Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice von Hastings, Nicholas B, Wang, Xiaohai, Song, Lixin, Butts, Brent D, Grotz, Diane, Hargreaves, Richard, Fred Hess, J, Hong, Kwok-Lam Karen, Huang, Cathy Ruey-Ruey, Hyde, Lynn, Laverty, Maureen, Lee, Julie, Levitan, Diane, Lu, Sherry X, Maguire, Maureen, Mahadomrongkul, Veeravan, McEachern, Ernest J, Ouyang, Xuesong, Rosahl, Thomas W, Selnick, Harold, Stanton, Michaela, Terracina, Giuseppe, Vocadlo, David J, Wang, Ganfeng, Duffy, Joseph L, Parker, Eric M, Zhang, Lili

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Discovery of MK-8719, a Potent O‑GlcNAcase Inhibitor as a Potential Treatment for Tauopathies von Selnick, Harold G, Hess, J. Fred, Tang, Cuyue, Liu, Kun, Schachter, Joel B, Ballard, Jeanine E, Marcus, Jacob, Klein, Daniel J, Wang, Xiaohai, Pearson, Michelle, Savage, Mary J, Kaul, Ramesh, Li, Tong-Shuang, Vocadlo, David J, Zhou, Yuanxi, Zhu, Yongbao, Mu, Changwei, Wang, Yaode, Wei, Zhongyong, Bai, Chang, Duffy, Joseph L, McEachern, Ernest J

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Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy von Wang, Xiaohai, Smith, Karen, Pearson, Michelle, Hughes, Anna, Cosden, Mali L, Marcus, Jacob, Hess, J Fred, Savage, Mary J, Rosahl, Thomas, Smith, Sean M, Schachter, Joel B, Uslaner, Jason M

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Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6 von Holmen, Sheri L, Giambernardi, Troy A, Zylstra, Cassandra R, Buckner‐Berghuis, Bree D, Resau, James H, Hess, J Fred, Glatt, Vaida, Bouxsein, Mary L, Ai, Minrong, Warman, Matthew L, Williams, Bart O

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Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology von Song, Lixin, Lu, Sherry X, Ouyang, Xuesong, Melchor, Jerry, Lee, Julie, Terracina, Giuseppe, Wang, Xiaohai, Hyde, Lynn, Hess, J Fred, Parker, Eric M, Zhang, Lili

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Allosteric Modulation of Group III Metabotropic Glutamate Receptor 4: A Potential Approach to Parkinson's Disease Treatment von Marino, Michael J., Williams, David L., O'Brien, Julie A., Valenti, Ornella, McDonald, Terrence P., Clements, Michelle K., Wang, Ruiping, DiLella, Anthony G., Hess, J. Fred, Kinney, Gene G., Conn, P. Jeffrey

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Attenuation of scratch‐induced reactive astrogliosis by novel EphA4 kinase inhibitors von Parmentier‐Batteur, Sophie, Finger, Eleftheria N., Krishnan, Raghu, Rajapakse, Hemaka A., Sanders, John M., Kandpal, Geeta, Zhu, Hong, Moore, Keith P., Regan, Christopher P., Sharma, Sujata, Hess, J. Fred, Williams, Theresa M., Reynolds, Ian J., Vacca, Joseph P., Mark, Robert J., Nantermet, Philippe G.

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MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy von Wang, Xiaohai, Li, Wenping, Marcus, Jacob, Pearson, Michelle, Song, Lixin, Smith, Karen, Terracina, Giuseppe, Lee, Julie, Hong, Kwok-Lam Karen, Lu, Sherry X., Hyde, Lynn, Chen, Shu-Cheng, Kinsley, David, Melchor, Jerry P., Rubins, Daniel J., Meng, Xiangjun, Hostetler, Eric, Sur, Cyrille, Zhang, Lili, Schachter, Joel B., Hess, J. Fred, Selnick, Harold G., Vocadlo, David J., McEachern, Ernest J., Uslaner, Jason M., Duffy, Joseph L., Smith, Sean M.

