AlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein Interactions von Yasgar, Adam, Jadhav, Ajit, Simeonov, Anton, Coussens, Nathan P.

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The NCATS BioPlanet - An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics von Huang, Ruili, Grishagin, Ivan, Wang, Yuhong, Zhao, Tongan, Greene, Jon, Obenauer, John C, Ngan, Deborah, Nguyen, Dac-Trung, Guha, Rajarshi, Jadhav, Ajit, Southall, Noel, Simeonov, Anton, Austin, Christopher P

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Pharos: Collating protein information to shed light on the druggable genome von Nguyen, Dac-Trung, Mathias, Stephen, Bologa, Cristian, Brunak, Soren, Fernandez, Nicolas, Gaulton, Anna, Hersey, Anne, Holmes, Jayme, Jensen, Lars Juhl, Karlsson, Anneli, Liu, Guixia, Ma'ayan, Avi, Mandava, Geetha, Mani, Subramani, Mehta, Saurabh, Overington, John, Patel, Juhee, Rouillard, Andrew D, Schürer, Stephan, Sheils, Timothy, Simeonov, Anton, Sklar, Larry A, Southall, Noel, Ursu, Oleg, Vidovic, Dusica, Waller, Anna, Yang, Jeremy, Jadhav, Ajit, Oprea, Tudor I, Guha, Rajarshi

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Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy von Stafford, WC, Peng, XX, Olofsson, MH, Zhang, XN, Luci, DK, Lu, L, Cheng, Q, Tresaugues, L, Dexheimer, TS, Coussens, NP, Augsten, M, Ahlzen, HSM, Orwar, O, Ostman, A, Stone-Elander, S, Maloney, DJ, Jadhav, A, Simeonov, A, Linder, S, Arner, ESJ

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Highly predictive and interpretable models for PAMPA permeability von Sun, Hongmao, Nguyen, Kimloan, Kerns, Edward, Yan, Zhengyin, Yu, Kyeong Ri, Shah, Pranav, Jadhav, Ajit, Xu, Xin

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A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses von Liang, Qin, Dexheimer, Thomas S, Zhang, Ping, Rosenthal, Andrew S, Villamil, Mark A, You, Changjun, Zhang, Qiuting, Chen, Junjun, Ott, Christine A, Sun, Hongmao, Luci, Diane K, Yuan, Bifeng, Simeonov, Anton, Jadhav, Ajit, Xiao, Hui, Wang, Yinsheng, Maloney, David J, Zhuang, Zhihao

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High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells von Griner, Lesley A. Mathews, Guha, Rajarshi, Shinn, Paul, Young, Ryan M., Keller, Jonathan M., Liu, Dongbo, Goldlust, Ian S., Yasgar, Adam, McKnight, Crystal, Boxer, Matthew B., Duveau, Damien Y., Jiang, Jian-Kang, Michael, Sam, Mierzwa, Tim, Huang, Wenwei, Walsh, Martin J., Mott, Bryan T., Patel, Paresma, Leister, William, Maloney, David J., Leclair, Christopher A., Rai, Ganesha, Jadhav, Ajit, Peyser, Brian D., Austin, Christopher P., Martin, Scott E., Simeonov, Anton, Ferrer, Marc, Staudt, Louis M., Thomas, Craig J.

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Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy von Kenny, Hilary A., Lal-Nag, Madhu, White, Erin A., Shen, Min, Chiang, Chun-Yi, Mitra, Anirban K., Zhang, Yilin, Curtis, Marion, Schryver, Elizabeth M., Bettis, Sam, Jadhav, Ajit, Boxer, Matthew B., Li, Zhuyin, Ferrer, Marc, Lengyel, Ernst

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Quantitative High-Throughput Screening: A Titration-Based Approach That Efficiently Identifies Biological Activities in Large Chemical Libraries von Inglese, James, Auld, Douglas S., Jadhav, Ajit, Johnson, Ronald L., Simeonov, Anton, Yasgar, Adam, Zheng, Wei, Austin, Christopher P.

