Synthesis and Spectrum of the Neoglycoside ACHN-490 von AGGEN, James B, ARMSTRONG, Eliana S, LOPEZ, Sara, GOMEZ, Marcela, WLASICHUK, Kenneth B, DIOKNO, Raymond, MILLER, George H, MOSER, Heinz E, GOLDBLUM, Adam A, DOZZO, Paola, LINSELL, Martin S, GLIEDT, Micah J, HILDEBRANDT, Darin J, FEENEY, Lee Ann, KUBO, Aya, MATIAS, Rowena D

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ACHN-490, a Neoglycoside with Potent In Vitro Activity against Multidrug-Resistant Klebsiella pneumoniae Isolates von ENDIMIANI, Andrea, HUJER, Kristine M, HUJER, Andrea M, ARMSTRONG, Eliana S, CHOUDHARY, Yuvraj, AGGEN, James B, BONOMO, Robert A

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In Vivo Efficacy of the Novel Aminoglycoside ACHN-490 in Murine Infection Models von Reyes, Noe, Aggen, James B, Kostrub, Corwin F

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Toxicity Modulation, Resistance Enzyme Evasion, and A‑Site X‑ray Structure of Broad-Spectrum Antibacterial Neomycin Analogs von Maianti, Juan Pablo, Kanazawa, Hiroki, Dozzo, Paola, Matias, Rowena D, Feeney, Lee Ann, Armstrong, Eliana S, Hildebrandt, Darin J, Kane, Timothy R, Gliedt, Micah J, Goldblum, Adam A, Linsell, Martin S, Aggen, James B, Kondo, Jiro, Hanessian, Stephen

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Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth von Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal

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Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors von Burnett, G. Leslie, Yang, Yu C., Aggen, James B., Pitzen, Jennifer, Gliedt, Micah K., Semko, Chris M., Marquez, Abby, Evans, James W., Wang, Gang, Won, Walter S., Tomlinson, Aidan C. A., Kiss, Gert, Tzitzilonis, Christos, Thottumkara, Arun P., Cregg, James, Mellem, Kevin T., Choi, Jong S., Lee, Julie C., Zhao, Yongyuan, Lee, Bianca J., Meyerowitz, Justin G., Knox, John E., Jiang, Jingjing, Wang, Zhican, Wildes, David, Wang, Zhengping, Singh, Mallika, Smith, Jacqueline A. M., Gill, Adrian L.

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Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety von Cohen, Frederick, Aggen, James B., Andrews, Logan D., Assar, Zahra, Boggs, Jen, Choi, Taylor, Dozzo, Paola, Easterday, Ashton N., Haglund, Cat M., Hildebrandt, Darin J., Holt, Melissa C., Joly, Kristin, Jubb, Adrian, Kamal, Zeeshan, Kane, Timothy R., Konradi, Andrei W., Krause, Kevin M., Linsell, Martin S., Machajewski, Timothy D., Miroshnikova, Olga, Moser, Heinz E., Nieto, Vincent, Phan, Thu, Plato, Craig, Serio, Alisa W., Seroogy, Julie, Shakhmin, Anton, Stein, Adam J., Sun, Alex D., Sviridov, Serguei, Wang, Zhan, Wlasichuk, Kenneth, Yang, Wen, Zhou, Xiaoming, Zhu, Hai, Cirz, Ryan T.

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A Multivalent Approach to Drug Discovery for Novel Antibiotics von Long, Daniel D, Aggen, James B, Christensen, Burton G, Judice, J Kevin, Hegde, Sharath S, Kaniga, Koné, Krause, Kevin M, Linsell, Martin S, Moran, Edmund J, Pace, John L

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Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth von Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal

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Exploring the Positional Attachment of Glycopeptide/β-lactam Heterodimers von Long, Daniel D, Aggen, James B, Chinn, Jason, Choi, Seok-Ki, Christensen, Burton G, Fatheree, Paul R, Green, David, Hegde, Sharath S, Judice, J Kevin, Kaniga, Koné, Krause, Kevin M, Leadbetter, Michael, Linsell, Martin S, Marquess, Daniel G, Moran, Edmund J, Nodwell, Matthew B, Pace, John L, Trapp, Sean G, Turne, S Derek

