Biomarker-Guided Development of DNA Repair Inhibitors von Cleary, James M., Aguirre, Andrew J., Shapiro, Geoffrey I., D’Andrea, Alan D.

Volltext

Nivolumab plus chemotherapy or ipilimumab in gastro-oesophageal cancer von Shitara, Kohei, Ajani, Jaffer A., Moehler, Markus, Garrido, Marcelo, Gallardo, Carlos, Shen, Lin, Yamaguchi, Kensei, Wyrwicz, Lucjan, Skoczylas, Tomasz, Bragagnoli, Arinilda Campos, Liu, Tianshu, Tehfe, Mustapha, Elimova, Elena, Bruges, Ricardo, Zander, Thomas, de Azevedo, Sergio, Kowalyszyn, Ruben, Pazo-Cid, Roberto, Schenker, Michael, Cleary, James M., Yanez, Patricio, Feeney, Kynan, Karamouzis, Michalis V., Poulart, Valerie, Lei, Ming, Xiao, Hong, Kondo, Kaoru, Li, Mingshun, Janjigian, Yelena Y.

Volltext

Restoring balance to cancer pain management von Cleary, James F.

Volltext

First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, op... von Janjigian, Yelena Y, Shitara, Kohei, Moehler, Markus, Garrido, Marcelo, Salman, Pamela, Shen, Lin, Wyrwicz, Lucjan, Yamaguchi, Kensei, Skoczylas, Tomasz, Campos Bragagnoli, Arinilda, Liu, Tianshu, Schenker, Michael, Yanez, Patricio, Tehfe, Mustapha, Kowalyszyn, Ruben, Karamouzis, Michalis V, Bruges, Ricardo, Zander, Thomas, Pazo-Cid, Roberto, Hitre, Erika, Feeney, Kynan, Cleary, James M, Poulart, Valerie, Cullen, Dana, Lei, Ming, Xiao, Hong, Kondo, Kaoru, Li, Mingshun, Ajani, Jaffer A

Volltext

Randomized Trial of TAS-102 for Refractory Metastatic Colorectal Cancer von Mayer, Robert J, Van Cutsem, Eric, Falcone, Alfredo, Yoshino, Takayuki, Garcia-Carbonero, Rocio, Mizunuma, Nobuyuki, Yamazaki, Kentaro, Shimada, Yasuhiro, Tabernero, Josep, Komatsu, Yoshito, Sobrero, Alberto, Boucher, Eveline, Peeters, Marc, Tran, Ben, Lenz, Heinz-Josef, Zaniboni, Alberto, Hochster, Howard, Cleary, James M, Prenen, Hans, Benedetti, Fabio, Mizuguchi, Hirokazu, Makris, Lukas, Ito, Masanobu, Ohtsu, Atsushi

Volltext

Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer von Kelly, Ronan J, Ajani, Jaffer A, Kuzdzal, Jaroslaw, Zander, Thomas, Van Cutsem, Eric, Piessen, Guillaume, Mendez, Guillermo, Feliciano, Josephine, Motoyama, Satoru, Lièvre, Astrid, Uronis, Hope, Elimova, Elena, Grootscholten, Cecile, Geboes, Karen, Zafar, Syed, Snow, Stephanie, Ko, Andrew H, Feeney, Kynan, Schenker, Michael, Kocon, Piotr, Zhang, Jenny, Zhu, Lili, Lei, Ming, Singh, Prianka, Kondo, Kaoru, Cleary, James M, Moehler, Markus

Volltext

Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study von Bekaii-Saab, Tanios S, Prof, Ou, Fang-Shu, PhD, Ahn, Daniel H, DO, Boland, Patrick M, MD, Ciombor, Kristen K, MD, Heying, Erica N, BS, Dockter, Travis J, MS, Jacobs, Nisha L, MD, Pasche, Boris C, Prof, Cleary, James M, MD, Meyers, Jeffrey P, BS, Desnoyers, Rodwige J, MD, McCune, Jeannine S, Prof, Pedersen, Katrina, MD, Barzi, Afsaneh, MD, Chiorean, E Gabriela, Prof, Sloan, Jeffrey, Prof, Lacouture, Mario E, Prof, Lenz, Heinz-Josef, Prof, Grothey, Axel, MD

