The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling von Mukhopadhyay, Saikat, Wen, Xiaohui, Ratti, Navneet, Loktev, Alexander, Rangell, Linda, Scales, Suzie J., Jackson, Peter K.

Volltext

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling von Hilgendorf, Keren I, Johnson, Carl T, Jackson, Peter K

Volltext

Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndrome Pathway to Signal in Neuronal Primary Cilia von Loktev, Alexander V., Jackson, Peter K.

Volltext

CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities von Han, Kyuho, Pierce, Sarah E., Li, Amy, Spees, Kaitlyn, Anderson, Gray R., Seoane, Jose A., Lo, Yuan-Hung, Dubreuil, Michael, Olivas, Micah, Kamber, Roarke A., Wainberg, Michael, Kostyrko, Kaja, Kelly, Marcus R., Yousefi, Maryam, Simpkins, Scott W., Yao, David, Lee, Keonil, Kuo, Calvin J., Jackson, Peter K., Sweet-Cordero, Alejandro, Kundaje, Anshul, Gentles, Andrew J., Curtis, Christina, Winslow, Monte M., Bassik, Michael C.

Volltext

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity von Maurer, Till, Garrenton, Lindsay S, Oh, Angela, Pitts, Keith, Anderson, Daniel J, Skelton, Nicholas J, Fauber, Benjamin P, Pan, Borlan, Malek, Shiva, Stokoe, David, Ludlam, Mary J. C, Bowman, Krista K, Wu, Jiansheng, Giannetti, Anthony M, Starovasnik, Melissa A, Mellman, Ira, Jackson, Peter K, Rudolph, Joachim, Wang, Weiru, Fang, Guowei

Volltext

Ethacridine inhibits SARS-CoV-2 by inactivating viral particles von Li, Xiaoquan, Lidsky, Peter V, Xiao, Yinghong, Wu, Chien-Ting, Garcia-Knight, Miguel, Yang, Junjiao, Nakayama, Tsuguhisa, Nayak, Jayakar V, Jackson, Peter K, Andino, Raul, Shu, Xiaokun

Volltext

Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation von Lu, Quanlong, Insinna, Christine, Ott, Carolyn, Stauffer, Jimmy, Pintado, Petra A., Rahajeng, Juliati, Baxa, Ulrich, Walia, Vijay, Cuenca, Adrian, Hwang, Yoo-Seok, Daar, Ira O., Lopes, Susana, Lippincott-Schwartz, Jennifer, Jackson, Peter K., Caplan, Steve, Westlake, Christopher J.

Volltext

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition von Boudreau, Aaron, Purkey, Hans E, Hitz, Anna, Robarge, Kirk, Peterson, David, Labadie, Sharada, Kwong, Mandy, Hong, Rebecca, Gao, Min, Del Nagro, Christopher, Pusapati, Raju, Ma, Shuguang, Salphati, Laurent, Pang, Jodie, Zhou, Aihe, Lai, Tommy, Li, Yingjie, Chen, Zhongguo, Wei, Binqing, Yen, Ivana, Sideris, Steve, McCleland, Mark, Firestein, Ron, Corson, Laura, Vanderbilt, Alex, Williams, Simon, Daemen, Anneleen, Belvin, Marcia, Eigenbrot, Charles, Jackson, Peter K, Malek, Shiva, Hatzivassiliou, Georgia, Sampath, Deepak, Evangelista, Marie, O'Brien, Thomas

Volltext

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death von Magnaghi, Paola, D'Alessio, Roberto, Valsasina, Barbara, Avanzi, Nilla, Rizzi, Simona, Asa, Daniela, Gasparri, Fabio, Cozzi, Liviana, Cucchi, Ulisse, Orrenius, Christian, Polucci, Paolo, Ballinari, Dario, Perrera, Claudia, Leone, Antonella, Cervi, Giovanni, Casale, Elena, Xiao, Yang, Wong, Chihunt, Anderson, Daniel J, Galvani, Arturo, Donati, Daniele, O'Brien, Tom, Jackson, Peter K, Isacchi, Antonella

Volltext

E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family von Hsu, Jenny, Arand, Julia, Chaikovsky, Andrea, Mooney, Nancie A., Demeter, Janos, Brison, Caileen M., Oliverio, Romane, Vogel, Hannes, Rubin, Seth M., Jackson, Peter K., Sage, Julien

Volltext

Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging von Palla, Adelaida R., Hilgendorf, Keren I., Yang, Ann V., Kerr, Jaclyn P., Hinken, Aaron C., Demeter, Janos, Kraft, Peggy, Mooney, Nancie A., Yucel, Nora, Burns, David M., Wang, Yu Xin, Jackson, Peter K., Blau, Helen M.

Volltext

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome von Westlake, Christopher J, Baye, Lisa M, Nachury, Maxence V, Wright, Kevin J, Ervin, Karen E, Phu, Lilian, Chalouni, Cecile, Beck, John S, Kirkpatrick, Donald S, Slusarski, Diane C, Sheffield, Val C, Scheller, Richard H, Jackson, Peter K

Volltext

Nek8 Couples Renal Ciliopathies to DNA Damage and Checkpoint Control von Jackson, Peter K.

Volltext

A fast-acting lipid checkpoint in G1 prevents mitotic defects von Köberlin, Marielle S., Fan, Yilin, Liu, Chad, Chung, Mingyu, Pinto, Antonio F. M., Jackson, Peter K., Saghatelian, Alan, Meyer, Tobias

Volltext

An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium von Wright, Kevin J, Baye, Lisa M, Olivier-Mason, Anique, Mukhopadhyay, Saikat, Sang, Liyun, Kwong, Mandy, Wang, Weiru, Pretorius, Pamela R, Sheffield, Val C, Sengupta, Piali, Slusarski, Diane C, Jackson, Peter K

Volltext

Regulating Microtubules and Genome Stability via the CUL7/3M Syndrome Complex and CUL9 von Jackson, Peter K.

Volltext

Multiplexed screens identify RAS paralogues HRAS and NRAS as suppressors of KRAS-driven lung cancer growth von Tang, Rui, Shuldiner, Emily G., Kelly, Marcus, Murray, Christopher W., Hebert, Jess D., Andrejka, Laura, Tsai, Min K., Hughes, Nicholas W., Parker, Mitchell I., Cai, Hongchen, Li, Yao-Cheng, Wahl, Geoffrey M., Dunbrack, Roland L., Jackson, Peter K., Petrov, Dmitri A., Winslow, Monte M.

Volltext

Tip60-mediated H2A.Z acetylation promotes neuronal fate specification and bivalent gene activation von Janas, Justyna A., Zhang, Lichao, Luu, Jacklyn H., Demeter, Janos, Meng, Lingjun, Marro, Samuele G., Mall, Moritz, Mooney, Nancie A., Schaukowitch, Katie, Ng, Yi Han, Yang, Nan, Huang, Yuhao, Neumayer, Gernot, Gozani, Or, Elias, Joshua E., Jackson, Peter K., Wernig, Marius

Volltext

p73 and FoxJ1: Programming Multiciliated Epithelia von Jackson, Peter K, Attardi, Laura D

Volltext

UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma von Kostyrko, Kaja, Román, Marta, Lee, Alex G., Simpson, David R., Dinh, Phuong T., Leung, Stanley G., Marini, Kieren D., Kelly, Marcus R., Broyde, Joshua, Califano, Andrea, Jackson, Peter K., Sweet-Cordero, E. Alejandro

Volltext