2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studies toward the Discovery of N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piper... von Das, Jagabandhu, Chen, Ping, Norris, Derek, Padmanabha, Ramesh, Lin, James, Moquin, Robert V, Shen, Zhongqi, Cook, Lynda S, Doweyko, Arthur M, Pitt, Sidney, Pang, Suhong, Shen, Ding Ren, Fang, Qiong, de Fex, Henry F, McIntyre, Kim W, Shuster, David J, Gillooly, Kathleen M, Behnia, Kamelia, Schieven, Gary L, Wityak, John, Barrish, Joel C

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Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors von Das, Jagabandhu, Liu, Chunjian, Moquin, Robert V., Lin, James, Furch, Joseph A., Spergel, Steven H., McIntyre, Kim W., Shuster, David J., O’Day, Kathleen D., Penhallow, Becky, Hung, Chen-Yi, Kanner, Steven B., Lin, Tai-An, Dodd, John H., Barrish, Joel C., Wityak, John

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Discovery of N-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibit... von Lombardo, Louis J, Lee, Francis Y, Chen, Ping, Norris, Derek, Barrish, Joel C, Behnia, Kamelia, Castaneda, Stephen, Cornelius, Lyndon A. M, Das, Jagabandhu, Doweyko, Arthur M, Fairchild, Craig, Hunt, John T, Inigo, Ivan, Johnston, Kathy, Kamath, Amrita, Kan, David, Klei, Herbert, Marathe, Punit, Pang, Suhong, Peterson, Russell, Pitt, Sidney, Schieven, Gary L, Schmidt, Robert J, Tokarski, John, Wen, Mei-Li, Wityak, John, Borzilleri, Robert M

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Discovery of highly potent, selective, covalent inhibitors of JAK3 von Kempson, James, Ovalle, Damaso, Guo, Junqing, Wrobleski, Stephen T., Lin, Shuqun, Spergel, Steven H., Duan, James J.-W., Jiang, Bin, Lu, Zhonghui, Das, Jagabandhu, Yang, Bingwei V., Hynes, John, Wu, Hong, Tokarski, John, Sack, John S., Khan, Javed, Schieven, Gary, Blatt, Yuval, Chaudhry, Charu, Salter-Cid, Luisa M., Fura, Aberra, Barrish, Joel C., Carter, Percy H., Pitts, William J.

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Molecular design, synthesis, and structure-activity relationships leading to the potent and selective p56lck inhibitor BMS-243117 von DAS, Jagabandhu, LIN, James, PITT, Sidney, DING REN SHEN, SCHIEVEN, Gary L, BARRISH, Joel C, MOQUIN, Robert V, ZHONGQI SHEN, SPERGEL, Steven H, WITYAK, John, DOWEYKO, Arthur M, DEFEX, Henry F, QIONG FANG, SUHONG PANG

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Pyrazolo-pyrimidines: A novel heterocyclic scaffold for potent and selective p38α inhibitors von Das, Jagabandhu, Moquin, Robert V., Pitt, Sidney, Zhang, Rosemary, Shen, Ding Ren, McIntyre, Kim W., Gillooly, Kathleen, Doweyko, Arthur M., Sack, John S., Zhang, Hongjian, Kiefer, Susan E., Kish, Kevin, McKinnon, Murray, Barrish, Joel C., Dodd, John H., Schieven, Gary L., Leftheris, Katerina

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5-Amino-pyrazoles as potent and selective p38α inhibitors von Das, Jagabandhu, Moquin, Robert V., Dyckman, Alaric J., Li, Tianle, Pitt, Sidney, Zhang, Rosemary, Shen, Ding Ren, McIntyre, Kim W., Gillooly, Kathleen, Doweyko, Arthur M., Newitt, John A., Sack, John S., Zhang, Hongjian, Kiefer, Susan E., Kish, Kevin, McKinnon, Murray, Barrish, Joel C., Dodd, John H., Schieven, Gary L., Leftheris, Katerina

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Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56(lck) inhibitors von Das, Jagabandhu, Moquin, Robert V, Lin, James, Liu, Chunjian, Doweyko, Arthur M, DeFex, Henry F, Fang, Qiong, Pang, Suhong, Pitt, Sidney, Shen, Ding Ren, Schieven, Gary L, Barrish, Joel C, Wityak, John

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Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation von Lin, Tai-An, McIntyre, Kim W, Das, Jagabandhu, Liu, Chunjian, O'Day, Kathleen D, Penhallow, Becky, Hung, Chen-Yi, Whitney, Gena S, Shuster, David J, Yang, XiaoXia, Townsend, Robert, Postelnek, Jennifer, Spergel, Steven H, Lin, James, Moquin, Robert V, Furch, Joseph A, Kamath, Amrita V, Zhang, Hongjian, Marathe, Punit H, Perez-Villar, Juan J, Doweyko, Arthur, Killar, Loran, Dodd, John H, Barrish, Joel C, Wityak, John, Kanner, Steven B

