Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS von Park, Yong Hwan, Wood, Geryl, Kastner, Daniel L, Chae, Jae Jin

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The Pyrin Inflammasome in Health and Disease von Schnappauf, Oskar, Chae, Jae Jin, Kastner, Daniel L, Aksentijevich, Ivona

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The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP von Lee, Geun-Shik, Subramanian, Naeha, Kim, Andrew I., Aksentijevich, Ivona, Goldbach-Mansky, Raphaela, Sacks, David B., Germain, Ronald N., Kastner, Daniel L., Chae, Jae Jin

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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases von Coll, Rebecca C, Robertson, Avril A B, Chae, Jae Jin, Higgins, Sarah C, Muñoz-Planillo, Raúl, Inserra, Marco C, Vetter, Irina, Dungan, Lara S, Monks, Brian G, Stutz, Andrea, Croker, Daniel E, Butler, Mark S, Haneklaus, Moritz, Sutton, Caroline E, Núñez, Gabriel, Latz, Eicke, Kastner, Daniel L, Mills, Kingston H G, Masters, Seth L, Schroder, Kate, Cooper, Matthew A, O'Neill, Luke A J

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The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome von Chung, Lawton K., Park, Yong Hwan, Zheng, Yueting, Brodsky, Igor E., Hearing, Patrick, Kastner, Daniel L., Chae, Jae Jin, Bliska, James B.

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Gain-of-Function Pyrin Mutations Induce NLRP3 Protein -Independent Interleukin-1β Activation and Severe Autoinflammation in Mice von Chae, Jae Jin, Cho, Young-Hun, Lee, Geun-Shik, Cheng, Jun, Liu, P. Paul, Feigenbaum, Lionel, Katz, Stephen I., Kastner, Daniel L.

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Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease von Zhou, Qing, Yu, Xiaomin, Demirkaya, Erkan, Deuitch, Natalie, Stone, Deborah, Tsai, Wanxia Li, Kuehn, Hye Sun, Wang, Hongying, Yang, Dan, Park, Yong Hwan, Ombrello, Amanda K., Blake, Mary, Romeo, Tina, Remmers, Elaine F., Chae, Jae Jin, Mullikin, James C., Güzel, Ferhat, Milner, Joshua D., Boehm, Manfred, Rosenzweig, Sergio D., Gadina, Massimo, Welch, Steven B., Özen, Seza, Topaloglu, Rezan, Abinun, Mario, Kastner, Daniel L., Aksentijevich, Ivona

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Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production von Brehm, Anja, Liu, Yin, Sheikh, Afzal, Marrero, Bernadette, Omoyinmi, Ebun, Zhou, Qing, Montealegre, Gina, Biancotto, Angelique, Reinhardt, Adam, Almeida de Jesus, Adriana, Pelletier, Martin, Tsai, Wanxia L, Remmers, Elaine F, Kardava, Lela, Hill, Suvimol, Kim, Hanna, Lachmann, Helen J, Megarbane, Andre, Chae, Jae Jin, Brady, Jilian, Castillo, Rhina D, Brown, Diane, Casano, Angel Vera, Gao, Ling, Chapelle, Dawn, Huang, Yan, Stone, Deborah, Chen, Yongqing, Sotzny, Franziska, Lee, Chyi-Chia Richard, Kastner, Daniel L, Torrelo, Antonio, Zlotogorski, Abraham, Moir, Susan, Gadina, Massimo, McCoy, Phil, Wesley, Robert, Rother, Kristina I, Rother, Kristina, Hildebrand, Peter W, Brogan, Paul, Krüger, Elke, Aksentijevich, Ivona, Goldbach-Mansky, Raphaela

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Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages von Sokolowska, Milena, Chen, Li-Yuan, Liu, Yueqin, Martinez-Anton, Asuncion, Qi, Hai-Yan, Logun, Carolea, Alsaaty, Sara, Park, Yong Hwan, Kastner, Daniel L, Chae, Jae Jin, Shelhamer, James H

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The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion von Xia, Yu, Liu, Na, Xie, Xiuxiu, Bi, Guoyu, Ba, Hongping, Li, Lin, Zhang, Jinxia, Deng, Xiaofei, Yao, Yao, Tang, Zhaohui, Yin, Binjiao, Wang, Jing, Jiang, Kan, Li, Zhuoya, Choi, Yongwon, Gong, Feili, Cheng, Xiang, O'Shea, John J, Chae, Jae Jin, Laurence, Arian, Yang, Xiang-Ping

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Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis von Park, Yong Hwan, Remmers, Elaine F., Lee, Wonyong, Ombrello, Amanda K., Chung, Lawton K., Shilei, Zhao, Stone, Deborah L., Ivanov, Maya I., Loeven, Nicole A., Barron, Karyl S., Hoffmann, Patrycja, Nehrebecky, Michele, Akkaya-Ulum, Yeliz Z., Sag, Erdal, Balci-Peynircioglu, Banu, Aksentijevich, Ivona, Gül, Ahmet, Rotimi, Charles N., Chen, Hua, Bliska, James B., Ozen, Seza, Kastner, Daniel L., Shriner, Daniel, Chae, Jae Jin

