High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations von Das, Kalyan, Bauman, Joseph D, Clark, Arthur D. Jr, Frenkel, Yulia V, Lewi, Paul J, Shatkin, Aaron J, Hughes, Stephen H, Arnold, Eddy

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The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward von Ortibus, Els, MD, Lopriore, Enrico, MD, PhD, Deprest, Jan, MD, PhD, Vandenbussche, Frank P., MD, PhD, Walther, Frans J., MD, PhD, Diemert, Anke, MD, Hecher, Kurt, MD, PhD, Lagae, Lieven, MD, PhD, De Cock, Paul, MD, PhD, Lewi, Paul J., PhD, Eng, Lewi, Liesbeth, MD, PhD

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Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase... von Das, Kalyan, Lewi, Paul J., Hughes, Stephen H., Arnold, Eddy

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In Search of a Novel Anti-HIV Drug:  Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile... von Janssen, Paul A. J, Lewi, Paul J, Arnold, Eddy, Daeyaert, Frits, de Jonge, Marc, Heeres, Jan, Koymans, Luc, Vinkers, Maarten, Guillemont, Jérôme, Pasquier, Elisabeth, Kukla, Mike, Ludovici, Don, Andries, Koen, de Béthune, Marie-Pierre, Pauwels, Rudi, Das, Kalyan, Clark, Art D, Frenkel, Yulia Volovik, Hughes, Stephen H, Medaer, Bart, De Knaep, Fons, Bohets, Hilde, De Clerck, Fred, Lampo, Ann, Williams, Peter, Stoffels, Paul

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Concentration and pH Dependent Aggregation of Hydrophobic Drug Molecules and Relevance to Oral Bioavailability von Frenkel, Yulia Volovik, Clark, Arthur D, Das, Kalyan, Wang, Yuh-Hwa, Lewi, Paul J, Janssen, Paul A. J, Arnold, Eddy

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SYNOPSIS:  SYNthesize and OPtimize System in Silico von Vinkers, H. Maarten, de Jonge, Marc R, Daeyaert, Frederik F. D, Heeres, Jan, Koymans, Lucien M. H, van Lenthe, Joop H, Lewi, Paul J, Timmerman, Henk, Van Aken, Koen, Janssen, Paul A. J

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Novel triazine dimers with potent antitrypanosomal activity von Venkatraj, Muthusamy, Salado, Irene G., Heeres, Jan, Joossens, Jurgen, Lewi, Paul J., Caljon, Guy, Maes, Louis, Van der Veken, Pieter, Augustyns, Koen

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Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Hi... von Das, Kalyan, Clark, Arthur D, Lewi, Paul J, Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Vinkers, H. Maarten, Daeyaert, Frederik, Ludovici, Donald W, Kukla, Michael J, De Corte, Bart, Kavash, Robert W, Ho, Chih Y, Ye, Hong, Lichtenstein, Mark. A, Andries, Koen, Pauwels, Rudi, de Béthune, Marie-Pierre, Boyer, Paul L, Clark, Patrick, Hughes, Stephen H, Janssen, Paul A. J, Arnold, Eddy

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Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1 von Grammen, Carolien, Ariën, Kevin K., Venkatraj, Muthusamy, Joossens, Jurgen, Van der Veken, Pieter, Heeres, Jan, Lewi, Paul J., Haenen, Steven, Augustyns, Koen, Vanham, Guido, Augustijns, Patrick, Brouwers, Joachim

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From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds von Venkatraj, Muthusamy, Ariën, Kevin K., Heeres, Jan, Joossens, Jurgen, Dirié, Bertrand, Lyssens, Sophie, Michiels, Johan, Cos, Paul, Lewi, Paul J., Vanham, Guido, Maes, Louis, Van der Veken, Pieter, Augustyns, Koen

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Synthesis of Novel Diarylpyrimidine Analogues and Their Antiviral Activity against Human Immunodeficiency Virus Type 1 von Guillemont, Jerome, Pasquier, Elisabeth, Palandjian, Patrice, Vernier, Daniel, Gaurrand, Sandrine, Lewi, Paul J, Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Daeyaert, Frits F. D, Vinkers, Maarten H, Arnold, Eddy, Das, Kalyan, Pauwels, Rudi, Andries, Koen, de Béthune, Marie-Pierre, Bettens, Eva, Hertogs, Kurt, Wigerinck, Piet, Timmerman, Philip, Janssen, Paul A. J

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The conductor and his orchestra von Lewi, Paul J.

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Diaryltriazine non-nucleoside reverse transcriptase inhibitors are potent candidates for pre-exposure prophylaxis in the prevention of sexual HIV transmission von Ariën, Kevin K, Venkatraj, Muthusamy, Michiels, Johan, Joossens, Jurgen, Vereecken, Katleen, Van der Veken, Pieter, Abdellati, Saïd, Cuylaerts, Vicky, Crucitti, Tania, Heyndrickx, Leo, Heeres, Jan, Augustyns, Koen, Lewi, Paul J, Vanham, Guido

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Stereotypy in schizophrenia von Morrens, Manuel, Hulstijn, Wouter, Lewi, Paul J., De Hert, Marc, Sabbe, Bernard G.C.

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Synthesis, evaluation and structure–activity relationships of triazine dimers as novel antiviral agents von Venkatraj, Muthusamy, Ariën, Kevin K., Heeres, Jan, Joossens, Jurgen, Messagie, Jonas, Michiels, Johan, Van der Veken, Pieter, Vanham, Guido, Lewi, Paul J., Augustyns, Koen

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Evolution of anti-HIV drug candidates. Part 3: diarylpyrimidine (DAPY) analogues von Ludovici, Donald W., De Corte, Bart L., Kukla, Michael J., Ye, Hong, Ho, Chih Y., Lichtenstein, Mark A., Kavash, Robert W., Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, Lewi, Paul J., Heeres, Jan, Koymans, Lucien M.H., de Jonge, Marc R., Van Aken, Koen J.A., Daeyaert, Frederik F.D., Das, Kalyan, Arnold, Edward, Janssen, Paul A.J.

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Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) von Venkatraj, Muthusamy, Ariën, Kevin K., Heeres, Jan, Dirié, Bertrand, Joossens, Jurgen, Van Goethem, Sebastiaan, Van der Veken, Pieter, Michiels, Johan, Vande Velde, Christophe M.L., Vanham, Guido, Lewi, Paul J., Augustyns, Koen

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Successful pharmaceutical discovery: Paul Janssen's concept of drug research von Lewi, Paul J., Smith, Adam

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Evolution of anti-HIV drug candidates. Part 2 : Diaryltriazine (DATA) analogues von LUDOVICI, Donald W, KAVASH, Robert W, MOEREELS, Henry E. L, HEERES, Jan, KOYMANS, Lucien M. H, DE JONGE, Marc R, VAN AKEN, Koen J. A, DAEYAERT, Frederik F. D, LEWI, Paul J, DAS, Kalyan, ARNOLD, Edward, JANSSEN, Paul A. J, KUKLA, Michael J, HO, Chih Y, HONG YE, DE CORTE, Bart L, ANDRIES, Koen, DE BETHUNE, Marie-Pierre, AZIJN, Hilde, PAUWELS, Rudi

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Graphical Exploration of Gene Expression Data: A Comparative Study of Three Multivariate Methods von Wouters, Luc, Göhlmann, Hinrich W., Bijnens, Luc, Kass, Stefan U., Molenberghs, Geert, Lewi, Paul J.

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