Site-specific antibody drug conjugates for cancer therapy von Panowski, Siler, Bhakta, Sunil, Raab, Helga, Polakis, Paul, Junutula, Jagath R

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Exploration of the antibody-drug conjugate clinical landscape von Maecker, Heather, Jonnalagadda, Vidya, Bhakta, Sunil, Jammalamadaka, Vasu, Junutula, Jagath R.

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Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates von Shen, Ben-Quan, Xu, Keyang, Liu, Luna, Raab, Helga, Bhakta, Sunil, Kenrick, Margaret, Parsons-Reponte, Kathryn L, Tien, Janet, Yu, Shang-Fan, Mai, Elaine, Li, Dongwei, Tibbitts, Jay, Baudys, Jakub, Saad, Ola M, Scales, Suzie J, McDonald, Paul J, Hass, Philip E, Eigenbrot, Charles, Nguyen, Trung, Solis, Willy A, Fuji, Reina N, Flagella, Kelly M, Patel, Darshana, Spencer, Susan D, Khawli, Leslie A, Ebens, Allen, Wong, Wai Lee, Vandlen, Richard, Kaur, Surinder, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R

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High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers von Ohri, Rachana, Bhakta, Sunil, Fourie-O’Donohue, Aimee, dela Cruz-Chuh, Josefa, Tsai, Siao Ping, Cook, Ryan, Wei, Binqing, Ng, Carl, Wong, Athena W, Bos, Aaron B, Farahi, Farzam, Bhakta, Jiten, Pillow, Thomas H, Raab, Helga, Vandlen, Richard, Polakis, Paul, Liu, Yichin, Erickson, Hans, Junutula, Jagath R, Kozak, Katherine R

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Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2 von Suryamohan, Kushal, Diwanji, Devan, Stawiski, Eric W., Gupta, Ravi, Miersch, Shane, Liu, Jiang, Chen, Chao, Jiang, Ying-Ping, Fellouse, Frederic A., Sathirapongsasuti, J. Fah, Albers, Patrick K., Deepak, Tanneeru, Saberianfar, Reza, Ratan, Aakrosh, Washburn, Gavin, Mis, Monika, Santhosh, Devi, Somasekar, Sneha, Hiranjith, G. H., Vargas, Derek, Mohan, Sangeetha, Phalke, Sameer, Kuriakose, Boney, Antony, Aju, Ustav Jr, Mart, Schuster, Stephan C., Sidhu, Sachdev, Junutula, Jagath R., Jura, Natalia, Seshagiri, Somasekar

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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index von Junutula, Jagath R, Mallet, William, Raab, Helga, Clark, Suzanna, Bhakta, Sunil, Leipold, Douglas D, Weir, Sylvia, Chen, Yvonne, Simpson, Michelle, Tsai, Siao Ping, Dennis, Mark S, Lu, Yanmei, Meng, Y Gloria, Ng, Carl, Yang, Jihong, Lee, Chien C, Duenas, Eileen, Gorrell, Jeffrey, Katta, Viswanatham, Kim, Amy, McDorman, Kevin, Flagella, Kelly, Venook, Rayna, Ross, Sarajane, Spencer, Susan D, Lee Wong, Wai, Lowman, Henry B, Vandlen, Richard, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul

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Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry von Xu, Keyang, Liu, Luna, Saad, Ola M., Baudys, Jakub, Williams, Lara, Leipold, Douglas, Shen, Ben, Raab, Helga, Junutula, Jagath R., Kim, Amy, Kaur, Surinder

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Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma von Dornan, David, Bennett, Fiona, Chen, Yvonne, Dennis, Mark, Eaton, Dan, Elkins, Kristi, French, Dorothy, Go, Mary Ann T., Jack, Andrew, Junutula, Jagath R., Koeppen, Hartmut, Lau, Jeffrey, McBride, Jacqueline, Rawstron, Andy, Shi, Xiaoyan, Yu, Nancy, Yu, Shang-Fan, Yue, Peng, Zheng, Bing, Ebens, Allen, Polson, Andrew G.

