Metabolically Stable tert-Butyl Replacement von Barnes-Seeman, David, Jain, Monish, Bell, Leslie, Ferreira, Suzie, Cohen, Scott, Chen, Xiao-Hui, Amin, Jakal, Snodgrass, Brad, Hatsis, Panos

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Highly sensitive liquid chromatography–mass spectrometry method for the quantitative analysis of mometasone furoate in human plasma: Method validation and application to clinical p... von Heudi, Olivier, Jain, Monish, Winter, Serge

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Topical Ocular TRPV1 Antagonist SAF312 (Libvatrep) Demonstrates Safety, Low Systemic Exposure, and No Anesthetic Effect in Healthy Participants von Stasi, Kalliopi, Alshare, Qusai, Jain, Monish, Wald, Michael, Li, Yifang

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SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice von Palacino, James, Swalley, Susanne E, Song, Cheng, Cheung, Atwood K, Shu, Lei, Zhang, Xiaolu, Van Hoosear, Mailin, Shin, Youngah, Chin, Donovan N, Keller, Caroline Gubser, Beibel, Martin, Renaud, Nicole A, Smith, Thomas M, Salcius, Michael, Shi, Xiaoying, Hild, Marc, Servais, Rebecca, Jain, Monish, Deng, Lin, Bullock, Caroline, McLellan, Michael, Schuierer, Sven, Murphy, Leo, Blommers, Marcel J J, Blaustein, Cecile, Berenshteyn, Frada, Lacoste, Arnaud, Thomas, Jason R, Roma, Guglielmo, Michaud, Gregory A, Tseng, Brian S, Porter, Jeffery A, Myer, Vic E, Tallarico, John A, Hamann, Lawrence G, Curtis, Daniel, Fishman, Mark C, Dietrich, William F, Dales, Natalie A, Sivasankaran, Rajeev

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Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research von Tuntland, Tove, Ethell, Brian, Kosaka, Takatoshi, Blasco, Francesca, Zang, Richard Xu, Jain, Monish, Gould, Ty, Hoffmaster, Keith

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Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron‑2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA) von Cheung, Atwood K, Hurley, Brian, Kerrigan, Ryan, Shu, Lei, Chin, Donovan N, Shen, Yiping, O’Brien, Gary, Sung, Moo Je, Hou, Ying, Axford, Jake, Cody, Emma, Sun, Robert, Fazal, Aleem, Tomlinson, Ronald C, Jain, Monish, Deng, Lin, Hoffmaster, Keith, Song, Cheng, Van Hoosear, Mailin, Shin, Youngah, Servais, Rebecca, Towler, Christopher, Hild, Marc, Curtis, Daniel, Dietrich, William F, Hamann, Lawrence G, Briner, Karin, Chen, Karen S, Kobayashi, Dione, Sivasankaran, Rajeev, Dales, Natalie A

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Inhaled anti-TSLP antibody fragment, ecleralimab, blocks responses to allergen in mild asthma von Gauvreau, Gail M, Hohlfeld, Jens M, FitzGerald, J Mark, Boulet, Louis-Philippe, Cockcroft, Donald W, Davis, Beth E, Korn, Stephanie, Kornmann, Oliver, Leigh, Richard, Mayers, Irvin, Watz, Henrik, Grant, Sarah S, Jain, Monish, Cabanski, Maciej, Pertel, Peter E, Jones, Ieuan, Lecot, Jean R, Cao, Hui, O'Byrne, Paul M

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Use of Intramolecular 1,5-Sulfur–Oxygen and 1,5-Sulfur–Halogen Interactions in the Design of N‑Methyl-5-aryl‑N‑(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 Spl... von Axford, Jake, Sung, Moo Je, Manchester, John, Chin, Donovan, Jain, Monish, Shin, Youngah, Dix, Ina, Hamann, Lawrence G, Cheung, Atwood K, Sivasankaran, Rajeev, Briner, Karin, Dales, Natalie A, Hurley, Brian

