News from DMCCB - Targeted Protein Degradation von Jaeschke, Georg

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Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion von Tian, Di, Stoppel, Laura J, Heynen, Arnold J, Lindemann, Lothar, Jaeschke, Georg, Mills, Alea A, Bear, Mark F

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Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers von Heinig, Katja, Sladojevich, Filippo, Petrig Schaffland, Jeannine, Jaeschke, Georg, Ross, Alfred, Koldewey, Philipp, Miladinović, Saša M., Wang, Jin, Rynn, Caroline

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mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex von Kelly, Elyza, Schaeffer, Samantha M, Dhamne, Sameer C, Lipton, Jonathan O, Lindemann, Lothar, Honer, Michael, Jaeschke, Georg, Super, Chloe E, Lammers, Stephen Ht, Modi, Meera E, Silverman, Jill L, Dreier, John R, Kwiatkowski, David J, Rotenberg, Alexander, Sahin, Mustafa

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Chronic Metabotropic Glutamate Receptor 5 Inhibition Corrects Local Alterations of Brain Activity and Improves Cognitive Performance in Fragile X Mice von Michalon, Aubin, Bruns, Andreas, Risterucci, Céline, Honer, Michael, Ballard, Theresa M, Ozmen, Laurence, Jaeschke, Georg, Wettstein, Joseph G, von Kienlin, Markus, Künnecke, Basil, Lindemann, Lothar

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Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities von Morgenthaler, Martin, Schweizer, Eliane, Hoffmann-Röder, Anja, Benini, Fausta, Martin, Rainer E., Jaeschke, Georg, Wagner, Björn, Fischer, Holger, Bendels, Stefanie, Zimmerli, Daniel, Schneider, Josef, Diederich, François, Kansy, Manfred, Müller, Klaus

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CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor von Lindemann, Lothar, Jaeschke, Georg, Michalon, Aubin, Vieira, Eric, Honer, Michael, Spooren, Will, Porter, Richard, Hartung, Thomas, Kolczewski, Sabine, Büttelmann, Bernd, Flament, Christophe, Diener, Catherine, Fischer, Christophe, Gatti, Silvia, Prinssen, Eric P, Parrott, Neil, Hoffmann, Gerhard, Wettstein, Joseph G

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Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2‑Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl‑1H‑imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523... von Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Büttelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk, Christoph, Guba, Wolfgang, Harrison, Anthony, Hartung, Thomas, Honer, Michael, Huwyler, Jörg, Kuratli, Martin, Niederhauser, Urs, Pähler, Axel, Peters, Jens-Uwe, Petersen, Ann, Prinssen, Eric, Ricci, Antonio, Rueher, Daniel, Rueher, Marianne, Schneider, Manfred, Spurr, Paul, Stoll, Theodor, Tännler, Daniel, Wichmann, Jürgen, Porter, Richard H, Wettstein, Joseph G, Lindemann, Lothar

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News from DMCCB – Targeted Protein Degradation: Medicinal Chemistry and Chemical Biology Highlights von Jaeschke, Georg

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Enantioselective total synthesis of callipeltoside A: two approaches to the macrolactone fragment von Evans, David A., Burch, Jason D., Hu, Essa, Jaeschke, Georg

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Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of... von Malherbe, Pari, Kratochwil, Nicole, Mühlemann, Andreas, Zenner, Marie‐Thérèse, Fischer, Christophe, Stahl, Martin, Gerber, Paul R., Jaeschke, Georg, Porter, Richard H. P.

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Enantioselective Total Synthesis of Callipeltoside A von Evans, David A, Hu, Essa, Burch, Jason D, Jaeschke, Georg

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Determination of key amino acids implicated in the actions of allosteric modulation by 3,3′-difluorobenzaldazine on rat mGlu5 receptors von Mühlemann, Andreas, Ward, Natalie A., Kratochwil, Nicole, Diener, Catherine, Fischer, Christophe, Stucki, Andy, Jaeschke, Georg, Malherbe, Pari, Porter, Richard H.P.

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Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome von Scharf, Sebastian H, Jaeschke, Georg, Wettstein, Joseph G, Lindemann, Lothar

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Differential effects of diazepam and MPEP on habituation and neuro-behavioural processes in inbred mice von Salomons, Amber R, Pinzon, Nathaly Espitia, Boleij, Hetty, Kirchhoff, Susanne, Arndt, Saskia S, Nordquist, Rebecca E, Lindemann, Lothar, Jaeschke, Georg, Spooren, Will, Ohl, Frauke

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Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice von Michalon, Aubin, Sidorov, Michael, Ballard, Theresa M., Ozmen, Laurence, Spooren, Will, Wettstein, Joseph G., Jaeschke, Georg, Bear, Mark F., Lindemann, Lothar

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News from the DMCCB - Congress Report from the Virtual EFMC-ISMC 2021: Medicinal Chemistry & Chemical Biology Highlights von Auberson, Yves P., Benfatti, Fides, Jaeschke, Georg, Zumbrunn, Cornelia

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News from the DMCCB - Congress Report from the Virtual EFMC-ISMC 2021 von Auberson, Yves P., Benfatti, Fides, Jaeschke, Georg, Zumbrunn, Cornelia

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Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression von Lindemann, Lothar, Porter, Richard H, Scharf, Sebastian H, Kuennecke, Basil, Bruns, Andreas, von Kienlin, Markus, Harrison, Anthony C, Paehler, Axel, Funk, Christoph, Gloge, Andreas, Schneider, Manfred, Parrott, Neil J, Polonchuk, Liudmila, Niederhauser, Urs, Morairty, Stephen R, Kilduff, Thomas S, Vieira, Eric, Kolczewski, Sabine, Wichmann, Juergen, Hartung, Thomas, Honer, Michael, Borroni, Edilio, Moreau, Jean-Luc, Prinssen, Eric, Spooren, Will, Wettstein, Joseph G, Jaeschke, Georg

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Resolution of racemic carboxylic acid derivatives by Ti-TADDOLate mediated esterification reactions—A general method for the preparation of enantiopure compounds von Seebach, Dieter, Jaeschke, Georg, Gottwald, Konstanze, Matsuda, Keiji, Formisano, Roberto, Chaplin, David A, Breuning, Matthias, Bringmann, Gerhard

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