OP 6.6 – 00134 Viral Suppression in SHIV-infected Rhesus Macaques following AAVmediated Delivery of Closer-to-germline Monoclonal Antibodies von Martinez-Navio, J., Fuchs, S.P., Mendes, D.E., Muniz, C.P. Ramos, Rakasz, E.G., Gao, G., Lifson, J.D., Desrosiers, R.C.

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OP 2.5 – 00048 Targeting the SIV reservoir with Alemtuzumab von Varco-Merth, B., Chaunzwa, M., Duell, D., Marenco, A., Docken, S., Smedley, J., Axthelm, M.K., Hansen, S.G., Davenport, M.P., Estes, J.D., Keele, B., Lifson, J.D., Lewin, S.R., Okoye, A.A., Picker, L.J.

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PP 4.1 – 00013 Vaccine-mediated induction of elite control-associated CD8+ cytotoxic T lymphocytes in Mamu-B08+ Indian rhesus macaques does not protect against intrarectal SIVmac23... von Rosen, B.C., Ricciardi, M.J., Pedreño-Lopez, Nuria, Voigt, T.B., Laurino, F.D., Louw, J.J., Yrizarry-Medina, A., Panayiotou, C., Newbolt, T., Weisgrau, K.L., Lifson, J.D., Desrosiers, R.C., Rakasz, E.G., Watkins, D.I.

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Infectious and Whole Inactivated Simian Immunodeficiency Viruses Interact Similarly with Primate Dendritic Cells (DCs): Differential Intracellular Fate of Virions in Mature and Imm... von Frank, I, Piatak, Jr, M, Stoessel, H, Romani, N, Bonnyay, D, Lifson, J D, Pope, M

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Evaluating latency reactivation synergies between the bromodomain inhibitor iBET-151 and the SMAC mimetic AZD5582 in SIV-infected macaques on ART von Okoye, A.A., Fukazawa, Y., Randall, B.E., Lum, R., Varco-Merth, B., Falcinelli, S.D., Smedley, J., Dunham, R., Lifson, J.D., Picker, L.J.

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B cell depletion alone or in combination with IL-15 or PD-1 blockade facilitates enhanced control of virus replication in SIV-infected rhesus macaques von Picker, L.J., Fukazawa, Y., Behrns, H., Randall, B.E., Varco-Merth, B., Park, H., Felber, B.K., Pavlakis, G.N., Lifson, J.D., Okoye, A.A.

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Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes in lymph nodes and reduces SHIV RNA von Pavlakis, G., Watson, D.C., Moysi, E., Valentin, A., Bergamaschi, C., Devasundaram, S., Fortis, S.P., Bear, J., Chertova, E., Bess, J., Sowder, R., Venzon, D.J., Deleage, C., Estes, J.D., Lifson, J.D., Petrovas, C., Felber, B.K.

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SIV persists in lymphoid tissues despite alemtuzumab-induced CD4+ T cell depletion von Okoye, A.A., Lewin, S.R., Xu, C.H., Vaidya, M., Duell, D.M., Brantley, W.B., Marenco, M.A., Fukazawa, Y., Park, H.M., Rasmussen, T.A., Lifson, J.D., Axthelm, M.K., Deeks, S.G., Picker, L.J.

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Clones of SIV-infected cells are present in spleen and lymph nodes in rhesus macaques von Hughes, S.H., Ferris, A.L., Del Prete, G.Q., Keele, B.F., Wu, X., Lifson, J.D.

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Vpx is required for dissemination and pathogenesis of SIVSM PBj: Evidence of macrophage-dependent viral amplification von Hirsch, V.M., Sharkey, M.E., Brown, C.R., Brichacek, B., Goldstein, S., Wakefield, J., Byrum, R., Elkins, W.R., Hahn, B.H., Lifson, J.D., Stevenson, M.

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Evaluation of aldrithiol-2-inactivated preparations of HIV type 1 subtypes A, B, and D as reagents to monitor T cell responses von RUTEBEMBERWA, A, BESS, J. W, ROBB, M, MAROVICH, M, LIFSON, J. D, COX, J. H, BROWN, B, ARROYO, M, ELLER, M, SLIKE, B, POLONIS, V, MCCUTCHAN, F, CURRIER, J. R, BIRX, D

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5.1 – 00136 Plasma SIVmacM clonotypes in rebound viremia correspond to those induced by AZD5582 during ART von Edara, V.V.C., Ukhueduan, B., Lampros, L., Fennessey, C.M., Lifson, J.D., Keele, B.F., Chahroudi, A.

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6.1 – 00142 Durable Viral Load Remission in SHIV-infected Macaques after Vectored Delivery of Monoclonal Antibodies von Martinez-Navio, J.M., Fuchs, S.P., Mondragon, P.G., Zabizhin, R., Mendes, D.E., Muniz, C.P.R., Weisgrau, K., Furlott, J., Alexander, E., Rakasz, E.G., Gao, G., Lifson, J.D., Desrosiers, R.C.

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Dual IL-10 and PD-1 blockade in SIVmac239 infected macaques promotes sustained virologic control in absence of ART von Strongin, Z, Ribeiro, S.P, Hoang, T.N, Nguyen, K, Harper, J, Estes, J.D, Micci, L, Lifson, J.D, Howell, B.J, Gorman, D, Hazuda, D.J, Paiardini, M, Sekaly, R-P

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PP5.3 – 00166 Treatment with AZD5582 + het-IL15 transiently disrupts the reservoir establishment in SIV-infected macaques von Statzu, M., Micali, C., Salinas, T.R. Wiche, Gurley, C., Healy, B., Carnathan, D.G., Felber, B.K., Pavlakis, G.N., Keele, B., Lifson, J.D., Laird, G.M., Margolis, D.M., Paiardini, M., Silvestri, G.

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Activation of HIV-1 specific CD4 and CD8 T cells by human dendritic cells: roles for cross-presentation and non-infectious HIV-1 virus von LARSSON, Marie, FONTENEAU, Jean-Francois, LIRVALL, Margareta, HASLETT, Patrick, LIFSON, Jeffrey D, BHARDWAJ, Nina

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Characterization of Peripheral and Mucosal Immune Responses In Rhesus Macaques on Long-Term Tenofovir and Emtricitabine Combination Antiretroviral Therapy von Jasny, Edith, Geer, Suzanne, Frank, Ines, Vagenas, Panagiotis, Aravantinou, Meropi, Salazar, Andres M, Lifson, Jeffrey D, Piatak, Michael, Gettie, Agegnehu, Blanchard, James L, Robbiani, Melissa

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High Levels of HIV-1 in Plasma During All Stages of Infection Determined by Competitive PCR von Piatak, M., Saag, M. S., Yang, L. C., Clark, S. J., Kappes, J. C., K.-C. Luk, Hahn, B. H., Shaw, G. M., Lifson, J. D.

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HIV-1 inhibits T cell proliferation by inducing indoleamine 2,3 dioxygenase in plasmacytoid dendritic von Boasso, A., J.P., Herbeuval, Hardy, A.W., S.A., Anderson, M.J., Dolan, J.D., Lifson, Fuchs, D., G.M., Shearer

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Non-cytolytic CD8 T-cell anti-HIV responses in primary HIV-1 infection von Mackewicz, E., Levy, J.A., Yang, L.C., Lifson, J.D.

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