Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity von Jacobsen, Helle J, Poulsen, Thomas T, Dahlman, Anna, Kjær, Ida, Koefoed, Klaus, Sen, Jette W, Weilguny, Dietmar, Bjerregaard, Bolette, Andersen, Christina R, Horak, Ivan D, Pedersen, Mikkel W, Kragh, Michael, Lantto, Johan

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Sym015: A Highly Efficacious Antibody Mixture against MET -Amplified Tumors von Poulsen, Thomas Tuxen, Grandal, Michael Monrad, Skartved, Niels Jørgen Østergaard, Hald, Rikke, Alifrangis, Lene, Koefoed, Klaus, Lindsted, Trine, Fröhlich, Camilla, Pollmann, Sofie Ellebæk, Eriksen, Karsten Wessel, Dahlman, Anna, Jacobsen, Helle Jane, Bouquin, Thomas, Pedersen, Mikkel Wandahl, Horak, Ivan David, Lantto, Johan, Kragh, Michael

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Targeting Three Distinct HER2 Domains with a Recombinant Antibody Mixture Overcomes Trastuzumab Resistance von Pedersen, Mikkel W, Jacobsen, Helle J, Koefoed, Klaus, Dahlman, Anna, Kjær, Ida, Poulsen, Thomas T, Meijer, Per-Johan, Nielsen, Lars S, Horak, Ivan D, Lantto, Johan, Kragh, Michael

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Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms von Grandal, Michael M, Havrylov, Serhiy, Poulsen, Thomas T, Koefoed, Klaus, Dahlman, Anna, Galler, Gunther R, Conrotto, Paolo, Collins, Sara, Eriksen, Karsten W, Kaufman, Dafna, Woude, George F Vande, Jacobsen, Helle J, Horak, Ivan D, Kragh, Michael, Lantto, Johan, Bouquin, Thomas, Park, Morag, Pedersen, Mikkel W

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Comparison of antibiotic prescribing and antimicrobial resistance in urinary tract infections at the municipal level among women in two Nordic regions von Nygaard Jensen, Jette, Melander, Eva, Hedin, Katarina, Bjerrum, Lars, Kornfält Isberg, Helena, Holm, Anne, Neel Jacobsen, Helle, Skovby, Annette, Córdoba Currea, Gloria Cristina, Hyllebusk, Lena, Brogaard, Emma, Arpi, Magnus

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A functional and structural basis for TCR cross-reactivity in multiple sclerosis von Jones, E. Yvonne, Fugger, Lars, Lang, Heather L.E, Jacobsen, Helle, Ikemizu, Shinji, Andersson, Christina, Harlos, Karl, Madsen, Lars, Hjorth, Peter, Sondergaard, Leif, Svejgaard, Arne, Wucherpfennig, Kai, Stuart, David I, Bell, John I

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Abstract 1219: Sym015, a novel antibody mixture targeting non-overlapping epitopes of MET, effectively inhibits growth of MET dependent tumors and overcomes resistance to a single... von Poulsen, Thomas T., Grandal, Michael M., Jacobsen, Helle J., Hansen, Dorte S., Lindsted, Trine, Pedersen, Mikkel W., Horak, Ivan D., Kragh, Michael, Lantto, Johan

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In vivo imaging of therapy response to a novel pan-HER antibody mixture using FDG and FLT positron emission tomography von Nielsen, Carsten H, Jensen, Mette M, Kristensen, Lotte K, Dahlman, Anna, Fröhlich, Camilla, Jacobsen, Helle J, Poulsen, Thomas T, Lantto, Johan, Horak, Ivan D, Kragh, Michael, Kjaer, Andreas

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Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor von Koefoed, Klaus, Steinaa, Lucilla, Søderberg, Josefine Nielsen, Kjær, Ida, Jacobsen, Helle Jane, Meijer, Per-Johan, Haurum, John Sørensen, Jensen, Allan, Kragh, Michael, Andersen, Peter Sejer, Pedersen, Mikkel Wandahl

