Low-data interpretable deep learning prediction of antibody viscosity using a biophysically meaningful representation von Rai, Brajesh K., Apgar, James R., Bennett, Eric M.

Volltext

AB‐Bind: Antibody binding mutational database for computational affinity predictions von Sirin, Sarah, Apgar, James R., Bennett, Eric M., Keating, Amy E.

Volltext

Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design von Apgar, James R, Tam, Amy S P, Sorm, Rhady, Moesta, Sybille, King, Amy C, Yang, Han, Kelleher, Kerry, Murphy, Denise, D'Antona, Aaron M, Yan, Guoying, Zhong, Xiaotian, Rodriguez, Linette, Ma, Weijun, Ferguson, Darren E, Carven, Gregory J, Bennett, Eric M, Lin, Laura

Volltext

Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor von Apgar, James M., Wilkening, Robert R., Parker, Dann L., Meng, Dongfang, Wildonger, Kenneth J., Sperbeck, Donald, Greenlee, Mark L., Balkovec, James M., Flattery, Amy M., Abruzzo, George K., Galgoci, Andrew M., Giacobbe, Robert A., Gill, Charles J., Hsu, Ming-Jo, Liberator, Paul, Misura, Andrew S., Motyl, Mary, Nielsen Kahn, Jennifer, Powles, Maryann, Racine, Fred, Dragovic, Jasminka, Fan, Weiming, Kirwan, Robin, Lee, Shu, Liu, Hao, Mamai, Ahmed, Nelson, Kingsley, Peel, Michael

Volltext

Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics von Avery, Lindsay B, Wade, Jason, Wang, Mengmeng, Tam, Amy, King, Amy, Piche-Nicholas, Nicole, Kavosi, Mania S, Penn, Steve, Cirelli, David, Kurz, Jeffrey C, Zhang, Minlei, Cunningham, Orla, Jones, Rhys, Fennell, Brian J, McDonnell, Barry, Sakorafas, Paul, Apgar, James, Finlay, William J, Lin, Laura, Bloom, Laird, O'Hara, Denise M

Volltext

Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody von Campbell, Sharon M, DeBartolo, Joseph, Apgar, James R, Mosyak, Lydia, McManus, Virginie, Beyer, Sonia, Bennett, Eric M, Lambert, Matthew, Cunningham, Orla

Volltext

Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody von Apgar, James R, Mader, Michelle, Agostinelli, Rita, Benard, Susan, Bialek, Peter, Johnson, Mark, Gao, Yijie, Krebs, Mark, Owens, Jane, Parris, Kevin, St Andre, Michael, Svenson, Kris, Morris, Carl, Tchistiakova, Lioudmila

Volltext

Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease von Zhong, Xiaotian, Jagarlapudi, Srinath, Weng, Yan, Ly, Mellisa, Rouse, Jason C., McClure, Kim, Ishino, Tetsuya, Zhang, Yan, Sousa, Eric, Cohen, Justin, Tzvetkova, Boriana, Cote, Kaffa, Scarcelli, John J., Johnson, Keith, Palandra, Joe, Apgar, James R., Yaddanapudi, Suma, Gonzalez-Villalobos, Romer A., Opsahl, Alan C., Lam, Khetemenee, Yao, Qing, Duan, Weili, Sievers, Annette, Zhou, Jing, Ferguson, Darren, D'Antona, Aaron, Zollner, Richard, Zhu, Hongli L., Kriz, Ron, Lin, Laura, Clerin, Valerie

Volltext

MK-5204: An orally active β-1,3-glucan synthesis inhibitor von Apgar, James M., Wilkening, Robert R., Parker, Dann L., Meng, Dongfang, Wildonger, Kenneth J., Sperbeck, Donald, Greenlee, Mark L., Balkovec, James M., Flattery, Amy M., Abruzzo, George K., Galgoci, Andrew M., Giacobbe, Robert A., Gill, Charles J., Hsu, Ming-Jo, Liberator, Paul, Misura, Andrew S., Motyl, Mary, Kahn, Jennifer Nielsen, Powles, Maryann, Racine, Fred, Dragovic, Jasminka, Fan, Weiming, Kirwan, Robin, Lee, Shu, Liu, Hao, Mamai, Ahmed, Nelson, Kingsley, Peel, Michael

Volltext

Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies von Townsend, Sue, Fennell, Brian J., Apgar, James R., Lambert, Matthew, McDonnell, Barry, Grant, Joanne, Wade, Jason, Franklin, Edward, Foy, Niall, Shúilleabháin, Deirdre Ní, Fields, Conor, Darmanin-Sheehan, Alfredo, King, Amy, Paulsen, Janet E., Hickling, Timothy P., Tchistiakova, Lioudmila, Cunningham, Orla, Finlay, William J. J.

Volltext

Modeling Backbone Flexibility to Achieve Sequence Diversity: The Design of Novel α-Helical Ligands for Bcl-xL von Fu, Xiaoran, Apgar, James R., Keating, Amy E.

