1468P cGAS-driven inflammation in chromosomally unstable oesophagogastric adenocarcinoma von Parkes, E.E., Erdal, E., Shah, P., Clark, R., Clarke, S., Carter, A., Foijer, F., Hammond, E., Izar, B., Beernaert, B.

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LB939 Novel recommendations to minimize cSCC risk in SOTR von Kwinta, B.D., Khan, S., Carvajal, R., Izar, B., Queen, D., Garcia-Saleem, T., Geskin, L.

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750P Phase I safety and efficacy of brenetafusp, a PRAME × CD3 ImmTAC T cell engager, in platinum resistant ovarian cancer (PROC) von Friedman, C., De Burgh Williams, A., Lopez, J.S., Ouali, K., Middleton, M.R., Thistlethwaite, F., Hamid, O., Izar, B., Garcia, V. Moreno, Johnson, M.L., Davar, D., Martin-Liberal, J., Roxburgh, P., Moore, K.N., Olson, D., Rottey, S., Kirk, P.B., Yuan, Y., Marshall, S., Yeku, O.

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728O Results from phase I dose escalation of IMC-F106C, the first PRAME × CD3 ImmTAC bispecific protein in solid tumors von Hamid, O., Sato, T., Davar, D., Callahan, M.K., Thistlethwaite, F., Aljumaily, R., Johnson, M.L., Arkenau, H-T., Ileana Dumbrava, E.E., Izar, B., Chen, H.A., Marshall, S., Yuan, Y., Deo, M., Stanhope, S., Collins, L., Mundy, R., Abdullah, S.E., Lopez, J.S.

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037 A systems immunology approach to classify melanoma tumor infiltrating lymphocytes (TILs) informs and models overall survival von Jaiswal, A., Verma, A., Dannenfelser, R., Melssen, M., Tirosh, I., Izar, B., Kim, T., Nirschl, C., Devi, S., Olson, W., Slingluff, C., Engelhard, V., Garraway, L., Regev, A., Yoon, C., Troyanskaya, O., Elemento, O., Suarez-Farinas, M., Anandasabapathy, N.

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microRNA response to Listeria monocytogenes infection in epithelial cells von Izar, Benjamin, Mannala, Gopala Krishna, Mraheil, Mobarak Abu, Chakraborty, Trinad, Hain, Torsten

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72P Concurrent local therapy (CLT) extends clinical benefit of tebentafusp (tebe) in metastatic uveal melanoma (mUM) patients (pts) von Lim, T., Montazeri, K., Desilets, A., Shoushtari, A.N., Seedor, R., Orloff, M., Sato, T., Caplan, M., El-Ashmawy, M., Izar, B., Khan, S., Carvajal, R.D., Mehmi, I., Hamid, O., Sullivan, R.

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Social cliques in male northern muriquis Brachyteles hypoxanthus von Tokuda, Marcos, Boubli, Jean P., Izar, Patrícia, Strier, Karen B.

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062 Human melanoma TILs share phenotypic and transcriptional properties with tissue resident memory T cells von Devi, K., Melssen, M., Tirosh, I., Izar, B., Olson, W., Engelhard, V., Slingluff, C., Regev, A., Garraway, L., Kupper, T., Yoon, C., Suarez-Farinas, M., Anandasabapathy, N.

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065 Highly conserved tissue immune signatures are co-opted in cancer von Suarez-Farinas, M., Devi, K., Dannenfelser, R., Izar, B., Prakadan, S., Zhu, Q., Yoon, C., Regev, A., Garraway, L., Shalek, A., Troyansakaya, O., Anandasabapathy, N.

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Identification and Role of Regulatory Non-Coding RNAs in Listeria monocytogenes von Izar, Benjamin, Mraheil, Mobarak Abu, Hain, Torsten

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130P COM701 ± nivolumab: Preliminary results of antitumor activity from a phase I study in patients with metastatic NSCLC who have received prior PD-1/PD-L1 inhibitor von Sullivan, R.J., Sharma, M.R., Vaena, D., Hamilton, E., Izar, B., Rasco, D., Gainor, J., D. Shepard, Papadopoulos, K., Dumbrava, E.E., Adewoye, H.H., Ferre, P.J., Ophir, E., Patel, M., Patnaik, A., Chmielowski, B.

