HNRNPH1 destabilizes the G-quadruplex structures formed by G-rich RNA sequences that regulate the alternative splicing of an oncogenic fusion transcript von Vo, Tam, Brownmiller, Tayvia, Hall, Katherine, Jones, Tamara L, Choudhari, Sulbha, Grammatikakis, Ioannis, Ludwig, Katelyn R, Caplen, Natasha J

Volltext

Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA von Mackiewicz, Mark, Huppi, Konrad, Pitt, Jason J., Dorsey, Tiffany H., Ambs, Stefan, Caplen, Natasha J.

Volltext

Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response von Zhang, Yong-Wei, Jones, Tamara L., Martin, Scott E., Caplen, Natasha J., Pommier, Yves

Volltext

Specific Inhibition of Gene Expression by Small Double-Stranded RNAs in Invertebrate and Vertebrate Systems von Caplen, Natasha J., Parrish, Susan, Imani, Farhad, Fire, Andrew, Morgan, Richard A.

Volltext

Short Interfering RNAs Can Induce Unexpected and Divergent Changes in the Levels of Untargeted Proteins in Mammalian Cells von Scacheri, Peter C., Rozenblatt-Rosen, Orit, Caplen, Natasha J., Wolfsberg, Tyra G., Umayam, Lowell, Lee, Jeffrey C., Hughes, Christina M., Shanmugam, Kalai Selvi, Bhattacharjee, Arindam, Meyerson, Matthew, Collins, Francis S., Vogelstein, Bert

Volltext

Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome von Murrow, Lyndsay M, Garimella, Sireesha V, Jones, Tamara L, Caplen, Natasha J, Lipkowitz, Stanley

Volltext

Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation von Tandle, Anita T, Kramp, Tamalee, Kil, Whoon J, Halthore, Aditya, Gehlhaus, Kristen, Shankavaram, Uma, Tofilon, Philip J, Caplen, Natasha J, Camphausen, Kevin

Volltext

Functional Genomic Screening Reveals Splicing of the EWS-FLI1 Fusion Transcript as a Vulnerability in Ewing Sarcoma von Grohar, Patrick J., Kim, Suntae, Rangel Rivera, Guillermo O., Sen, Nirmalya, Haddock, Sara, Harlow, Matt L., Maloney, Nichole K., Zhu, Jack, O’Neill, Maura, Jones, Tamara L., Huppi, Konrad, Grandin, Magdalena, Gehlhaus, Kristen, Klumpp-Thomas, Carleen A., Buehler, Eugen, Helman, Lee J., Martin, Scott E., Caplen, Natasha J.

Volltext

The Identification of MicroRNAs in a Genomically Unstable Region of Human Chromosome 8q24 von Huppi, Konrad, Volfovsky, Natalia, Runfola, Timothy, Jones, Tamara L, Mackiewicz, Mark, Martin, Scott E, Mushinski, J Frederic, Stephens, Robert, Caplen, Natasha J

Volltext

Pvt1-encoded microRNAs in oncogenesis von Beck-Engeser, Gabriele B, Lum, Amy M, Huppi, Konrad, Caplen, Natasha J, Wang, Bruce B, Wabl, Matthias

Volltext

The HNRNPF/H RNA binding proteins and disease von Brownmiller, Tayvia, Caplen, Natasha J

Volltext

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival von Lee, Chih-Shia, Lee, Liam C., Yuan, Tina L., Chakka, Sirisha, Fellmann, Christof, Lowe, Scott W., Caplen, Natasha J., McCormick, Frank, Luo, Ji

Volltext

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer von LUDWIG, Joseph A, SZAKACS, Gergely, GOTTESMAN, Michael M, MARTIN, Scott E, CHU, Benjamin F, CARDARELLI, Carol, SAUNA, Zuben E, CAPLEN, Natasha J, FALES, Henry M, AMBUDKAR, Suresh V, WEINSTEIN, John N

Volltext

Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma von Graham, Garrett T, Selvanathan, Saravana P, Zöllner, Stefan K, Stahl, Emily, Shlien, Adam, Caplen, Natasha J, Üren, Aykut, Toretsky, Jeffrey A

Volltext

Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(gua... von Jobson, Andrew G, Lountos, George T, Lorenzi, Philip L, Llamas, Jenny, Connelly, John, Cerna, David, Tropea, Joseph E, Onda, Akikazu, Zoppoli, Gabriele, Kondapaka, Sudhir, Zhang, Guangtao, Caplen, Natasha J, Cardellina, 2nd, John H, Yoo, Stephen S, Monks, Anne, Self, Christopher, Waugh, David S, Shoemaker, Robert H, Pommier, Yves

Volltext

p53-dependent Induction of PVT1 and miR-1204 von Barsotti, Anthony M., Beckerman, Rachel, Laptenko, Oleg, Huppi, Konrad, Caplen, Natasha J., Prives, Carol

Volltext

Loss-of-function RNAi screens in breast cancer cells identify AURKB, PLK1, PIK3R1, MAPK12, PRKD2 , and PTK6 as sensitizing targets of rapamycin activity von Ou, Oliver, Huppi, Konrad, Chakka, Sirisha, Gehlhaus, Kristen, Dubois, Wendy, Patel, Jyoti, Chen, Jinqiu, Mackiewicz, Mark, Jones, Tamara L, Pitt, Jason J, Martin, Scott E, Goldsmith, Paul, Simmons, John K, Mock, Beverly A, Caplen, Natasha J

Volltext

RNAi microarray analysis in cultured mammalian cells von Mousses, Spyro, Caplen, Natasha J, Cornelison, Robert, Weaver, Don, Basik, Mark, Hautaniemi, Sampsa, Elkahloun, Abdel G, Lotufo, Roberto A, Choudary, Ashish, Dougherty, Edward R, Suh, Ed, Kallioniemi, Olli

Volltext

Asparagine synthetase as a causal, predictive biomarker for l-asparaginase activity in ovarian cancer cells von Lorenzi, Philip L, Reinhold, William C, Rudelius, Martina, Gunsior, Michele, Shankavaram, Uma, Bussey, Kimberly J, Scherf, Uwe, Eichler, Gabriel S, Martin, Scott E, Chin, Koei, Gray, Joe W, Kohn, Elise C, Horak, Ivan D, Von Hoff, Daniel D, Raffeld, Mark, Goldsmith, Paul K, Caplen, Natasha J, Weinstein, John N

Volltext

Fusion transcripts: Unexploited vulnerabilities in cancer? von Neckles, Carla, Sundara Rajan, Soumya, Caplen, Natasha J.

Volltext