, Elcombe, Clifford R, Gonzalez, Frank J, Heflich, Robert H, Hernández, Lya G, Jacobs, Abigail C, Jacobson-Kram, David, Luijten, Mirjam, Maggi, Adriana, Manjanatha, Mugimane G, Benthem, Jan van, Gollapudi, B Bhaskar

Volltext

Strategies in genotoxicology: Acceptance of innovative scientific methods in a regulatory context and from an industrial perspective von Steiblen, Guy, Benthem, Jan van, Johnson, George

Volltext

Hazardous compounds in tobacco smoke von Talhout, Reinskje, Schulz, Thomas, Florek, Ewa, van Benthem, Jan, Wester, Piet, Opperhuizen, Antoon

Volltext

Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose–response data: Margin of exposure case study of 48 compounds with both in vivo mutageni... von Chepelev, Nikolai, Long, Alexandra S., Beal, Marc, Barton‐Maclaren, Tara, Johnson, George, Dearfield, Kerry L., Roberts, Daniel J., Benthem, Jan, White, Paul

Volltext

Interlaboratory validation of the ToxTracker assay: An in vitro reporter assay for mechanistic genotoxicity assessment von Hendriks, Giel, Adriaens, Els, Allemang, Ashley, Clements, Julie, Cole, Gabrielle, Derr, Remco, Engel, Maria, Hamel, Annie, Kidd, Darren, Kellum, Stephanie, Kiyota, Tomomi, Myhre, Abby, Naëssens, Valerie, Pfuhler, Stefan, Roy, Marise, Settivari, Raja, Schuler, Maik, Zeller, Andreas, Benthem, Jan, Vanparys, Philippe, Kirkland, David

Volltext

Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach von Hernández, Lya G., van Steeg, Harry, Luijten, Mirjam, van Benthem, Jan

Volltext

Application of the adverse outcome pathway framework to genotoxic modes of action von Sasaki, Jennifer C., Allemang, Ashley, Bryce, Steven M., Custer, Laura, Dearfield, Kerry L., Dietz, Yasmin, Elhajouji, Azeddine, Escobar, Patricia A., Fornace, Albert J., Froetschl, Roland, Galloway, Sheila, Hemmann, Ulrike, Hendriks, Giel, Li, Heng‐Hong, Luijten, Mirjam, Ouedraogo, Gladys, Peel, Lauren, Pfuhler, Stefan, Roberts, Daniel J., Thybaud, Véronique, Benthem, Jan, Yauk, Carole L., Schuler, Maik

Volltext

In utero Exposure to Genotoxicants Leading to Genetic Mosaicism: An Overlooked Window of Susceptibility in Genetic Toxicology Testing? von Godschalk, Roger W. L., Yauk, Carole L., Benthem, Jan, Douglas, George R., Marchetti, Francesco

Volltext

Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review von Douglas, George R., Beevers, Carol, Gollapudi, Bhaskar, Keig‐Shevlin, Zena, Kirkland, David, O'Brien, Jason M., Benthem, Jan, Yauk, Carole L., Young, Robert R., Marchetti, Francesco

Volltext

Utility of a next generation framework for assessment of genomic damage: A case study using the industrial chemical benzene von Luijten, Mirjam, Ball, Nicholas S., Dearfield, Kerry L., Gollapudi, B. Bhaskar, Johnson, George E., Madia, Federica, Peel, Lauren, Pfuhler, Stefan, Settivari, Raja S., Burg, Wouter, White, Paul A., Benthem, Jan

Volltext

Main issues addressed in the 2014–2015 revisions to the OECD Genetic Toxicology Test Guidelines von Thybaud, Veronique, Lorge, Elisabeth, Levy, Dan D., Benthem, Jan, Douglas, George R., Marchetti, Francesco, Moore, Martha M., Schoeny, Rita, Gibbons, Catherine

Volltext

Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488 von Marchetti, Francesco, Aardema, Marilyn, Beevers, Carol, van Benthem, Jan, Douglas, George R., Godschalk, Roger, Yauk, Carole L., Young, Robert, Williams, Andrew

Volltext

A mode-of-action approach for the identification of genotoxic carcinogens von Hernández, Lya G, van Benthem, Jan, Johnson, George E

Volltext

ECVAM retrospective validation of in vitro micronucleus test (MNT) von Corvi, Raffaella, Albertini, Silvio, Hartung, Thomas, Hoffmann, Sebastian, Maurici, Daniela, Pfuhler, Stefan, van Benthem, Jan, Vanparys, Philippe

Volltext

Clarification of some aspects related to genotoxicity assessment von Hardy, Anthony, Benford, Diane, Halldorsson, Thorhallur, Jeger, Michael, Knutsen, Helle Katrine, More, Simon, Naegeli, Hanspeter, Noteborn, Hubert, Ockleford, Colin, Ricci, Antonia, Rychen, Guido, Silano, Vittorio, Solecki, Roland, Turck, Dominique, Younes, Maged, Aquilina, Gabriele, Crebelli, Riccardo, Gürtler, Rainer, Hirsch‐Ernst, Karen Ildico, Mosesso, Pasquale, Nielsen, Elsa, van Benthem, Jan, Carfì, Maria, Georgiadis, Nikolaos, Maurici, Daniela, Parra Morte, Juan, Schlatter, Josef

Volltext

Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data von Woutersen, Ruud A., Soffers, Ans E.M.F., Kroese, E. Dinant, Krul, Cyrille A.M., van der Laan, Jan Willem, van Benthem, Jan, Luijten, Mirjam

Volltext

Comparison of clastogen-induced gene expression profiles in wild-type and DNA repair-deficient Rad54/Rad54B cells von Mahabir, Anuska G, Schaap, Mirjam M, Pennings, Jeroen L A, van Benthem, Jan, Hendriksen, Coenraad F M, van Steeg, Harry

Volltext

Differential Contributions of Mammalian Rad54 Paralogs to Recombination, DNA Damage Repair, and Meiosis von Wesoly, Joanna, Agarwal, Sheba, Sigurdsson, Stefan, Bussen, Wendy, Van Komen, Stephen, Qin, Jian, van Steeg, Harry, van Benthem, Jan, Wassenaar, Evelyne, Baarends, Willy M., Ghazvini, Mehrnaz, Tafel, Agnieszka A., Heath, Helen, Galjart, Niels, Essers, Jeroen, Grootegoed, J. Anton, Arnheim, Norman, Bezzubova, Olga, Buerstedde, Jean-Marie, Sung, Patrick, Kanaar, Roland

Volltext

Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities—Report from an ECVAM workshop von Pfuhler, Stefan, Kirkland, David, Kasper, Peter, Hayashi, Makoto, Vanparys, Philippe, Carmichael, Paul, Dertinger, Stephen, Eastmond, David, Elhajouji, Azeddine, Krul, Cyrille, Rothfuss, Andreas, Schoening, Gabriele, Smith, Andrew, Speit, Guenter, Thomas, Claire, van Benthem, Jan, Corvi, Raffaella

Volltext

Approaches for identifying germ cell mutagens: Report of the 2013 IWGT workshop on germ cell assays von Yauk, Carole L., Aardema, Marilyn J., Benthem, Jan van, Bishop, Jack B., Dearfield, Kerry L., DeMarini, David M., Dubrova, Yuri E., Honma, Masamitsu, Lupski, James R., Marchetti, Francesco, Meistrich, Marvin L., Pacchierotti, Francesca, Stewart, Jane, Waters, Michael D., Douglas, George R.

Volltext