Defining optimum lipophilicity and molecular weight ranges for drug candidates―Molecular weight dependent lower logD limits based on permeability von WARING, Michael J

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An analysis of the attrition of drug candidates from four major pharmaceutical companies von Waring, Michael J., Arrowsmith, John, Leach, Andrew R., Leeson, Paul D., Mandrell, Sam, Owen, Robert M., Pairaudeau, Garry, Pennie, William D., Pickett, Stephen D., Wang, Jibo, Wallace, Owen, Weir, Alex

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AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies von Rhyasen, Garrett W, Hattersley, Maureen M, Yao, Yi, Dulak, Austin, Wang, Wenxian, Petteruti, Philip, Dale, Ian L, Boiko, Scott, Cheung, Tony, Zhang, Jingwen, Wen, Shenghua, Castriotta, Lillian, Lawson, Deborah, Collins, Michael, Bao, Larry, Ahdesmaki, Miika J, Walker, Graeme, O'Connor, Greg, Yeh, Tammie C, Rabow, Alfred A, Dry, Jonathan R, Reimer, Corinne, Lyne, Paul, Mills, Gordon B, Fawell, Stephen E, Waring, Michael J, Zinda, Michael, Clark, Edwin, Chen, Huawei

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FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation von Wood, Daniel J, Lopez-Fernandez, J. Daniel, Knight, Leanne E, Al-Khawaldeh, Islam, Gai, Conghao, Lin, Shengying, Martin, Mathew P, Miller, Duncan C, Cano, Céline, Endicott, Jane A, Hardcastle, Ian R, Noble, Martin E. M, Waring, Michael J

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Potent and selective bivalent inhibitors of BET bromodomains von Waring, Michael J, Chen, Huawei, Rabow, Alfred A, Walker, Graeme, Bobby, Romel, Boiko, Scott, Bradbury, Rob H, Callis, Rowena, Clark, Edwin, Dale, Ian, Daniels, Danette L, Dulak, Austin, Flavell, Liz, Holdgate, Geoff, Jowitt, Thomas A, Kikhney, Alexey, McAlister, Mark, Méndez, Jacqui, Ogg, Derek, Patel, Joe, Petteruti, Philip, Robb, Graeme R, Robers, Matthew B, Saif, Sakina, Stratton, Natalie, Svergun, Dmitri I, Wang, Wenxian, Whittaker, David, Wilson, David M, Yao, Yi

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A quantitative assessment of hERG liability as a function of lipophilicity von Waring, Michael J., Johnstone, Craig

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Using diagrams to support the research process: examples from grounded theory von Buckley, Charles A, Waring, Michael J

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Pharmacological effectors of GRP78 chaperone in cancers von Bailly, Christian, Waring, Michael J.

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A genetically selected cyclic peptide inhibitor of BCL6 homodimerization von Osher, Eliot L., Castillo, Francisco, Elumalai, Nagarajan, Waring, Michael J., Pairaudeau, Garry, Tavassoli, Ali

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Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower log D limits based on permeability von Waring, Michael J.

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Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)‑4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3‑b]pyridazin-... von Bradbury, Robert H, Callis, Rowena, Carr, Gregory R, Chen, Huawei, Clark, Edwin, Feron, Lyman, Glossop, Steve, Graham, Mark A, Hattersley, Maureen, Jones, Chris, Lamont, Scott G, Ouvry, Gilles, Patel, Anil, Patel, Joe, Rabow, Alfred A, Roberts, Craig A, Stokes, Stephen, Stratton, Natalie, Walker, Graeme E, Ward, Lara, Whalley, David, Whittaker, David, Wrigley, Gail, Waring, Michael J

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Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding von Naidu, Mamta D, Agarwal, Rakhi, Pena, Louis A, Cunha, Luis, Mezei, Mihaly, Shen, Min, Wilson, 3rd, David M, Liu, Yuan, Sanchez, Zina, Chaudhary, Pankaj, Wilson, Samuel H, Waring, Michael J

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Practical application of ligand efficiency metrics in lead optimisation von Scott, James S., Waring, Michael J.

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CoII(Chromomycin)2 Complex Induces a Conformational Change of CCG Repeats from i-Motif to Base-Extruded DNA Duplex von Chen, Yu-Wen, Satange, Roshan, Wu, Pei-Ching, Jhan, Cyong-Ru, Chang, Chung-ke, Chung, Kuang-Ren, Waring, Michael, Lin, Sheng-Wei, Hsieh, Li-Ching, Hou, Ming-Hon

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Micellar Buchwald–Hartwig Coupling of Aryl and Heteroarylamines for the Synthesis of DNA-Encoded Libraries von Graham, Jessica S, Hunter, James H, Waring, Michael J

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Development of a Micellar-Promoted Heck Reaction for the Synthesis of DNA-Encoded Libraries von Stanway-Gordon, Harriet A., Odger, Jake A., Waring, Michael J.

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High Fidelity Suzuki–Miyaura Coupling for the Synthesis of DNA Encoded Libraries Enabled by Micelle Forming Surfactants von Hunter, James H, Prendergast, Lisa, Valente, Louis F, Madin, Andrew, Pairaudeau, Garry, Waring, Michael J

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On‐DNA Transfer Hydrogenolysis and Hydrogenation for the Synthesis of DNA‐Encoded Chemical Libraries von Stanway‐Gordon, Harriet A., Graham, Jessica S., Waring, Michael J.

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Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor von Finlay, M. Raymond V, Anderton, Mark, Ashton, Susan, Ballard, Peter, Bethel, Paul A, Box, Matthew R, Bradbury, Robert H, Brown, Simon J, Butterworth, Sam, Campbell, Andrew, Chorley, Christopher, Colclough, Nicola, Cross, Darren A. E, Currie, Gordon S, Grist, Matthew, Hassall, Lorraine, Hill, George B, James, Daniel, James, Michael, Kemmitt, Paul, Klinowska, Teresa, Lamont, Gillian, Lamont, Scott G, Martin, Nathaniel, McFarland, Heather L, Mellor, Martine J, Orme, Jonathon P, Perkins, David, Perkins, Paula, Richmond, Graham, Smith, Peter, Ward, Richard A, Waring, Michael J, Whittaker, David, Wells, Stuart, Wrigley, Gail L

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Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors von McAulay, Kirsten, Hoyt, Emily A, Thomas, Morgan, Schimpl, Marianne, Bodnarchuk, Michael S, Lewis, Hilary J, Barratt, Derek, Bhavsar, Deepa, Robinson, David M, Deery, Michael J, Ogg, Derek J, Bernardes, Gonçalo J L, Ward, Richard A, Waring, Michael J, Kettle, Jason G

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