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Discovery of 6‑(Fluoro-18 F)‑3-(1H‑pyrrolo[2,3‑c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofib... von Walji, Abbas M, Hostetler, Eric D, Selnick, Harold, Zeng, Zhizhen, Miller, Patricia, Bennacef, Idriss, Salinas, Cristian, Connolly, Brett, Gantert, Liza, Holahan, Marie, O’Malley, Stacey, Purcell, Mona, Riffel, Kerry, Li, Jing, Balsells, Jaume, OBrien, Julie A, Melquist, Stacey, Soriano, Aileen, Zhang, Xiaoping, Ogawa, Aimie, Xu, Serena, Joshi, Elizabeth, Della Rocca, Joseph, Hess, Fred J, Schachter, Joel, Hesk, David, Schenk, David, Struyk, Arie, Babaoglu, Kerim, Lohith, Talakad G, Wang, Yaode, Yang, Kun, Fu, Jianmin, Evelhoch, Jeffrey L, Coleman, Paul J

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Genome-Wide Microarray Analysis of the Differential Neuroprotective Effects of Antioxidants in Neuroblastoma Cells Overexpressing the Familial Parkinson’s Disease α-Synuclein A53T... von Ma, Lei, Cao, Tracy T., Kandpal, Geeta, Warren, Lee, Fred Hess, J., Seabrook, Guy R., Ray, William J.

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The NOD Idd9 Genetic Interval Influences the Pathogenicity of Insulitis and Contains Molecular Variants of Cd30, Tnfr2, and Cd137 von Lyons, Paul A, Hancock, Wayne W, Denny, Paul, Lord, Christopher J, Hill, Natasha J, Armitage, Nicola, Siegmund, Thorsten, Todd, John A, Phillips, Michael S, Hess, J Fred, Chen, Shiow-Ling, Fischer, Paul A, Peterson, Laurence B, Wicker, Linda S

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Discovery of a Potent, Non-peptide Bradykinin B1 Receptor Antagonist von Su, Dai-Shi, Markowitz, M. Kristine, DiPardo, Robert M, Murphy, Kathy L, Harrell, C. Meacham, O'Malley, Stacy S, Ransom, Richard W, Chang, Raymond S. L, Ha, Sookhee, Hess, Fred J, Pettibone, Douglas J, Mason, Glenn S, Boyce, Susan, Freidinger, Roger M, Bock, Mark G

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Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene von Twells, Rebecca C J, Mein, Charles A, Phillips, Michael S, Hess, J Fred, Veijola, Riitta, Gilbey, Matthew, Bright, Matthew, Metzker, Michael, Lie, Benedicte A, Kingsnorth, Amanda, Gregory, Edward, Nakagawa, Yusuke, Snook, Hywel, Wang, William Y S, Masters, Jennifer, Johnson, Gillian, Eaves, Iain, Howson, Joanna M M, Clayton, David, Cordell, Heather J, Nutland, Sarah, Rance, Helen, Carr, Philippa, Todd, John A

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Leptin receptor missense mutation in the fatty Zucker rat von Phillips, Michael S, Liu, Qingyun, Hammond, Holly A, Dugan, Valarie, Hey, Patricia J, Caskey, C. Thomas, Hess, J. Fred

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Conserved Aspartate Residues and Phosphorylation in Signal Transduction by the Chemotaxis Protein CheY von Bourret, Robert B., Hess, J. Fred, Simon, Melvin I.

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Increased nuclear factor‐erythroid 2 p45‐related factor 2 activity protects SH‐SY5Y cells against oxidative damage von Cao, Tracy T., Ma, Lei, Kandpal, Geeta, Warren, Lee, Hess, J. Fred, Seabrook, Guy R.

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Development of Orally Bioavailable and CNS Penetrant Biphenylaminocyclopropane Carboxamide Bradykinin B1 Receptor Antagonists von Kuduk, Scott D., Di Marco, Christina N., Chang, Ronald K., Wood, Michael R., Schirripa, Kathy M., Kim, June J., Wai, Jenny M. C., DiPardo, Robert M., Murphy, Kathy L., Ransom, Richard W., Harrell, C. Meacham, Reiss, Duane R., Holahan, Marie A., Cook, Jacquelynn, Hess, J. Fred, Sain, Nova, Urban, Mark O., Tang, Cuyue, Prueksaritanont, Thomayant, Pettibone, Douglas J., Bock, Mark G.

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Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor von Hess, J. Fred, Borkowski, Joseph A., Young, Gretchen S., Strader, Catherine D., Ransom, Richard W.

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Targeted Disruption of a B2 Bradykinin Receptor Gene in Mice Eliminates Bradykinin Action in Smooth Muscle and Neurons von Borkowski, Joseph A., Ransom, Richard W., Seabrook, Guy R., Trumbauer, Myrna, Chen, Howard, Hill, Ray G., Strader, Catherine D., Hess, J. Fred

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Identification of the Critical Residues of Bradykinin Receptor B1 for Interaction with the Kinins Guided by Site-Directed Mutagenesis and Molecular Modeling von Ha, Sookhee N, Hey, Pat J, Ransom, Rick W, Bock, Mark G, Su, Dai-Shi, Murphy, Kathryn L, Chang, Ray, Chen, Tsing-Bau, Pettibone, Douglas, Hess, J. Fred

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