Volltext

Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin von Apgar, James M., Wilkening, Robert R., Greenlee, Mark L., Balkovec, James M., Flattery, Amy M., Abruzzo, George K., Galgoci, Andrew M., Giacobbe, Robert A., Gill, Charles J., Hsu, Ming Jo, Liberator, Paul, Misura, Andrew S., Motyl, Mary, Nielsen Kahn, Jennifer, Powles, Maryann, Racine, Fred, Dragovic, Jasminka, Habulihaz, Bahanu, Fan, Weiming, Kirwan, Robin, Lee, Shu, Liu, Hao, Mamai, Ahmed, Nelson, Kingsley, Peel, Michael

Volltext

Structure–activity-relationship of amide and sulfonamide analogs of omarigliptin von Chen, Ping, Feng, Dennis, Qian, Xiaoxia, Apgar, James, Wilkening, Robert, Kuethe, Jeffrey T., Gao, Ying-Duo, Scapin, Giovanna, Cox, Jason, Doss, George, Eiermann, George, He, Huaibing, Li, Xiaohua, Lyons, Kathryn A., Metzger, Joseph, Petrov, Aleksandr, Wu, Joseph K., Xu, Shiyao, Weber, Ann E., Yan, Youwei, Roy, Ranabir Sinha, Biftu, Tesfaye

Volltext

Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase von Heasley, Brian H., Pacofsky, Gregory J., Mamai, Ahmed, Liu, Hao, Nelson, Kingsley, Coti, Ghjuvanni, Peel, Michael R., Balkovec, James M., Greenlee, Mark L., Liberator, Paul, Meng, Dongfang, Parker, Dann L., Wilkening, Robert R., Apgar, James M., Racine, F., Hsu, Ming Jo, Giacobbe, Robert A., Kahn, Jennifer Nielsen

Volltext

Predicting helix orientation for coiled-coil dimers von Apgar, James R., Gutwin, Karl N., Keating, Amy E.

Volltext

Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver von Muise, Eric S, Guan, Hong-Ping, Liu, Jinqi, Nawrocki, Andrea R, Yang, Xiaodong, Wang, Chuanlin, Rodríguez, Carlos G, Zhou, Dan, Gorski, Judith N, Kurtz, Marc M, Feng, Danqing, Leavitt, Kenneth J, Wei, Lan, Wilkening, Robert R, Apgar, James M, Xu, Shiyao, Lu, Ku, Feng, Wen, Li, Ying, He, Huaibing, Previs, Stephen F, Shen, Xiaolan, van Heek, Margaret, Souza, Sandra C, Rosenbach, Mark J, Biftu, Tesfaye, Erion, Mark D, Kelley, David E, Kemp, Daniel M, Myers, Robert W, Sebhat, Iyassu K

Volltext

Cluster expansion models for flexible-backbone protein energetics von Apgar, James R, Hahn, Seungsoo, Grigoryan, Gevorg, Keating, Amy E

Volltext

A predictive model of intein insertion site for use in the engineering of molecular switches von Apgar, James, Ross, Mary, Zuo, Xiao, Dohle, Sarah, Sturtevant, Derek, Shen, Binzhang, de la Vega, Humberto, Lessard, Philip, Lazar, Gabor, Raab, R Michael

Volltext

Engineering a thermoregulated intein-modified xylanase into maize for consolidated lignocellulosic biomass processing von Shen, Binzhang, Sun, Xueguang, Zuo, Xiao, Shilling, Taran, Apgar, James, Ross, Mary, Bougri, Oleg, Samoylov, Vladimir, Parker, Matthew, Hancock, Elaina, Lucero, Hector, Gray, Benjamin, Ekborg, Nathan A, Zhang, Dongcheng, Johnson, Jeremy C Schley, Lazar, Gabor, Raab, R Michael

Volltext

Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors von Root, Adam R, Guntas, Gurkan, Katragadda, Madan, Apgar, James R, Narula, Jatin, Chang, Chew Shun, Hanscom, Sara, McKenna, Matthew, Wade, Jason, Meade, Caryl, Ma, Weijun, Guo, Yongjing, Liu, Yan, Duan, Weili, Hendershot, Claire, King, Amy C, Zhang, Yan, Sousa, Eric, Tam, Amy, Benard, Susan, Yang, Han, Kelleher, Kerry, Jin, Fang, Piche-Nicholas, Nicole, Keating, Sinead E, Narciandi, Fernando, Lawrence-Henderson, Rosemary, Arai, Maya, Stochaj, Wayne R, Svenson, Kristine, Mosyak, Lidia, Lam, Khetemcnee, Francis, Christopher, Marquette, Kimberly, Wroblewska, Liliana, Zhu, H Lily, Sheehan, Alfredo Darmanin, LaVallie, Edward R, D'Antona, Aaron M, Betts, Alison, King, Lindsay, Rosfjord, Edward, Cunningham, Orla, Lin, Laura, Sapra, Puja, Tchistiakova, Lioudmila, Mathur, Divya, Bloom, Laird

Volltext