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Control of the innate immune response by the mevalonate pathway von Akula, Murali K, Shi, Man, Jiang, Zhaozhao, Foster, Celia E, Miao, David, Li, Annie S, Zhang, Xiaoman, Gavin, Ruth M, Forde, Sorcha D, Germain, Gail, Carpenter, Susan, Rosadini, Charles V, Gritsman, Kira, Chae, Jae Jin, Hampton, Randolph, Silverman, Neal, Gravallese, Ellen M, Kagan, Jonathan C, Fitzgerald, Katherine A, Kastner, Daniel L, Golenbock, Douglas T, Bergo, Martin O, Wang, Donghai

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Familial Mediterranean fever-related miR-197-3p targets IL1R1 gene and modulates inflammation in monocytes and synovial fibroblasts von Akkaya-Ulum, Yeliz Z., Akbaba, Tayfun Hilmi, Tavukcuoglu, Zeynep, Chae, Jae Jin, Yilmaz, Engin, Ozen, Seza, Balci-Peynircioglu, Banu

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Excess Serum Interleukin‐18 Distinguishes Patients With Pathogenic Mutations in PSTPIP1 von Stone, Deborah L., Ombrello, Amanda, Arostegui, Juan I., Schneider, Corinne, Dang, Vinh, Jesus, Adriana, Girard‐Guyonvarc'h, Charlotte, Gabay, Cem, Lee, Wonyong, Chae, Jae Jin, Aksentijevich, Ivona, Goldbach‐Mansky, Raphaela T., Kastner, Daniel L., Canna, Scott W.

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The B30.2 Domain of Pyrin, the Familial Mediterranean Fever Protein, Interacts Directly with Caspase-1 to Modulate IL-1β Production von Chae, Jae Jin, Wood, Geryl, Masters, Seth L., Richard, Katharina, Park, Grace, Smith, Brian J., Kastner, Daniel L.

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Single amino acid charge switch defines clinically distinct proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1)–associated inflammatory diseases von Holzinger, Dirk, MD, Fassl, Selina Kathleen, MSc, de Jager, Wilco, PhD, Lohse, Peter, MD, Röhrig, Ute F., PhD, Gattorno, Marco, MD, Omenetti, Alessia, MD, Chiesa, Sabrina, MD, Schena, Francesca, PhD, Austermann, Judith, PhD, Vogl, Thomas, PhD, Kuhns, Douglas B., PhD, Holland, Steven M., MD, Rodríguez-Gallego, Carlos, PhD, López-Almaraz, Ricardo, MD, Arostegui, Juan I., MD, PhD, Colino, Elena, MD, Roldan, Rosa, MD, PhD, Fessatou, Smaragdi, MD, Isidor, Bertrand, MD, Poignant, Sylvaine, MD, Ito, Koichi, MD, Epple, Hans-Joerg, MD, Bernstein, Jonathan A., MD, PhD, Jeng, Michael, MD, Frankovich, Jennifer, MD, Lionetti, Geraldina, MD, Church, Joseph A., MD, Ong, Peck Y., MD, PhD, LaPlant, Mona, MD, Abinun, Mario, MD, Skinner, Rod, MD, Bigley, Venetia, MD, Sachs, Ulrich J., MD, PhD, Hinze, Claas, MD, Hoppenreijs, Esther, MD, Ehrchen, Jan, MD, PhD, Foell, Dirk, MD, Chae, Jae Jin, PhD, Ombrello, Amanda, MD, Aksentijevich, Ivona, MD, PhD, Sunderkoetter, Cord, MD, Roth, Johannes, MD

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Galantamine attenuates autoinflammation in a mouse model of familial mediterranean fever von Mughrabi, Ibrahim T, Ochani, Mahendar, Tanovic, Mirza, Wang, Ping, Diamond, Betty, Sherry, Barbara, Pavlov, Valentin A, Ozen, Seza, Kastner, Daniel L, Chae, Jae Jin, Al-Abed, Yousef

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The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis von Dumas, Aline, Amiable, Nathalie, de Rivero Vaccari, Juan Pablo, Chae, Jae Jin, Keane, Robert W, Lacroix, Steve, Vallières, Luc

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Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome von Simon, Anna, Park, Heiyoung, Maddipati, Ravikanth, Lobito, Adrian A, Bulua, Ariel C, Jackson, Adrianna J, Chae, Jae Jin, Ettinger, Rachel, de Koning, Heleen D, Cruz, Anthony C, Kastner, Daniel L, Komarow, Hirsh, Siegel, Richard M

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The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-κB through its N-terminal fragment von Chae, Jae Jin, Wood, Geryl, Richard, Katharina, Jaffe, Howard, Colburn, Nona T., Masters, Seth L., Gumucio, Deborah L., Shoham, Nitza G., Kastner, Daniel L.

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