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Preclinical Pharmacokinetics and Safety of Sym004: A Synergistic Antibody Mixture Directed against Epidermal Growth Factor Receptor von SKARTVED, Niels Jørgen Østergaard, JACOBSEN, Helle Jane, PEDERSEN, Mikkel Wandahl, JENSEN, Pernille Foged, SEN, Jette Wagtberg, JORGENSEN, Thomas Kjærsgaard, HEY, Adam, KRAGH, Michael

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Sym004: A Novel Synergistic Anti-Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy von PEDERSEN, Mikkel Wandahl, JACOBSEN, Helle Jane, KOEFOED, Klaus, HEY, Adam, PYKE, Charles, HAURUM, John Sørensen, KRAGH, Michael

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Myelin oligodendrocyte glycoprotein‐35–55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA‐DR2‐transgenic mice von Rich, Cathleen, Link, Jason M., Zamora, Alex, Jacobsen, Helle, Meza‐Romero, Roberto, Offner, Halina, Jones, Richard, Burrows, Gregory G., Fugger, Lars, Vandenbark, Arthur A.

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Abstract 657: Simultaneous inhibition of HER-family receptors by Pan-HER antibody mixture prevents compensatory HER-family receptor upregulation and induces cell death in a broad r... von Dahlman, Anna, Jacobsen, Helle J., Poulsen, Thomas T., Conrotto, Paolo, Pedersen, Mikkel W., Horak, Ivan D., Kragh, Michael, Lantto, Johan

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Abstract 2070: In vivo imaging of therapy response to novel antibody mixtures targeted at the human epidermal growth factor receptor family using FDG and FLT positron emission tomo... von Nielsen, Carsten H., Jensen, Mette M., Jacobsen, Helle J., Poulsen, Thomas T., Horak, Ivan D., Lantto, Johan, Kragh, Michael, Kjaer, Andreas

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Abstract 1218: A novel synergistic antibody pair targeting non-overlapping epitopes of MET effectively inhibits MET-driven cancer models von Grandal, Michael M., Poulsen, Thomas T., Koefoed, Klaus, Eriksen, Karsten W., Dahlman, Anna, Conrotto, Paolo, Bouquin, Thomas, Jacobsen, Helle, Horak, Ivan D., Kragh, Michael, Lantto, Johan, Pedersen, Mikkel W.

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Abstract 4322: Efficacy of Sym004, a novel anti-EGFR antibody mixture, against EGFRvIII positive glioblastoma xenografts von Keir, Stephen T., Roskoski, Martin A., Kragh, Michael, Pederson, Mikkel W., Jacobsen, Helle J., Horak, Ivan D., Friedman, Henry S., Bigner, Darell D.

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Abstract 4562: Superior targeting of the human epidermal growth factor receptor 2 (HER-2) with recombinant monoclonal antibody mixtures von Pedersen, Mikkel W., Jacobsen, Helle J., Poulsen, Thomas T., Meijer, Per J., Kragh, Michael

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Abstract 1752: Nonclinical safety and pharmacokinetics of Sym004: A synergistic anti-EGF receptor antibody mixture von Skartved, Niels Jørgen, Pedersen, Mikkel W., Jacobsen, Helle, Jørgensen, Thomas K., Kragh, Michael

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Selection of a Novel and Highly Specific Tumor Necrosis Factor α (TNFα) Antagonist: INSIGHT FROM THE CRYSTAL STRUCTURE OF THE ANTAGONIST-TNFα COMPLEX von Byla, Povilas, Andersen, Mikkel H, Holtet, Thor L, Jacobsen, Helle, Munch, Mette, Gad, Hans Henrik, Thøgersen, Hans Christian, Hartmann, Rune

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Abstract 4751: Simultaneous inhibition of EGFR, HER2 and HER3 by an antibody mixture provides broad and potent tumor inhibition von Lantto, Johan, Pedersen, Mikkel W., Jacobsen, Helle J., Poulsen, Thomas T., Kjær, Ida, Koefoed, Klaus, Sen, Jette W., Weilguny, Dietmar, Bjerregaard, Bolette, Andersen, Christina R., Horak, Ivan D., Kragh, Michael

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