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159P COM701 in combination with nivolumab demonstrates preliminary antitumor activity in patients with platinum-resistant epithelial ovarian cancer von Yeku, O., D. Shepard, Patel, M., Fleming, G., Vaena, D., Rasco, D., Chmielowski, B., Sharma, M.R., Hamilton, E., Sullivan, R.J., Papadopoulos, K., Izar, B., Cojocaru, G., Ophir, E., Ferre, P.J., Dumbrava, E.E.

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158P Triple blockade of the DNAM-axis with COM701 + BMS-986207 + nivolumab demonstrates preliminary antitumor activity in patients with platinum-resistant OVCA von Moroney, J., Yeku, O., Fleming, G., Emens, L.A., Vaena, D., Dumbrava, E.E., Rasco, D., Sharma, M.R., Papadopoulos, K., Patnaik, A., Sullivan, R.J., Adewoye, H.H., Ophir, E., Cojocaru, G., Ferre, P.J., Izar, B., Gaillard, S.

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E-023 Progressive occlusion in aneurysms treated with stent assisted coiling: flow diversion? von Izar, B, Rai, A, Carpenter, J, Raghuram, K

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P-008 Collateral blood supply as predictor of good clinical outcome in patients undergoing endovascular therapy for acute ischemic stroke von Rai, A, Hobbs, G, Meadows, J, Izar, B, Carpenter, J, Raghuram, K

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Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis von Li, J, Duran, MA, Dhanota, N, Chatila, WK, Bettigole, SE, Kwon, J, Sriram, RK, Humphries, MP, Salto-Tellez, M, James, JA, Hanna, MG, Melms, JC, Vallabhaneni, S, Litchfield, K, Usaite, I, Biswas, D, Bareja, R, Li, HW, Martin, ML, Dorsaint, P, Cavallo, J-A, Li, P, Pauli, C, Gottesdiener, L, DiPardo, BJ, Hollmann, TJ, Merghoub, T, Wen, HY, Reis-Filho, JS, Riaz, N, Su, S-SM, Kalbasi, A, Vasan, N, Powell, SN, Wolchok, JD, Elemento, O, Swanton, C, Shoushtari, AN, Parkes, EE, Izar, B, Bakhoum, SF

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A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors von Slyper, M, Porter, CBM, Ashenberg, O, Waldman, J, Drokhlyansky, E, Wakiro, I, Smillie, C, Smith-Rosario, G, Wu, J, Dionne, D, Vigneau, S, Jané-Valbuena, J, Tickle, TL, Napolitano, S, Su, M-J, Patel, AG, Karlstrom, A, Gritsch, S, Nomura, M, Waghray, A, Gohil, SH, Tsankov, AM, Jerby-Arnon, L, Cohen, O, Klughammer, J, Rosen, Y, Gould, J, Nguyen, L, Hofree, M, Tramontozzi, PJ, Li, B, Wu, CJ, Izar, B, Haq, R, Hodi, FS, Yoon, CH, Hata, AN, Baker, SJ, Suvà, ML, Bueno, R, Stover, EH, Clay, MR, Dyer, MA, Collins, NB, Matulonis, UA, Wagle, N, Johnson, BE, Rotem, A, Rozenblatt-Rosen, O, Regev, A

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Capuchin monkey tool use: Overview and implications von Ottoni, Eduardo B., Izar, Patrícia

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Imbalance between endothelial progenitors cells and microparticles in HIV-infected patients naive for antiretroviral therapy von DA SILVA, Erika F. R, FONSECA, Francisco A. H, FRANCA, Carolina N, FERREIRA, Paulo R. A, IZAR, Maria C. O, SALOMAO, Reinaldo, CAMARGO, Luciano M, TENORE, Simone B, LEWI, David S

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