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Corresponding doses of mometasone furoate (MF) in once-daily inhaled fixed-dose combination (FDC) of indacaterol/mometasone furoate (IND/MF) and indacaterol/glycopyrronium/mometaso... von Buhl, Roland, Kerstjens, Huib, Nikolaev, Ivan, Vaidya, Soniya, Bartels, Christian, Jain, Monish, Jauernig, Juergen, Kottakis, Ioannis, Qian, Chenyu, Tillman, Hanns-Christian

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Small-molecule WNK inhibition regulates cardiovascular and renal function von Yamada, Ken, Park, Hyi-Man, Rigel, Dean F, DiPetrillo, Keith, Whalen, Erin J, Anisowicz, Anthony, Beil, Michael, Berstler, James, Brocklehurst, Cara Emily, Burdick, Debra A, Caplan, Shari L, Capparelli, Michael P, Chen, Guanjing, Chen, Wei, Dale, Bethany, Deng, Lin, Fu, Fumin, Hamamatsu, Norio, Harasaki, Kouki, Herr, Tracey, Hoffmann, Peter, Hu, Qi-Ying, Huang, Waan-Jeng, Idamakanti, Neeraja, Imase, Hidetomo, Iwaki, Yuki, Jain, Monish, Jeyaseelan, Jey, Kato, Mitsunori, Kaushik, Virendar K, Kohls, Darcy, Kunjathoor, Vidya, LaSala, Daniel, Lee, Jongchan, Liu, Jing, Luo, Yang, Ma, Fupeng, Mo, Ruowei, Mowbray, Sarah, Mogi, Muneto, Ossola, Flavio, Pandey, Pramod, Patel, Sejal J, Raghavan, Swetha, Salem, Bahaa, Shanado, Yuka H, Trakshel, Gary M, Turner, Gordon, Wakai, Hiromichi, Wang, Chunhua, Weldon, Stephen, Wielicki, Jennifer B, Xie, Xiaoling, Xu, Lingfei, Yagi, Yukiko I, Yasoshima, Kayo, Yin, Jianning, Yowe, David, Zhang, Ji-Hu, Zheng, Gang, Monovich, Lauren

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Population Pharmacokinetic Analysis of Indacaterol/Glycopyrronium/Mometasone Furoate After Administration of Combination Therapies Using the Breezhaler® Device in Patients with Ast... von Bartels, Christian, Jain, Monish, Yu, Jing, Tillmann, Hanns-Christian, Vaidya, Soniya

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Corrigendum to “Dose bridging data for mometasone furoate in once-daily fixed-dose inhaled combinations of mometasone furoate/indacaterol and mometasone furoate/indacaterol/glycopy... von Buhl, Roland, Nikolaev, Ivan, Tillmann, Hanns-Christian, Vaidya, Soniya, Bartels, Christian, Jain, Monish, Jauernig, Juergen, Kerstjens, Huib A.M.

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Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models von Yamada, Ken, Levell, Julian, Yoon, Taeyong, Kohls, Darcy, Yowe, David, Rigel, Dean F, Imase, Hidetomo, Yuan, Jun, Yasoshima, Kayo, DiPetrillo, Keith, Monovich, Lauren, Xu, Lingfei, Zhu, Meicheng, Kato, Mitsunori, Jain, Monish, Idamakanti, Neeraja, Taslimi, Paul, Kawanami, Toshio, Argikar, Upendra A, Kunjathoor, Vidya, Xie, Xiaoling, Yagi, Yukiko I, Iwaki, Yuki, Robinson, Zachary, Park, Hyi-Man

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Efficacy, Safety, and Systemic Exposure of Once-Daily Indacaterol Acetate in Pediatric Asthma: A Randomized, Double-Blind, Controlled Dose-Finding Study von Sekerel, Bulent Enis, Nell, Haylene, Laki, Istvan, Pak, Tatiana, Contreras, Edgar, Kolarz, Adam, D’Andrea, Peter, Manga, Volkan, Jain, Monish, Vaidya, Soniya, Valentin, Michele, Sen, Biswajit

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Dose bridging data for mometasone furoate in once-daily fixed-dose inhaled combinations of mometasone furoate/indacaterol and mometasone furoate/ indacaterol/glycopyrronium in pati... von Buhl, Roland, Nikolaev, Ivan, Tillmann, Hanns-Christian, Vaidya, Soniya, Bartels, Christian, Jain, Monish, Jauernig, Juergen, Kerstjens, Huib A.M.