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Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors von Das, Jagabandhu, Furch, Joseph A., Liu, Chunjian, Moquin, Robert V., Lin, James, Spergel, Steven H., McIntyre, Kim W., Shuster, David J., O’Day, Kathleen D., Penhallow, Becky, Hung, Chen-Yi, Doweyko, Arthur M., Kamath, Amrita, Zhang, Hongjian, Marathe, Punit, Kanner, Steven B., Lin, Tai-An, Dodd, John H., Barrish, Joel C., Wityak, John

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Novel Tricyclic Inhibitors of IκB Kinase von Kempson, James, Spergel, Steven H, Guo, Junqing, Quesnelle, Claude, Gill, Patrice, Belanger, Dominique, Dyckman, Alaric J, Li, Tianle, Watterson, Scott H, Langevine, Charles M, Das, Jagabandhu, Moquin, Robert V, Furch, Joseph A, Marinier, Anne, Dodier, Marco, Martel, Alain, Nirschl, David, Van Kirk, Katy, Burke, James R, Pattoli, Mark A, Gillooly, Kathleen, McIntyre, Kim W, Chen, Laishun, Yang, Zheng, Marathe, Punit H, Wang-Iverson, David, Dodd, John H, McKinnon, Murray, Barrish, Joel C, Pitts, William J

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Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy- N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-7... von Watterson, Scott H., Langevine, Charles M., Van Kirk, Katy, Kempson, James, Guo, Junquing, Spergel, Steven H., Das, Jagabandhu, Moquin, Robert V., Dyckman, Alaric J., Nirschl, David, Gregor, Kurt, Pattoli, Mark A., Yang, XiaoXia, McIntyre, Kim W., Yang, Guchen, Galella, Michael A., Booth-Lute, Hollie, Chen, Laishun, Yang, Zheng, Wang-Iverson, David, McKinnon, Murray, Dodd, John H., Barrish, Joel C., Burke, James R., Pitts, William J.

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Novel methods for syntheses of substituted oxazoles by cyclization of vinyl bromides von Das, Jagabandhu, Reid, Joyce A., Kronenthal, David R., Singh, Janak, Pansegrau, Paul D., Mueller, Richard H.

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Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5- d]pyrrolo[2,3- b]pyridin-4-amine derived inhibitors of IκB kinase von Kempson, James, Guo, Junqing, Das, Jagabandhu, Moquin, Robert V., Spergel, Steven H., Watterson, Scott H., Langevine, Charles M., Dyckman, Alaric J., Pattoli, Mark, Burke, James R., Yang, XiaoXia, Gillooly, Kathleen M., McIntyre, Kim W., Chen, Laishun, Dodd, John H., McKinnon, Murray, Barrish, Joel C., Pitts, William J.

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Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy-N-6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)p... von WATTERSON, Scott H, LANGEVINE, Charles M, GREGOR, Kurt, PATTOLI, Mark A, XIAOXIA YANG, MCINTYRE, Kim W, GUCHEN YANG, GALELLA, Michael A, BOOTH-LUTE, Hollie, LAISHUN CHEN, ZHENG YANG, WANG-IVERSON, David, KIRK, Katy Van, MCKINNON, Murray, DODD, John H, BARRISH, Joel C, BURKE, James R, PITTS, William J, KEMPSON, James, JUNQUING GUO, SPERGEL, Steven H, DAS, Jagabandhu, MOQUIN, Robert V, DYCKMAN, Alaric J, NIRSCHL, David

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5-Amino-pyrazoles as potent and selective p38a inhibitors von Das, Jagabandhu, Moquin, Robert V, Dyckman, Alaric J, Li, Tianle, Pitt, Sidney, Zhang, Rosemary, Shen, Ding Ren, McIntyre, Kim W, Gillooly, Kathleen, Doweyko, Arthur M, Newitt, John A, Sack, John S, Zhang, Hongjian, Kiefer, Susan E, Kish, Kevin, McKinnon, Murray, Barrish, Joel C, Dodd, John H, Schieven, Gary L, Leftheris, Katerina

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Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117 von Das, Jagabandhu, Lin, James, Moquin, Robert V, Shen, Zhongqi, Spergel, Steven H, Wityak, John, Doweyko, Arthur M, DeFex, Henry F, Fang, Qiong, Pang, Suhong, Pitt, Sidney, Shen, Ding Ren, Schieven, Gary L, Barrish, Joel C

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Thrombin active site inhibitors von Das, Jagabandhu, David Kimball, S.

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Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56(Lck) von Wityak, John, Das, Jagabandhu, Moquin, Robert V, Shen, Zhongqi, Lin, James, Chen, Ping, Doweyko, Arthur M, Pitt, Sidney, Pang, Suhong, Shen, Ding Ren, Fang, Qiong, de Fex, Henry F, Schieven, Gary L, Kanner, Steven B, Barrish, Joel C

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Inibidores de tirosina quinase de proteína cíclica von Chen Ping, Wityak John, Joel C. Barrish, Arthur M. P. Doweyko, Padmanabha Ramesh, Das Jagabandhu, Derek J. Norris

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