Novel therapies emerging in oncology to target the TGF-β pathway von Kim, Byung-Gyu, Malek, Ehsan, Choi, Sung Hee, Ignatz-Hoover, James J, Driscoll, James J

Volltext

Deciphering mechanisms of immune escape to inform immunotherapeutic strategies in multiple myeloma von Swamydas, Muthulekha, Murphy, Elena V, Ignatz-Hoover, James J, Malek, Ehsan, Driscoll, James J

Volltext

The TGFβ type I receptor kinase inhibitor vactosertib in combination with pomalidomide in relapsed/refractory multiple myeloma: a phase 1b trial von Malek, Ehsan, Rana, Priyanka S., Swamydas, Muthulekha, Daunov, Michael, Miyagi, Masaru, Murphy, Elena, Ignatz-Hoover, James J., Metheny, Leland, Kim, Seong Jin, Driscoll, James J.

Volltext

Targeting Proteasomes and the MHC Class I Antigen Presentation Machinery to Treat Cancer, Infections and Age-Related Diseases von Rana, Priyanka S, Ignatz-Hoover, James J, Driscoll, James J

Volltext

Targeting Proteasomes in Cancer and Infectious Disease: A Parallel Strategy to Treat Malignancies and Microbes von Ignatz-Hoover, James J, Murphy, Elena V, Driscoll, James J

Volltext

Current and Emerging Strategies to Treat Urothelial Carcinoma von Rani, Berkha, Ignatz-Hoover, James J, Rana, Priyanka S, Driscoll, James J

Volltext

Therapeutics to harness the immune microenvironment in multiple myeloma von Ignatz-Hoover, James J., Driscoll, James J.

Volltext

Circulating CD4+ and CD8+ T cells are activated in inflammatory bowel disease and are associated with plasma markers of inflammation von Funderburg, Nicholas T., Stubblefield Park, Samantha R., Sung, Hannah C., Hardy, Gareth, Clagett, Brian, Ignatz‐Hoover, James, Harding, Clifford V., Fu, Pingfu, Katz, Jeffry A., Lederman, Michael M., Levine, Alan D.

Volltext

HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity von Rana, Priyanka S, Ignatz-Hoover, James J, Kim, Byung-Gyu, Malek, Ehsan, Federov, Yuriy, Adams, Drew, Chan, Timothy, Driscoll, James J

Volltext

Phase I Trial of Lithium and Tretinoin for Treatment of Relapsed and Refractory Non-promyelocytic Acute Myeloid Leukemia von Ueda, Masumi, Stefan, Tammy, Stetson, Lindsay, Ignatz-Hoover, James J, Tomlinson, Benjamin, Creger, Richard J, Cooper, Brenda, Lazarus, Hillard M, de Lima, Marcos, Wald, David N, Caimi, Paolo F

Volltext

GSK-3 Inhibition Sensitizes Acute Myeloid Leukemia Cells to 1,25D-Mediated Differentiation von Gupta, Kalpana, Stefan, Tammy, Ignatz-Hoover, James, Moreton, Stephen, Parizher, Gary, Saunthararajah, Yogen, Wald, David N

Volltext

A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity von Hu, Sophia, Ueda, Masumi, Stetson, Lindsay, Ignatz-Hoover, James, Moreton, Stephen, Chakrabarti, Amit, Xia, Zhiqiang, Karan, Goutam, de Lima, Marcos, Agrawal, Mukesh K, Wald, David N

Volltext

Aberrant GSK3β nuclear localization promotes AML growth and drug resistance von Ignatz-Hoover, James J., Wang, Victoria, Mackowski, Nathan M., Roe, Anne J., Ghansah, Isaac K., Ueda, Masumi, Lazarus, Hillard M., de Lima, Marcos, Paietta, Elisabeth, Fernandez, Hugo, Cripe, Larry, Tallman, Martin, Wald, David N.

Volltext

Emerging Strategies to Manage Relapsed and/or Refractory Multiple Myeloma von Driscoll, James J, Ignatz-Hoover, James

Volltext

An Immunoproteasome Activator That Increases MHC Class I Antigen Presentation to Enhance Anti-Tumor Immunity von Driscoll, James J., Rana, Priyanka S., Malek, Ehsan, Ignatz-Hoover, James J.

Volltext

HDAC6 Inhibition Activates Proteasomes to Modulate the MHC Class I Immunopeptidome and Promote Antimyeloma Immunity von Rana, Priyanka S., Ignatz-Hoover, James J., Malek, Ehsan, Driscoll, James J.

Volltext

PSMC2 Overexpression Enhances Proteasome Activity, Mitigates ER Stress, and Correleates with Reduced Overall Survival in Multiple Myeloma von Ignatz-Hoover, James J., Chan, E Ricky, D'Cruz, Jack, Rana, Pryianka, Malek, Ehsan, Driscoll, James J.

Volltext

MM-501 Overexpression of Proteasome PSMC ATPases Mitigates ER Stress and Correlates With Reduced Overall Survival in Multiple Myeloma von Ignatz-Hoover, James, Rana, Priyanka, Malek, Ehsan, Driscoll, James

Volltext

P-186 Proteasome regulatory ATPase PSMC2 promotes drug resistance by mitigating ER stress and portends reduced overall survival in multiple myeloma von Driscoll, James, Ignatz-Hoover, James, Rana, Priyanka, Malek, Ehsan

Volltext

POSTER: MM-501 Overexpression of Proteasome PSMC ATPases Mitigates ER Stress and Correlates With Reduced Overall Survival in Multiple Myeloma von Ignatz-Hoover, James, Rana, Priyanka, Malek, Ehsan, Driscoll, James

Volltext