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Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins von Ziegler, David S, Wright, Renee D, Kesari, Santosh, Lemieux, Madeleine E, Tran, Mary A, Jain, Monish, Zawel, Leigh, Kung, Andrew L

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Discovery of an Orally Bioavailable Benzimidazole Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitor That Suppresses Body Weight Gain in Diet-Induced Obese Dogs and Postprandial Tr... von Nakajima, Katsumasa, Chatelain, Ricardo, Clairmont, Kevin B, Commerford, Renee, Coppola, Gary M, Daniels, Thomas, Forster, Cornelia J, Gilmore, Thomas A, Gong, Yongjin, Jain, Monish, Kanter, Aaron, Kwak, Youngshin, Li, Jingzhou, Meyers, Charles D, Neubert, Alan D, Szklennik, Paul, Tedesco, Vivienne, Thompson, James, Truong, David, Yang, Qing, Hubbard, Brian K, Serrano-Wu, Michael H

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Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors von Nakajima, Katsumasa, April, Myriam, Brewer, Jason T., Daniels, Thomas, Forster, Cornelia J., Gilmore, Thomas A., Jain, Monish, Kanter, Aaron, Kwak, Youngshin, Li, Jingzhou, McQuire, Les, Serrano-Wu, Michael H., Streeper, Ryan, Szklennik, Paul, Thompson, James, Wang, Bing

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Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice von Palacino, James, Swalley, Susanne E, Song, Cheng, Cheung, Atwood K, Shu, Lei, Zhang, Xiaolu, Van Hoosear, Mailin, Shin, Youngah, Chin, Donovan N, Keller, Caroline Gubser, Beibel, Martin, Renaud, Nicole A, Smith, Thomas M, Salcius, Michael, Shi, Xiaoying, Hild, Marc, Servais, Rebecca, Jain, Monish, Deng, Lin, Bullock, Caroline, McLellan, Michael, Schuierer, Sven, Murphy, Leo, Blommers, Marcel J J, Blaustein, Cecile, Berenshteyn, Frada, Lacoste, Arnaud, Thomas, Jason R, Roma, Guglielmo, Michaud, Gregory A, Tseng, Brian S, Porter, Jeffery A, Myer, Vic E, Tallarico, John A, Hamann, Lawrence G, Curtis, Daniel, Fishman, Mark C, Dietrich, William F, Dales, Natalie A, Sivasankaran, Rajeev

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Erratum: Corrigendum: SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice von Palacino, James, Swalley, Susanne E, Song, Cheng, Cheung, Atwood K, Shu, Lei, Zhang, Xiaolu, Van Hoosear, Mailin, Shin, Youngah, Chin, Donovan N, Keller, Caroline Gubser, Beibel, Martin, Renaud, Nicole A, Smith, Thomas M, Salcius, Michael, Shi, Xiaoying, Hild, Marc, Servais, Rebecca, Jain, Monish, Deng, Lin, Bullock, Caroline, McLellan, Michael, Schuierer, Sven, Murphy, Leo, Blommers, Marcel J J, Blaustein, Cecile, Berenshteyn, Frada, Lacoste, Arnaud, Thomas, Jason R, Roma, Guglielmo, Michaud, Gregory A, Tseng, Brian S, Porter, Jeffery A, Myer, Vic E, Tallarico, John A, Hamann, Lawrence G, Curtis, Daniel, Fishman, Mark C, Dietrich, William F, Dales, Natalie A, Sivasankaran, Rajeev

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