A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis von Krueger, James G, Suárez-Fariñas, Mayte, Cueto, Inna, Khacherian, Artemis, Matheson, Robert, Parish, Lawrence C, Leonardi, Craig, Shortino, Denise, Gupta, Akanksha, Haddad, Jonathan, Vlasuk, George P, Jacobson, Eric W

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Joint Genetic Susceptibility to Type 1 Diabetes and Autoimmune Thyroiditis: from Epidemiology to Mechanisms von Huber, Amanda, Menconi, Francesca, Corathers, Sarah, Jacobson, Eric M, Tomer, Yaron

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The HLA gene complex in thyroid autoimmunity: From epidemiology to etiology von Jacobson, Eric M, Huber, Amanda, Tomer, Yaron

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Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis von Wada, Yumiko, Cardinale, Irma, Khatcherian, Artemis, Chu, John, Kantor, Aaron B, Gottlieb, Alice B, Tatsuta, Noriaki, Jacobson, Eric, Barsoum, James, Krueger, James G

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The CD40 , CTLA-4 , thyroglobulin , TSH receptor , and PTPN22 gene quintet and its contribution to thyroid autoimmunity: Back to the future von Jacobson, Eric M, Tomer, Yaron

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The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans von van der Meer, Anne J, Scicluna, Brendon P, Moerland, Perry D, Lin, Jiang, Jacobson, Eric W, Vlasuk, George P, van der Poll, Tom

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A phase II, randomized, placebo‐controlled, double‐blind, multi‐dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes von Baksi, Arun, Kraydashenko, Oleg, Zalevkaya, Alsu, Stets, Roman, Elliott, Peter, Haddad, Jonathan, Hoffmann, Ethan, Vlasuk, George P., Jacobson, Eric W.

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Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome von Kaptchuk, Ted J, Kelley, John M, Conboy, Lisa A, Davis, Roger B, Kerr, Catherine E, Jacobson, Eric E, Kirsch, Irving, Schyner, Rosa N, Nam, Bong Hyun, Nguyen, Long T, Park, Min, Rivers, Andrea L, McManus, Claire, Kokkotou, Efi, Drossman, Douglas A, Goldman, Peter, Lembo, Anthony J

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Pharmacokinetics and tolerability of SRT2104, a first‐in‐class small molecule activator of SIRT1, after single and repeated oral administration in man von Hoffmann, Ethan, Wald, Jeff, Lavu, Siva, Roberts, John, Beaumont, Claire, Haddad, Jon, Elliott, Peter, Westphal, Christoph, Jacobson, Eric

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A Graves’ Disease-Associated Kozak Sequence Single-Nucleotide Polymorphism Enhances the Efficiency of CD40 Gene Translation: A Case for Translational Pathophysiology von Jacobson, Eric M, Concepcion, Erlinda, Oashi, Taiji, Tomer, Yaron

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Phase II, Randomized, Controlled, Double-Blinded Trial of Weekly Elesclomol Plus Paclitaxel Versus Paclitaxel Alone for Stage IV Metastatic Melanoma von O'DAY, Steven, GONZALEZ, Rene, LAWSON, David, WEBER, Robert, HUTCHINS, Laura, ANDERSON, Clay, HADDAD, Jonathan, KONG, Steven, WILLIAMS, Anthony, JACOBSON, Eric

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Suppression of Breast Cancer by Small Molecules That Block the Prolactin Receptor von Borcherding, Dana C., Hugo, Eric R., Fox, Sejal R., Jacobson, Eric M., Hunt, Brian G., Merino, Edward J., Ben-Jonathan, Nira

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Interleukin (IL)-23 Receptor Is a Major Susceptibility Gene for Graves’ Ophthalmopathy: The IL-23/T-helper 17 Axis Extends to Thyroid Autoimmunity von Huber, Amanda K., Jacobson, Eric M., Jazdzewski, Krystian, Concepcion, Erlinda S., Tomer, Yaron

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Randomized, double‐blind, placebo‐controlled trial of the oral interleukin‐12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease von Sands, Bruce E., Jacobson, Eric W., Sylwestrowicz, Thomas, Younes, Ziad, Dryden, Gerald, Fedorak, Richard, Greenbloom, Susan

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Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis von Li, Cheuk Wun, Menconi, Francesca, Osman, Roman, Mezei, Mihaly, Jacobson, Eric M., Concepcion, Erlinda, David, Chella S., Kastrinsky, David B., Ohlmeyer, Michael, Tomer, Yaron

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A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers von Libri, Vincenzo, Brown, Andrew P, Gambarota, Giulio, Haddad, Jonathan, Shields, Gregory S, Dawes, Helen, Pinato, David J, Hoffman, Ethan, Elliot, Peter J, Vlasuk, George P, Jacobson, Eric, Wilkins, Martin R, Matthews, Paul M

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Cardiovascular Effects of a Novel SIRT1 Activator, SRT2104, in Otherwise Healthy Cigarette Smokers von Venkatasubramanian, Sowmya, Noh, Radzi Mohd, Daga, Shruti, Langrish, Jeremy P., Joshi, Nikhil V., Mills, Nicholas L., Hoffmann, Ethan, Jacobson, Eric W., Vlasuk, George P., Waterhouse, Brian R., Lang, Ninian N., Newby, David E.

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Novel Variant of Thyroglobulin Promoter Triggers Thyroid Autoimmunity through an Epigenetic Interferon α-modulated Mechanism von Stefan, Mihaela, Jacobson, Eric M., Huber, Amanda K., Greenberg, David A., Li, Cheuk Wun, Skrabanek, Luce, Conception, Erlinda, Fadlalla, Mohammed, Ho, Kenneth, Tomer, Yaron

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“Maybe I Made Up the Whole Thing”: Placebos and Patients’ Experiences in a Randomized Controlled Trial von Kaptchuk, Ted J., Shaw, Jessica, Kerr, Catherine E., Conboy, Lisa A., Kelley, John M., Csordas, Thomas J., Lembo, Anthony J., Jacobson, Eric E.

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Genetically driven target tissue overexpression of CD40: a novel mechanism in autoimmune disease von Huber, Amanda K, Finkelman, Fred D, Li, Cheuk Wun, Concepcion, Erlinda, Smith, Eric, Jacobson, Eric, Latif, Rauf, Keddache, Mehdi, Zhang, Weijia, Tomer, Yaron

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