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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH) von Rai, Ganesha, Brimacombe, Kyle R, Mott, Bryan T, Urban, Daniel J, Hu, Xin, Yang, Shyh-Ming, Lee, Tobie D, Cheff, Dorian M, Kouznetsova, Jennifer, Benavides, Gloria A, Pohida, Katie, Kuenstner, Eric J, Luci, Diane K, Lukacs, Christine M, Davies, Douglas R, Dranow, David M, Zhu, Hu, Sulikowski, Gary, Moore, William J, Stott, Gordon M, Flint, Andrew J, Hall, Matthew D, Darley-Usmar, Victor M, Neckers, Leonard M, Dang, Chi V, Waterson, Alex G, Simeonov, Anton, Jadhav, Ajit, Maloney, David J

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Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol von Manthei, Kelly A, Yang, Shyh-Ming, Baljinnyam, Bolormaa, Chang, Louise, Glukhova, Alisa, Yuan, Wenmin, Freeman, Lita A, Maloney, David J, Schwendeman, Anna, Remaley, Alan T, Jadhav, Ajit, Tesmer, John Jg

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A High-Throughput Screen for Aggregation-Based Inhibition in a Large Compound Library von Feng, Brian Y, Simeonov, Anton, Jadhav, Ajit, Babaoglu, Kerim, Inglese, James, Shoichet, Brian K, Austin, Christopher P

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Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites von Dorjsuren, Dorjbal, Eastman, Richard T., Wicht, Kathryn J., Jansen, Daniel, Talley, Daniel C., Sigmon, Benjamin A., Zakharov, Alexey V., Roncal, Norma, Girvin, Andrew T., Antonova-Koch, Yevgeniya, Will, Paul M., Shah, Pranav, Sun, Hongmao, Klumpp-Thomas, Carleen, Mok, Sachel, Yeo, Tomas, Meister, Stephan, Marugan, Juan Jose, Ross, Leila S., Xu, Xin, Maloney, David J., Jadhav, Ajit, Mott, Bryan T., Sciotti, Richard J., Winzeler, Elizabeth A., Waters, Norman C., Campbell, Robert F., Huang, Wenwei, Simeonov, Anton, Fidock, David A.

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A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN) von Sommers, Joshua A, Kulikowicz, Tomasz, Croteau, Deborah L, Dexheimer, Thomas, Dorjsuren, Dorjbal, Jadhav, Ajit, Maloney, David J, Simeonov, Anton, Bohr, Vilhelm A, Brosh, Jr, Robert M

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Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke Therapies von Rai, Ganesha, Joshi, Netra, Jung, Joo Eun, Liu, Yu, Schultz, Lena, Yasgar, Adam, Perry, Steve, Diaz, Giovanni, Zhang, Qiangli, Kenyon, Victor, Jadhav, Ajit, Simeonov, Anton, Lo, Eng H, van Leyen, Klaus, Maloney, David J, Holman, Theodore R

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A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells von Asawa, Rosita R., Danchik, Carina, Zakharov, Alexey, Chen, Yuchi, Voss, Ty, Jadhav, Ajit, Wallace, Darren P., Trott, Josephine F., Weiss, Robert H., Simeonov, Anton, Martinez, Natalia J.

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A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model von Dorjsuren, Dorjbal, Eastman, Richard T, Song, Min Jae, Yasgar, Adam, Chen, Yuchi, Bharti, Kapil, Zakharov, Alexey V, Jadhav, Ajit, Ferrer, Marc, Shi, Pei-Yong, Simeonov, Anton

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Synthesis, Biological Evaluation, and Structure–Activity Relationships of a Novel Class of Apurinic/Apyrimidinic Endonuclease 1 Inhibitors von Rai, Ganesha, Vyjayanti, Vaddadi N, Dorjsuren, Dorjbal, Simeonov, Anton, Jadhav, Ajit, Wilson, David M, Maloney, David J

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Varied Role of Ubiquitylation in Generating MHC Class I Peptide Ligands von Wei, Jiajie, Zanker, Damien, Di Carluccio, Anthony R, Smelkinson, Margery G, Takeda, Kazuyo, Seedhom, Mina O, Dersh, Devin, Gibbs, James S, Yang, Ning, Jadhav, Ajit, Chen, Weisan, Yewdell, Jonathan W

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Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a von Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M, Wasney, Gregory A, Dong, Aiping, Barsyte, Dalia, Kozieradzki, Ivona, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Kireev, Dmitri B, Jadhav, Ajit, Herold, J. Martin, Frye, Stephen V, Arrowsmith, Cheryl H, Brown, Peter J, Simeonov, Anton, Vedadi, Masoud, Jin, Jian

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