Effects of chronotropic incompetence on exercise capacity in people with heart failure versus age-matched controls von NA, Smart, H, Clark, P, Brubaker, KK, Witte, H, Jamil, J, Gierula, HC, Patel, MJ, Pearson

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154 Patients receiving standard pacemaker generator replacements frequently have impaired left ventricular function and exercise intolerance, related to the percentage of right ven... von Begg, G A, Gierula, J, Waldron, Z L, Witte, K K

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Defining patterns of comorbidity accrual before and after the diagnosis of heart failure von Macgowan, H, Brown, O, Walker, A, Mcginlay, M, Gierula, J, Paton, M, Straw, S, Witte, K, Drozd, M, Kearney, M, Cubbon, R

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Left ventricular dysfunction, heart failure, and mortality risk factors in de novo pacemaker recipients and those requiring pacemaker generator replacement von Abdul Samad, N H, Lowry, J E, Cole, C A, Straw, S, Gierula, J, Witte, K K, Paton, M F

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1724 Age is just a number: Cardiac resynchronisation therapy in older patients has comparable outcomes to those that are younger von Safdar, N Z, Kamalathasan, S, Gupta, A, Wren, J, Bird, R, Papp, D, Latto, R, Ahmed, A, Palin, V, Gierula, J, Witte, K K, Straw, S

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Cardiac contractility index, a novel biomarker of incident heart failure amongst people with normal left ventricular ejection fraction in the UK Biobank von Cole, C, Straw, S, Drozd, M, Conning-Rowland, M, Kamalathasan, S, Lowry, J, Paton, M F, Slater, T A, Levelt, E, Kearney, M T, Witte, K K, Cubbon, R M, Gierula, J, Brown, O I

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Digoxin reduces senescence and restores dysfunctional endothelial-subcutaneous adipocyte cross-talk and dysregulated glucose homeostasis in patients with type 2 diabetes mellitus von Brown, O I, Bridge, K I, Straw, S, Luk, C, Makava, N, Tayebjee, M, Saunderson, C E D, Bruns, A F, Drozd, M, Gierula, J, Wheatcroft, S B, Witte, K K, Cubbon, R M, Kearney, M T

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106 CHF patients are vitamin D deficient and hyperparathyroid, with levels of each related to markers of severity von Begg, G A, Kearney, L, Wheatcroft, A C, Byrom, R, Barnes, S, Gierula, J, Barth, J, Cubbon, R, Kearney, M T, Witte, K K

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The diabetic myocardial transcriptome reveals Erbb3 as a novel biomarker of incident heart failure von Conning-Rowland, M, Giannoudi, M, Drozd, M, Brown, O, Yuldasheva, N, Cheng, C, Meakin, P, Straw, S, Gierula, J, Ajjan, R, Kearney, M, Levelt, E, Roberts, L, Griffin, K, Cubbon, R

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The relationship between diabetes, obesity and cardiovascular disease phenotypes: a UK Biobank cohort study von Brown, O, Drozd, M, Mcgowan, H, Giannoudi, M, Conning-Rowland, M, Gierula, J, Straw, S, Wheatcroft, S B, Paradine, K, Roberts, L D, Levelt, E, Ajjan, R, Griffin, K J, Kearney, M T, Cubbon, R M

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Partial normalisation of cardiac mechanics with active CRT in patients with chronic failure: a novel application of 3.0T CMR von Koshy, A, Gierula, J, Paton, M, Swoboda, P, Toms, A.G, Saunderson, C, Shelley, D, Broadbent, D, Plein, S, Kearney, M.T, Witte, K.K

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P1236Revealing cardiac mechanics with CMR whilst CRT is active: the first step von Koshy, A, Gierula, J, Paton, M, Swoboda, P, Toms, A, Saunderson, C, Shelley, D, Plein, D, Cubbon, R, Kearney, M, Witte, K

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P3240Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure von Witte, K.K., Cubbon, R.M., Lowry, J.E., Drozd, M., Hall, M., Gierula, J., Paton, M.F., Byrom, R., Kearney, L.C., Barth, J.H., Cairns, D.A., Kearney, M.T.

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Detrimental immediate and long-term clinical effects of right ventricular pacing in patients with myocardial fibrosis von Saunderson, C, Paton, MF, Brown, LAE, Gierula, J, Chew, PG, Das, A, Sengupta, A, Craven, TP, Chowdhary, A, Levelt, E, Dall"armellina, E, Witte, KK, Greenwood, JP, Plein, S, Swoboda, PP

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492Prevalence and distribution of cardiac fibrosis in patients with atrioventricular block undergoing pacemaker implantation von Saunderson, C, Paton, M F, Gierula, J, Brown, L A E, Chew, P G, Das, A, Craven, T P, Jain, M, Levelt, E, Dall"armellina, E, Witte, K K, Greenwood, J P, Plein, S, Swoboda, P P

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Optimising pacemaker therapy using multi-point pacing (the OPT-MPP Study) von Lowry, JE, Straw, S, Cole, CA, Paton, M F, Kearney, M T, Witte, K K, Gierula, J

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Cardiac resynchronization therapy in pacemaker-dependent patients with left ventricular dysfunction von Gierula, John, Cubbon, Richard M, Jamil, Haqeel A, Byrom, Rowenna, Baxter, Paul D, Pavitt, Sue, Gilthorpe, Mark S, Hewison, Jenny, Kearney, Mark T, Witte, Klaus K A

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80 The prognostic value of cardiovascular magnetic resonance in aborted sudden cardiac death von Swoboda, P. P., Kidambi, A., Gierula, J., Witte, K. K., Greenwood, J. P., Plein, S.

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Long-term adverse sequelae of left ventricular leads in the context of cardiac resynchronisation therapy von Hammond, C, Nadarajah, R, Ali, N, Tan, F, Burnet, N, Cole, C, Paton, M, Cubbon, R, Kearney, M, Gierula, J, Witte, K, Patel, P

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Prevalence and distribution of cardiac fibrosis in patients with atrioventricular block undergoing pacemaker implantation von Saunderson, CED, Paton, M F, Gierula, J, Brown, LAE, Greenwood, J P, Koshy, A, Craven, T P, Chew, P G, Das, A, Levelt, E, E Dall’Armellina, Witte, K K, Plein, S, Swoboda, P P

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