SUMO-mediated regulation of NLRP3 modulates inflammasome activity von Barry, Rachael, John, Sidonie Wicky, Liccardi, Gianmaria, Tenev, Tencho, Jaco, Isabel, Chen, Chih-Hong, Choi, Justin, Kasperkiewicz, Paulina, Fernandes-Alnemri, Teresa, Alnemri, Emad, Drag, Marcin, Chen, Yuan, Meier, Pascal

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MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death von Jaco, Isabel, Annibaldi, Alessandro, Lalaoui, Najoua, Wilson, Rebecca, Tenev, Tencho, Laurien, Lucie, Kim, Chun, Jamal, Kunzah, Wicky John, Sidonie, Liccardi, Gianmaria, Chau, Diep, Murphy, James M., Brumatti, Gabriela, Feltham, Rebecca, Pasparakis, Manolis, Silke, John, Meier, Pascal

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A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases von Murchison, Elizabeth, Benetti, Roberta, Klatt, Peter, Gonzalez, Susana, Hannon, Gregory, Andl, Thomas, Li, En, Schoeftner, Stefan, Serrano, Manuel, Blasco, Maria A, Muñoz, Purificación, Millar, Sarah, Gonzalo, Susana, Jaco, Isabel, Chen, Taiping

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Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination von Benetti, Roberta, Gonzalo, Susana, Jaco, Isabel, Schotta, Gunnar, Klatt, Peter, Jenuwein, Thomas, Blasco, María A

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BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping von Tarsounas, Madalena, Badie, Sophie, Escandell, Jose M, Bouwman, Peter, Carlos, Ana Rita, Thanasoula, Maria, Gallardo, Maria M, Suram, Anitha, Jaco, Isabel, Benitez, Javier, Herbig, Utz, Blasco, Maria A, Jonkers, Jos

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Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1’s Cytotoxic Potential von Feltham, Rebecca, Jamal, Kunzah, Tenev, Tencho, Liccardi, Gianmaria, Jaco, Isabel, Domingues, Celia Monteiro, Morris, Otto, John, Sidonie Wicky, Annibaldi, Alessandro, Widya, Marcella, Kearney, Conor J., Clancy, Danielle, Elliott, Paul R., Glatter, Timo, Qiao, Qi, Thompson, Andrew J., Nesvizhskii, Alexey, Schmidt, Alexander, Komander, David, Wu, Hao, Martin, Seamus, Meier, Pascal

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Global chromatin compaction limits the strength of the DNA damage response von Murga, Matilde, Jaco, Isabel, Fan, Yuhong, Soria, Rebeca, Martinez-Pastor, Barbara, Cuadrado, Myriam, Yang, Seung-Min, Blasco, Maria A, Skoultchi, Arthur I, Fernandez-Capetillo, Oscar

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Centromere mitotic recombination in mammalian cells von Jaco, Isabel, Canela, Andrés, Vera, Elsa, Blasco, Maria A

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Functional Interaction between Poly(ADP-Ribose) Polymerase 2 (PARP-2) and TRF2: PARP Activity Negatively Regulates TRF2 von Dantzer, Françoise, Giraud-Panis, Marie-Josèphe, Jaco, Isabel, Amé, Jean-Christophe, Schultz, Inès, Blasco, Maria, Koering, Catherine-Elaine, Gilson, Eric, Ménissier-de Murcia, Josiane, de Murcia, Gilbert, Schreiber, Valérie

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Role of Mammalian Rad54 in Telomere Length Maintenance von Jaco, Isabel, Muñoz, Purificación, Goytisolo, Fermín, Wesoly, Joanna, Bailey, Susan, Taccioli, Guillermo, Blasco, María A.

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DNA methyltransferases control telomere length and telomere recombination in mammalian cells von Blasco, María A, Gonzalo, Susana, Jaco, Isabel, Fraga, Mario F, Chen, Taiping, Li, En, Esteller, Manel

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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers von Ferretti, Stephane, Hamon, Jacques, de Kanter, Ruben, Scheufler, Clemens, Andraos-Rey, Rita, Barbe, Stephanie, Bechter, Elisabeth, Blank, Jutta, Bordas, Vincent, Dammassa, Ernesta, Decker, Andrea, Di Nanni, Noemi, Dourdoigne, Marion, Gavioli, Elena, Hattenberger, Marc, Heuser, Alisa, Hemmerlin, Christelle, Hinrichs, Jürgen, Kerr, Grainne, Laborde, Laurent, Jaco, Isabel, Núñez, Eloísa Jiménez, Martus, Hans-Joerg, Quadt, Cornelia, Reschke, Markus, Romanet, Vincent, Schaeffer, Fanny, Schoepfer, Joseph, Schrapp, Maxime, Strang, Ross, Voshol, Hans, Wartmann, Markus, Welly, Sarah, Zécri, Frédéric, Hofmann, Francesco, Möbitz, Henrik, Cortés-Cros, Marta