Volltext

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer von Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew W., Williams, Hannah L., DenAdel, Alan, Lowder, Kristen E., Galvez-Reyes, Jennyfer, Kalekar, Radha L., Mulugeta, Nolawit, Kapner, Kevin S., Raghavan, Manisha S., Borah, Ashir A., Liu, Nuo, Väyrynen, Sara A., Costa, Andressa Dias, Ng, Raymond W.S., Wang, Junning, Hill, Emma K., Ragon, Dorisanne Y., Brais, Lauren K., Jaeger, Alex M., Spurr, Liam F., Li, Yvonne Y., Cherniack, Andrew D., Booker, Matthew A., Cohen, Elizabeth F., Tolstorukov, Michael Y., Wakiro, Isaac, Rotem, Asaf, Johnson, Bruce E., McFarland, James M., Sicinska, Ewa T., Jacks, Tyler E., Sullivan, Ryan J., Shapiro, Geoffrey I., Clancy, Thomas E., Perez, Kimberly, Rubinson, Douglas A., Ng, Kimmie, Cleary, James M., Crawford, Lorin, Manalis, Scott R., Nowak, Jonathan A., Wolpin, Brian M., Hahn, William C., Aguirre, Andrew J., Shalek, Alex K.

Volltext

Availability of Internationally Controlled Essential Medicines in the COVID-19 Pandemic von Pettus, Katherine, Cleary, James F., de Lima, Liliana, Ahmed, Ebtesam, Radbruch, Lukas

Volltext

Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study von Abou-Alfa, Ghassan K, Macarulla, Teresa, Javle, Milind M, Kelley, Robin K, Lubner, Sam J, Adeva, Jorge, Cleary, James M, Catenacci, Daniel V, Borad, Mitesh J, Bridgewater, John, Harris, William P, Murphy, Adrian G, Oh, Do-Youn, Whisenant, Jonathan, Lowery, Maeve A, Goyal, Lipika, Shroff, Rachna T, El-Khoueiry, Anthony B, Fan, Bin, Wu, Bin, Chamberlain, Christina X, Jiang, Liewen, Gliser, Camelia, Pandya, Shuchi S, Valle, Juan W, Zhu, Andrew X

Volltext

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration von Liu, Peng, Reed, Miranda N., Kotilinek, Linda A., Grant, Marianne K.O., Forster, Colleen L., Qiang, Wei, Shapiro, Samantha L., Reichl, John H., Chiang, Angie C.A., Jankowsky, Joanna L., Wilmot, Carrie M., Cleary, James P., Zahs, Kathleen R., Ashe, Karen H.

Volltext

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway von Viswanathan, Vasanthi S., Ryan, Matthew J., Dhruv, Harshil D., Gill, Shubhroz, Eichhoff, Ossia M., Seashore-Ludlow, Brinton, Kaffenberger, Samuel D., Eaton, John K., Shimada, Kenichi, Aguirre, Andrew J., Viswanathan, Srinivas R., Chattopadhyay, Shrikanta, Tamayo, Pablo, Yang, Wan Seok, Rees, Matthew G., Chen, Sixun, Boskovic, Zarko V., Javaid, Sarah, Huang, Cherrie, Wu, Xiaoyun, Tseng, Yuen-Yi, Roider, Elisabeth M., Gao, Dong, Cleary, James M., Wolpin, Brian M., Mesirov, Jill P., Haber, Daniel A., Engelman, Jeffrey A., Boehm, Jesse S., Kotz, Joanne D., Hon, Cindy S., Chen, Yu, Hahn, William C., Levesque, Mitchell P., Doench, John G., Berens, Michael E., Shamji, Alykhan F., Clemons, Paul A., Stockwell, Brent R., Schreiber, Stuart L.