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Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth von Lee, Bianca J., Boyer, Jacob A., Burnett, G. Leslie, Thottumkara, Arun P., Tibrewal, Nidhi, Wilson, Stacy L., Hsieh, Tientien, Marquez, Abby, Lorenzana, Edward G., Evans, James W., Hulea, Laura, Kiss, Gert, Liu, Hui, Lee, Dong, Larsson, Ola, McLaughlan, Shannon, Topisirovic, Ivan, Wang, Zhengping, Wang, Zhican, Zhao, Yongyuan, Wildes, David, Aggen, James B., Singh, Mallika, Gill, Adrian L., Smith, Jacqueline A. M., Rosen, Neal

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Compound design guidelines for evading the efflux and permeation barriers of Escherichia coli with the oxazolidinone class of antibacterials: Test case for a general approach to im... von Spaulding, Andrew, Takrouri, Khuloud, Mahalingam, Pornachandran, Cleary, Dillon C., Cooper, Harold D., Zucchi, Paola, Tear, Westley, Koleva, Bilyana, Beuning, Penny J., Hirsch, Elizabeth B., Aggen, James B.

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Congener-Independent Immunoassay for Microcystins and Nodularins von Fischer, Werner J, Garthwaite, Ian, Miles, Christopher O, Ross, Kathryn M, Aggen, James B, Chamberlin, A. Richard, Towers, Neale R, Dietrich, Daniel R

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Progress against Escherichia coli with the Oxazolidinone Class of Antibacterials: Test Case for a General Approach To Improving Whole-Cell Gram-Negative Activity von Takrouri, Khuloud, Cooper, Harold D, Spaulding, Andrew, Zucchi, Paola, Koleva, Bilyana, Cleary, Dillon C, Tear, Westley, Beuning, Penny J, Hirsch, Elizabeth B, Aggen, James B

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1-(4-Phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanones as novel CCR1 antagonists von Pennell, Andrew M.K., Aggen, James B., Sen, Subhabrata, Chen, Wei, Xu, Yuan, Sullivan, Edward, Li, Lianfa, Greenman, Kevin, Charvat, Trevor, Hansen, Derek, Dairaghi, Daniel J., Wright, J.J. Kim, Zhang, Penglie

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Multivalent design of long-acting β(2)-adrenoceptor agonists incorporating biarylamines von Jacobsen, John R, Aggen, James B, Church, Timothy J, Klein, Uwe, Pfeiffer, Juergen W, Pulido-Rios, Teresa M, Thomas, G Roger, Yu, Cecile, Moran, Edmund J

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A Central Strategy for Converting Natural Products into Fluorescent Probes von Alexander, Matthew D., Burkart, Michael D., Leonard, Michael S., Portonovo, Padma, Liang, Bo, Ding, Xiaobin, Joullié, Madeleine M., Gulledge, Brian M., Aggen, James B., Chamberlin, A. Richard, Sandler, Joel, Fenical, William, Cui, Jian, Gharpure, Santosh J., Polosukhin, Alexei, Zhang, Hai-Ren, Evans, P. Andrew, Richardson, Adam D., Harper, Mary Kay, Ireland, Chris M., Vong, Binh G., Brady, Thomas P., Theodorakis, Emmanuel A., La Clair, James J.

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Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue von Hanessian, Stephen, Giguère, Alexandre, Grzyb, Justyna, Maianti, Juan Pablo, Saavedra, Oscar M, Aggen, James B, Linsell, Martin S, Goldblum, Adam A, Hildebrandt, Darin J, Kane, Timothy R, Dozzo, Paola, Gliedt, Micah J, Matias, Rowena D, Feeney, Lee Ann, Armstrong, Eliana S

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Microcystin analogues comprised only of adda and a single additional amino acid retain moderate activity as PP1/PP2A inhibitors von Gulledge, Brian M, Aggen, James B, Eng, Hugo, Sweimeh, Khuloud, Chamberlin, A.Richard

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Total Synthesis of the Serine-Threonine Phosphatase Inhibitor Microcystin-LA von Humphrey, John M, Aggen, James B, Chamberlin, A. Richard

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