News from DMCCB - Targeted Protein Degradation von Jaeschke, Georg

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Chemical, Analytical and Pharmacokinetic Characterisation of RO7304898, an API Consisting of Two Rapidly Interconverting Diastereoisomers von Heinig, Katja, Sladojevich, Filippo, Petrig Schaffland, Jeannine, Jaeschke, Georg, Ross, Alfred, Koldewey, Philipp, Miladinović, Saša M., Wang, Jin, Rynn, Caroline

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mGluR5 Modulation of Behavioral and Epileptic Phenotypes in a Mouse Model of Tuberous Sclerosis Complex von Kelly, Elyza, Schaeffer, Samantha M, Dhamne, Sameer C, Lipton, Jonathan O, Lindemann, Lothar, Honer, Michael, Jaeschke, Georg, Super, Chloe E, Lammers, Stephen Ht, Modi, Meera E, Silverman, Jill L, Dreier, John R, Kwiatkowski, David J, Rotenberg, Alexander, Sahin, Mustafa

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Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities von Morgenthaler, Martin, Schweizer, Eliane, Hoffmann-Röder, Anja, Benini, Fausta, Martin, Rainer E., Jaeschke, Georg, Wagner, Björn, Fischer, Holger, Bendels, Stefanie, Zimmerli, Daniel, Schneider, Josef, Diederich, François, Kansy, Manfred, Müller, Klaus

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CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor von Lindemann, Lothar, Jaeschke, Georg, Michalon, Aubin, Vieira, Eric, Honer, Michael, Spooren, Will, Porter, Richard, Hartung, Thomas, Kolczewski, Sabine, Büttelmann, Bernd, Flament, Christophe, Diener, Catherine, Fischer, Christophe, Gatti, Silvia, Prinssen, Eric P, Parrott, Neil, Hoffmann, Gerhard, Wettstein, Joseph G

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News from DMCCB – Targeted Protein Degradation: Medicinal Chemistry and Chemical Biology Highlights von Jaeschke, Georg

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Enantioselective total synthesis of callipeltoside A: two approaches to the macrolactone fragment von Evans, David A., Burch, Jason D., Hu, Essa, Jaeschke, Georg

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Determination of key amino acids implicated in the actions of allosteric modulation by 3,3′-difluorobenzaldazine on rat mGlu5 receptors von Mühlemann, Andreas, Ward, Natalie A., Kratochwil, Nicole, Diener, Catherine, Fischer, Christophe, Stucki, Andy, Jaeschke, Georg, Malherbe, Pari, Porter, Richard H.P.

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Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome von Scharf, Sebastian H, Jaeschke, Georg, Wettstein, Joseph G, Lindemann, Lothar

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Differential effects of diazepam and MPEP on habituation and neuro-behavioural processes in inbred mice von Salomons, Amber R, Pinzon, Nathaly Espitia, Boleij, Hetty, Kirchhoff, Susanne, Arndt, Saskia S, Nordquist, Rebecca E, Lindemann, Lothar, Jaeschke, Georg, Spooren, Will, Ohl, Frauke

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Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice von Michalon, Aubin, Sidorov, Michael, Ballard, Theresa M., Ozmen, Laurence, Spooren, Will, Wettstein, Joseph G., Jaeschke, Georg, Bear, Mark F., Lindemann, Lothar

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Novel Macrocyclic NLRP3 Inhibitors von Mesch, Stefanie, Shannon, Jonathan, Miller, David, MacLeod, Angus, Bouché, Léa, Johnston, Heather J, Matthews, Kim, Paehler, Axel, Best, Stuart, Guba, Wolfgang, Alanine, Thomas, Halai, Reena, Charge, Lorna, Garside, Samantha, Thom, Stephen, Incerti-Pradillos, Celia, McPherson, Christopher, Carrillo, Jokin, St-Gallay, Steve, Rigo, Pierre, Schlicht, Sonja, Hendrick, Alan G, Lerner, Christian, Piali, Luca, Blaising, Julie, Mracsko, Eva Z, Jaeschke, Georg, Cooper, Matthew A

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Results and evaluation of a first‐in‐human study of RG7342, an mGlu5 positive allosteric modulator, utilizing Bayesian adaptive methods von Sturm, Stefan, Delporte, Marie‐Laure, Hadi, Salah, Schobel, Scott, Lindemann, Lothar, Weikert, Robert, Jaeschke, Georg, Derks, Michael, Palermo, Giuseppe

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Contribution of mGluR5 to hippocampal pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion von Tian, Di, Stoppel, Laura J., Heynen, Arnold J., Lindemann, Lothar, Jaeschke, Georg, Mills, Alea A., Bear, Mark F.

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Stress-induced hyperthermia: Effects of acute and repeated dosing of MPEP von Nordquist, Rebecca E., Durkin, Sean, Jaeschke, Georg, Spooren, Will

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Rational design, synthesis, and structure–activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure von Ceccarelli, Simona M., Jaeschke, Georg, Buettelmann, Bernd, Huwyler, Jörg, Kolczewski, Sabine, Peters, Jens-Uwe, Prinssen, Eric, Porter, Richard, Spooren, Will, Vieira, Eric

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Disputatio inauguralis medica De mensium insolitis viis / quam rectore ... dn. Frederico Wilhelmo ... sub praesidio dn. Georgii Ernesti Stahl ... pro doctoris gradu ...ad diem Sept... von Jaeschke, Georg Friedrich

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Disputatio inauguralis medica De mensium insolitis viis / quam rectore ... dn. Frederico Wilhelmo ... sub praesidio dn. Georgii Ernesti Stahl ... pro doctoris gradu ...ad diem Sept... von Jaeschke, Georg Friedrich

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Substituted imidazo[1,2-a]imidazoles as modulators of metabotropic glutamate receptor 4 activity von O'Hara, Fionn, Vieira, Eric, Jaeschke, Georg

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Metabolite Identification via LC-SPE-NMR-MS of the In vitro Biooxidation Products of a Lead mGlu5 Allosteric Antagonist and Impact on the Improvement of Metabolic Stability in the... von Ceccarelli, Simona M., Schlotterbeck, Götz, Boissin, Patrick, Binder, Martin, Buettelmann, Bernd, Hanlon, Steven, Jaeschke, Georg, Kolczewski, Sabine, Kupfer, Ernst, Peters, Jens-Uwe, Porter, Richard H. P., Prinssen, Eric P., Rueher, Marianne, Ruf, Iris, Spooren, Will, Stämpfli, Andreas, Vieira, Eric

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