Volltext

Costs, affordability, and feasibility of an essential package of cancer control interventions in low-income and middle-income countries: key messages from Disease Control Prioritie... von Gelband, Hellen, MHS, Sankaranarayanan, Rengaswamy, MD, Gauvreau, Cindy L, PhD, Horton, Susan, Prof, Anderson, Benjamin O, MD, Bray, Freddie, DPhil, Cleary, James, MD, Dare, Anna J, PhD, Denny, Lynette, MD, Gospodarowicz, Mary K, MD, Gupta, Sumit, MD, Howard, Scott C, Prof, Jaffray, David A, PhD, Knaul, Felicia, PhD, Levin, Carol, PhD, Rabeneck, Linda, MD, Rajaraman, Preetha, PhD, Sullivan, Terrence, PhD, Trimble, Edward L, MD, Jha, Prabhat, Prof

Volltext

SMARCA4 Mutations in Carcinomas of the Esophagus, Esophagogastric Junction, and Stomach von Neil, Alexander J., Zhao, Lei, Isidro, Raymond A., Srivastava, Amitabh, Cleary, James M., Dong, Fei

Volltext

Phase I Study of Neratinib in Combination With Temsirolimus in Patients With Human Epidermal Growth Factor Receptor 2–Dependent and Other Solid Tumors von GANDHI, Leena, BAHLEDA, Rastislav, KRYGOWSKI, Mizue, YALI LIANG, TURNBULL, Kathleen W, SHAPIRO, Geoffrey I, SORIA, Jean-Charles, TOLANEY, Sara M, KWAK, Eunice L, CLEARY, James M, PANDYA, Shuchi S, HOLLEBECQUE, Antoine, ABBAS, Richat, ANANTHAKRISHNAN, Revathi, BERKENBLIT, Anna

Volltext

Antitumour activity of neratinib in patients with HER2-mutant advanced biliary tract cancers von Harding, James J., Piha-Paul, Sarina A., Shah, Ronak H., Murphy, Jessica J., Cleary, James M., Shapiro, Geoffrey I., Quinn, David I., Braña, Irene, Moreno, Victor, Borad, Mitesh, Loi, Sherene, Spanggaard, Iben, Park, Haeseong, Ford, James M., Arnedos, Mónica, Stemmer, Salomon M., de la Fouchardiere, Christelle, Fountzilas, Christos, Zhang, Jie, DiPrimeo, Daniel, Savin, Casey, Duygu Selcuklu, S., Berger, Michael F., Eli, Lisa D., Meric-Bernstam, Funda, Jhaveri, Komal, Solit, David B., Abou-Alfa, Ghassan K.

Volltext

Immunological Checkpoint Blockade in Anal Squamous Cell Carcinoma: Dramatic Responses Tempered By Frequent Resistance von Jayakrishnan, Thejus, Yadav, Devvrat, Huffman, Brandon M., Cleary, James M.

Volltext

Caspase-2 cleavage of tau reversibly impairs memory von Zhao, Xiaohui, Kotilinek, Linda A, Smith, Benjamin, Hlynialuk, Chris, Zahs, Kathleen, Ramsden, Martin, Cleary, James, Ashe, Karen H

Volltext

A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations von Voss, Martin H, Hierro, Cinta, Heist, Rebecca S, Cleary, James M, Meric-Bernstam, Funda, Tabernero, Josep, Janku, Filip, Gandhi, Leena, Iafrate, A John, Borger, Darrell R, Ishii, Nobuya, Hu, Youyou, Kirpicheva, Yulia, Nicolas-Metral, Valerie, Pokorska-Bocci, Anna, Vaslin Chessex, Anne, Zanna, Claudio, Flaherty, Keith T, Baselga, Jose

Volltext

Effect of High-Dose vs Standard-Dose Vitamin D3 Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer: The SUNSHINE Randomized C... von Ng, Kimmie, Nimeiri, Halla S, McCleary, Nadine J, Abrams, Thomas A, Yurgelun, Matthew B, Cleary, James M, Rubinson, Douglas A, Schrag, Deborah, Miksad, Rebecca, Bullock, Andrea J, Allen, Jill, Zuckerman, Dan, Chan, Emily, Chan, Jennifer A, Wolpin, Brian M, Constantine, Michael, Weckstein, Douglas J, Faggen, Meredith A, Thomas, Christian A, Kournioti, Chryssanthi, Yuan, Chen, Ganser, Christine, Wilkinson, Brittney, Mackintosh, Christopher, Zheng, Hui, Hollis, Bruce W, Meyerhardt, Jeffrey A, Fuchs, Charles S

Volltext