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The anticonvulsive Phenhydan® suppresses extrinsic cell death von Moerke, Caroline, Jaco, Isabel, Dewitz, Christin, Müller, Tammo, Jacobsen, Annette V., Gautheron, Jérémie, Fritsch, Jürgen, Schmitz, Jessica, Bräsen, Jan Hinrich, Günther, Claudia, Murphy, James M., Kunzendorf, Ulrich, Meier, Pascal, Krautwald, Stefan

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Los Comités Pueblos Mágicos y el desarrollo turístico: Tepotzotlán y El Oro, Estado de México von Rosas Jaco, María Isabel, Guajardo Hernández, Lenin G, Almeraya Quintero, Silvia Xochilt

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A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases von Benetti, Roberta, Gonzalo, Susana, Jaco, Isabel, Muñoz, Purificación, Gonzalez, Susana, Schoeftner, Stefan, Murchison, Elizabeth, Andl, Thomas, Chen, Taiping, Klatt, Peter, Li, En, Serrano, Manuel, Millar, Sarah, Hannon, Gregory, Blasco, Maria A

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Abstract B143: HRO761, a first-in-class, clinical stage WRN inhibitor with potent preclinical anti-tumor activity in MSIhigh models von Ferretti, Stephane, Jaco, Isabel, Decker, Andrea, Hemmerlin, Christelle, Scheufler, Clemens, Quadt, Cornelia, Sterker, Dario, Gavioli, Elena, Nunez, Eloisa Jimenez, Dammassa, Ernesta, Schaeffer, Fanny, Albrecht, Genevieve, Clementi, Giorgia, Martus, Hansjoerg, Hamon, Jacques, Hinrichs, Juergen, Laborde, Laurent, Dourdoigne, Marion, Moschetta, Michele, Stump, Ramona, Andraos-Rey, Rita, Welly, Sarah, Barbe, Stephanie, Romanet, Vincent, Reschke, Markus, Kanter, Ruben De, Jensen, Michael, Moebitz, Henrik, Cros, Marta Cortes

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Abstract PR007: Discovery of HRO761, a novel, first-in-class clinical stage WRN inhibitor with potent and selective anti-tumor activity in cancers with microsatellite instability von Cortes-Cros, Marta, Moebitz, Henrik, Barbe, Stephanie, Blank, Jutta, Bordas, Vincent, Clementi, Giorgia, Dammassa, Ernesta, Decker, Andrea, Nanni, Noemi Di, de Kanter, Ruben, Dourdoigne, Marion, Gavioli, Elena, Ferretti, Stephane, Hattenberger, Marc, Hemmerlin, Christelle, Hamon, Jacques, Hinrichs, Juergen, Jaco, Isabel, Jankovic, Dragana, Nunez, Eloisa Jimenez, Li, Yifang, Martus, Hans-Joerg, Moschetta, Michele, Quadt, Cornelia, Reschke, Markus, Romanet, Vincent, Scheufler, Clemens, Schoepfer, Joseph, Strang, Ross, Therier, Maxime, Voshol, Hans, Wartmann, Markus, Welly, Sarah, Pham, Monica, Laborde, Laurent

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Mind bomb regulates cell death during TNF signaling by suppressing RIPK1's cytotoxic potential von Feltham, Rebecca, Jamal, Kunzah, Tenev, Tencho, Liccardi, Gianmaria, Jaco, Isabel, Domingues, Celia Monteiro, Morris, Otto, John, Sidonie Wicky, Annibaldi, Alessandro, Widya, Marcella, Kearney, Conor J, Clancy, Danielle, Elliott, Paul R, Glatter, Timo, Qiao, Qi, Thompson, Andrew J, Nesvizhskii, Alexey, Schmidt, Alexander, Komander, David, Wu, Hao, Martin, Seamus, Meier, Pascal

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Role of human Ku86 in telomere length maintenance and telomere capping von JACO, Isabel, MUNOZ, Purificacion, BLASCO, Maria A

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Postreplicative joining of DNA double-strand breaks causes genomic instability in DNA-PKcs-deficient mouse embryonic fibroblasts von MARTIN, Marta, GENESCA, Anna, LATRE, Laura, JACO, Isabel, TACCIOLI, Guillermo E, EGOZCUE, Josep, BLASCO, Maria A, ILIAKIS, George, TUSELL, Laura

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