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Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice von Hocking, Samantha L., Stewart, Rebecca L., Brandon, Amanda E., Suryana, Eurwin, Stuart, Ella, Baldwin, Emily M., Kolumam, Ganesh A., Modrusan, Zora, Junutula, Jagath R., Gunton, Jenny E., Medynskyj, Michael, Blaber, Sinead P., Karsten, Elisabeth, Herbert, Benjamin R., James, David E., Cooney, Gregory J., Swarbrick, Michael M.

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Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway von Trefely, Sophie, Khoo, Poh-Sim, Krycer, James R., Chaudhuri, Rima, Fazakerley, Daniel J., Parker, Benjamin L., Sultani, Ghazal, Lee, James, Stephan, Jean-Philippe, Torres, Eric, Jung, Kenneth, Kuijl, Coenraad, James, David E., Junutula, Jagath R., Stöckli, Jacqueline

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Characterization of the Role of the Rab GTPase-activating Protein AS160 in Insulin-regulated GLUT4 Trafficking von Larance, Mark, Ramm, Georg, Stöckli, Jacqueline, van Dam, Ellen M., Winata, Stephanie, Wasinger, Valerie, Simpson, Fiona, Graham, Michael, Junutula, Jagath R., Guilhaus, Michael, James, David E.

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Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes von Tan, Shi-Xiong, Ng, Yvonne, Meoli, Christopher C., Kumar, Ansu, Khoo, Poh-Sim, Fazakerley, Daniel J., Junutula, Jagath R., Vali, Shireen, James, David E., Stöckli, Jacqueline

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An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer von Bhakta, Sunil, Crocker, Lisa M, Chen, Yvonne, Hazen, Meredith, Schutten, Melissa M, Li, Dongwei, Kuijl, Coenraad, Ohri, Rachana, Zhong, Fiona, Poon, Kirsten A, Go, Mary Ann T, Cheng, Eric, Piskol, Robert, Firestein, Ron, Fourie-O'Donohue, Aimee, Kozak, Katherine R, Raab, Helga, Hongo, Jo-Anne, Sampath, Deepak, Dennis, Mark S, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R

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Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs von Junutula, Jagath R., Bhakta, Sunil, Raab, Helga, Ervin, Karen E., Eigenbrot, Charles, Vandlen, Richard, Scheller, Richard H., Lowman, Henry B.

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CLT030, a leukemic stem cell–targeting CLL1 antibody-drug conjugate for treatment of acute myeloid leukemia von Jiang, Ying-Ping, Liu, Bob Y., Zheng, Quan, Panuganti, Swapna, Chen, Ruoying, Zhu, Jianyu, Mishra, Madhavi, Huang, Jianqing, Dao-Pick, Trang, Roy, Sharmili, Zhao, XiaoXian, Lin, Jeffrey, Banik, Gautam, Hsi, Eric D., Mandalam, Ramkumar, Junutula, Jagath R.

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Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria von Kuijl, Coenraad, Pilli, Manohar, Alahari, Suresh K, Janssen, Hans, Khoo, Poh-Sim, Ervin, Karen E, Calero, Monica, Jonnalagadda, Sobhanaditya, Scheller, Richard H, Neefjes, Jacques, Junutula, Jagath R

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Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase von Jin, Rongsheng, Junutula, Jagath R, Matern, Hugo T, Ervin, Karen E, Scheller, Richard H, Brunger, Axel T

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Rab14 is involved in membrane trafficking between the Golgi complex and endosomes von Junutula, Jagath R, De Maziére, Ann M, Peden, Andrew A, Ervin, Karen E, Advani, Raj J, van Dijk, Suzanne M, Klumperman, Judith, Scheller, Richard H

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Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells von Jacob, Abitha, Jing, Jian, Lee, James, Schedin, Pepper, Gilbert, Simon M, Peden, Andrew A, Junutula, Jagath R, Prekeris, Rytis

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Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene von Westlake, Christopher J, Junutula, Jagath R, Simon, Glenn C, Pilli, Manohar, Prekeris, Rytis, Scheller, Richard H, Jackson, Peter K, Eldridge, Adam G

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