Natural products modulating the hERG channel: heartaches and hope von Kratz, Jadel M, Grienke, Ulrike, Scheel, Olaf, Mann, Stefan A, Rollinger, Judith M

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Experimentally Validated hERG Pharmacophore Models as Cardiotoxicity Prediction Tools von Kratz, Jadel M, Schuster, Daniela, Edtbauer, Michael, Saxena, Priyanka, Mair, Christina E, Kirchebner, Julia, Matuszczak, Barbara, Baburin, Igor, Hering, Steffen, Rollinger, Judith M

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2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling von Ferreira, Rafael Augusto Alves, Junior, Celso de Oliveira Rezende, Martinez, Pablo David Grigol, Koovits, Paul John, Soares, Bruna Miranda, Ferreira, Leonardo L G, Michelan-Duarte, Simone, Chelucci, Rafael Consolin, Andricopulo, Adriano D, Galuppo, Mariana K, Uliana, Silvia R B, Matheeussen, An, Caljon, Guy, Maes, Louis, Campbell, Simon, Kratz, Jadel M, Mowbray, Charles E, Dias, Luiz Carlos

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Chagas Disease Drug Discovery in Latin America-A Mini Review of Antiparasitic Agents Explored Between 2010 and 2021 von de Oliveira, Ramon G, Cruz, Luiza R, Mollo, María C, Dias, Luiz C, Kratz, Jadel M

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Synthesis and Anti-Trypanosoma cruzi Activity of 3‑Cyanopyridine Derivatives von Slafer, Brian W., Dessoy, Marco A., de Oliveira, Ramon G., Mollo, Maria C., Lee, Eun, Matheeussen, An, Maes, Louis, Caljon, Guy, Ferreira, Leonardo L. G., Krogh, Renata, Andricopulo, Adriano D., Cruz, Luiza R., Mowbray, Charles E., Kratz, Jadel M., Dias, Luiz C.

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In Silico Workflow for the Discovery of Natural Products Activating the G Protein-Coupled Bile Acid Receptor 1 von Kirchweger, Benjamin, Kratz, Jadel M, Ladurner, Angela, Grienke, Ulrike, Langer, Thierry, Dirsch, Verena M, Rollinger, Judith M

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Chemical Constituents and Pharmacology properties of Aristolochia triangularis: a south brazilian highly-consumed botanical with multiple bioactivities von Oliveira, Simone Q, Kratz, Jadel M, Chaves, Vitor C, Guimarães, Tatiana R, Costa, Danielle T M, Dimitrakoudi, Sapfo, Vontzalidou, Argyro, Bordignon, Sérgio A L, Simionato, Cesar P, Steindel, Mário, Reginatto, Flávio H, Simões, Cláudia M O, Schenkel, Eloir P

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The translational challenge in Chagas disease drug development von Kratz, Jadel M, Gonçalves, Karolina R, Romera, Lavínia Md, Moraes, Carolina Borsoi, Bittencourt-Cunha, Paula, Schenkman, Sergio, Chatelain, Eric, Sosa-Estani, Sergio

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Development and validation of ultra-performance liquid chromatography tandem mass spectrometry methods for the quantitative analysis of the antiparasitic drug DNDI-6148 in human pl... von Schouten, Wietse M., Van Bocxlaer, Katrien, Rosing, Hilde, Huitema, Alwin D.R., Beijnen, Jos H., Kratz, Jadel M., Mowbray, Charles E., Dorlo, Thomas P.C.

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Design, synthesis, and lead optimization of piperazinyl-pyrimidine analogues as potent small molecules targeting the viral capping machinery of Chikungunya virus von Battisti, Verena, Moesslacher, Julia, Abdelnabi, Rana, Leyssen, Pieter, Rosales Rosas, Ana Lucia, Langendries, Lana, Aufy, Mohammed, Studenik, Christian, Kratz, Jadel M, Rollinger, Judith M, Puerstinger, Gerhard, Neyts, Johan, Delang, Leen, Urban, Ernst, Langer, Thierry

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Demystifying In Vivo Bioluminescence Imaging of a Chagas Disease Mouse Model for Drug Efficacy Studies von da Silva, Adriana C, Kratz, Jadel M, Morgado, Priscylla G M, Freitas-Junior, Lucio H, Moraes, Carolina B

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Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease von de Oliveira Rezende Júnior, Celso, Martinez, Pablo David Grigol, Ferreira, Rafael Augusto Alves, Koovits, Paul John, Miranda Soares, Bruna, Ferreira, Leonardo L.G., Michelan-Duarte, Simone, Chelucci, Rafael Consolin, Andricopulo, Adriano D., Matheeussen, An, Van Pelt, Natascha, Caljon, Guy, Maes, Louis, Campbell, Simon, Kratz, Jadel M., Mowbray, Charles E., Dias, Luiz Carlos

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Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi von Koovits, Paul J., Dessoy, Marco A., Matheeussen, An, Maes, Louis, Caljon, Guy, Mowbray, Charles E., Kratz, Jadel M., Dias, Luiz C.

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Constrained H‑Phe-Phe-NH2 Analogues with High Affinity to the Substance P 1–7 Binding Site and with Improved Metabolic Stability and Cell Permeability von Fransson, Rebecca, Sköld, Christian, Kratz, Jadel M, Svensson, Richard, Artursson, Per, Nyberg, Fred, Hallberg, Mathias, Sandström, Anja

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Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents von Koovits, Paul J, Dessoy, Marco A, Matheeussen, An, Maes, Louis, Caljon, Guy, Ferreira, Leonardo L. G, Chelucci, Rafael C, Michelan-Duarte, Simone, Andricopulo, Adriano D, Campbell, Simon, Kratz, Jadel M, Mowbray, Charles E, Dias, Luiz C

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Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen von Francisco, Amanda F., Chen, Gong, Wang, Wen, Sykes, Melissa L., Escudié, Fanny, Scandale, Ivan, Olmo, Francisco, Shackleford, David M., Zulfiqar, Bilal, Kratz, Jadel M., Pham, Thao, Saunders, Jessica, Hu, Meiyu, Avery, Vicky M., Charman, Susan A., Kelly, John M., Chatelain, Eric

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Constrained H-Phe-Phe-NH 2 Analogues with High Affinity to the Substance P 1–7 Binding Site and with Improved Metabolic Stability and Cell Permeability von Fransson, Rebecca, Sköld, Christian, Kratz, Jadel M., Svensson, Richard, Artursson, Per, Nyberg, Fred, Hallberg, Mathias, Sandström, Anja

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Solid dispersions enhance solubility, dissolution, and permeability of thalidomide von Barea, Silvana A., Mattos, Cristiane B., Cruz, Ariadne C. C., Chaves, Vitor C., Pereira, Rafael N., Simões, Claudia M. O., Kratz, Jadel M., Koester, Letícia S.

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Enzymatic synthesis of ascorbyl ester derived from linoleic acid von Balen, Manuela, Gomes, Gabriela Rotta, Kratz, Jadel M., Simões, Cláudia M. O., Valério, Alexsandra, de Oliveira, Débora

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Exploration and Pharmacokinetic Profiling of Phenylalanine Based Carbamates as Novel Substance P 1–7 Analogues von Fransson, Rebecca, Nordvall, Gunnar, Bylund, Johan, Carlsson-Jonsson, Anna, Kratz, Jadel M, Svensson, Richard, Artursson, Per, Hallberg, Mathias, Sandström, Anja

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