Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancer von Galhenage, Pamoda, Zhou, Yunlan, Perry, Erica, Loc, Brenda, Fietz, Kelly, Iyer, Sonia, Reinhardt, Ferenc, Da Silva, Tiego, Botchkarev, Vladimir, Chen, Jie, Crum, Christopher P., Weinberg, Robert A., Pathania, Shailja

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Role of SHIP1 in cancer and mucosal inflammation von Fernandes, Sandra, Iyer, Sonia, Kerr, William G.

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The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment von Hardaker, Elizabeth L., Sanseviero, Emilio, Karmokar, Ankur, Taylor, Devon, Milo, Marta, Michaloglou, Chrysis, Hughes, Adina, Mai, Mimi, King, Matthew, Solanki, Anisha, Magiera, Lukasz, Miragaia, Ricardo, Kar, Gozde, Standifer, Nathan, Surace, Michael, Gill, Shaan, Peter, Alison, Talbot, Sara, Tohumeken, Sehmus, Fryer, Henderson, Mostafa, Ali, Mulgrew, Kathy, Lam, Carolyn, Hoffmann, Scott, Sutton, Daniel, Carnevalli, Larissa, Calero-Nieto, Fernando J., Jones, Gemma N., Pierce, Andrew J., Wilson, Zena, Campbell, David, Nyoni, Lynet, Martins, Carla P., Baker, Tamara, Serrano de Almeida, Gilberto, Ramlaoui, Zainab, Bidar, Abdel, Phillips, Benjamin, Boland, Joseph, Iyer, Sonia, Barrett, J. Carl, Loembé, Arsene-Bienvenu, Fuchs, Serge Y., Duvvuri, Umamaheswar, Lou, Pei-Jen, Nance, Melonie A., Gomez Roca, Carlos Alberto, Cadogan, Elaine, Critichlow, Susan E., Fawell, Steven, Cobbold, Mark, Dean, Emma, Valge-Archer, Viia, Lau, Alan, Gabrilovich, Dmitry I., Barry, Simon T.

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SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells von Brooks, Robert, Fuhler, Gwenny M, Iyer, Sonia, Smith, Michelle J, Park, Mi-Young, Paraiso, Kim H. T, Engelman, Robert W, Kerr, William G

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Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer von Fuhler, Gwenny M, Brooks, Robert, Toms, Bonnie, Iyer, Sonia, Gengo, Elizabeth A, Park, Mi-Young, Gumbleton, Matthew, Viernes, Dennis R, Chisholm, John D, Kerr, William G

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Inaugurating High-Throughput Profiling of Extracellular Vesicles for Earlier Ovarian Cancer Detection von Jo, Ala, Green, Allen, Medina, Jamie E, Iyer, Sonia, Ohman, Anders W, McCarthy, Eric T, Reinhardt, Ferenc, Gerton, Thomas, Demehin, Daniel, Mishra, Ranjan, Kolin, David L, Zheng, Hui, Cheon, Jinwoo, Crum, Christopher P, Weinberg, Robert A, Rueda, Bo R, Castro, Cesar M, Dinulescu, Daniela M, Lee, Hakho

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Layer‐by‐layer interleukin‐12 nanoparticles drive a safe and effective response in ovarian tumors von Barberio, Antonio E., Smith, Sean G., Pires, Ivan S., Iyer, Sonia, Reinhardt, Ferenc, Melo, Mariane B., Suh, Heikyung, Weinberg, Robert A., Irvine, Darrell J., Hammond, Paula T.

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886 In vitro study of the effects of ceralasertib (AZD6738) on the tumor microenvironment cell populations von Vence, Luis, Rayanki, Radhika, Deng, Tao, Moustafa, Mohamed, Iyer, Sonia, Milo, Marta, Greenlees, Lydia, Arbitman, Steve, Lambert, Arthur, Fabbri, Giulia, Cimbro, Raffaello, Jones, Gemma, Palmer, Douglas C, McCoon, Patricia

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695 Efficacy and safety of trastuzumab deruxtecan (T-DXd) with durvalumab in patients with non-small cell lung cancer (HER2 altered NSCLC) who progressed on anti-PD1/PD-L1 therapy... von Cheema, Parneet, Hartl, Sylvia, Koczywas, Marianna, Hochmair, Maximilian, Shepherd, Frances A, Chu, Quincy, Galletti, Giuseppe, Gustavson, Mark, Iyer, Sonia, Carl Barrett, J, Evans, Brent, Kumar, Rakesh, Cosaert, Jan, Park, Keunchil, Heymach, John V

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Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunothrapy von Iyer, Sonia, Zhang, Shuang, Yucel, Simge, Horn, Heiko, Smith, Sean G., Reinhardt, Ferenc, Hoefsmit, Esmee, Assatova, Bimarzhan, Casado, Julia, Meinsohn, Marie-Charlotte, Barrasa, M. Inmaculada, Bell, George W., Perez-Villatoro, Fernando, Huhtinen, Kaisa, Hynninen, Johanna, Oikkonen, Jaana, Galhenage, Pamoda M., Pathania, Shailja, Hammond, Paula T., Neel, Benjamin G., Farkkila, Anniina, Pepin, David, Weinberg, Robert A.

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Abstract PR12: Genetic aberrations dictate distinct tumor immune landscape and chemosensitivity in HGSOC von Zhang, Shuang, Iyer, Sonia, Ran, Hao, Wei, Wei, Weinberg, Robert A., Neel, Benjamin G.

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Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer von Zhang, Shuang, Iyer, Sonia, Ran, Hao, Dolgalev, Igor, Gu, Shengqing, Wei, Wei, Foster, Connor J. R., Loomis, Cynthia A., Olvera, Narciso, Dao, Fanny, Levine, Douglas A., Weinberg, Robert A., Neel, Benjamin G.

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Abstract PR05: Development of new immune therapy combinations for ovarian cancer using genetically defined organoid platform von Zhang, Shuang, Iyer, Sonia, Ran, Hao, wei, Wei, Weinberg, Robert A, Neel, Benjamin G

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Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial von Besse, Benjamin, Pons-Tostivint, Elvire, Park, Keunchil, Hartl, Sylvia, Forde, Patrick M., Hochmair, Maximilian J., Awad, Mark M., Thomas, Michael, Goss, Glenwood, Wheatley-Price, Paul, Shepherd, Frances A., Florescu, Marie, Cheema, Parneet, Chu, Quincy S. C., Kim, Sang-We, Morgensztern, Daniel, Johnson, Melissa L., Cousin, Sophie, Kim, Dong-Wan, Moskovitz, Mor T., Vicente, David, Aronson, Boaz, Hobson, Rosalind, Ambrose, Helen J., Khosla, Sajan, Reddy, Avinash, Russell, Deanna L., Keddar, Mohamed Reda, Conway, James P., Barrett, J. Carl, Dean, Emma, Kumar, Rakesh, Dressman, Marlene, Jewsbury, Philip J., Iyer, Sonia, Barry, Simon T., Cosaert, Jan, Heymach, John V.

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Abstract B61: The genotype of serous carcinomas shapes the tumor microenvironment and modulates responses to targeted and immune checkpoint therapies von Iyer, Sonia, Zhang, Shuang, Farkkila, Anniina, Smith, Sean, Pepin, David, Mohan, Raghav, Xia, Tian, Reinhardt, Ferenc, Chavarria, Tony, Hoefsmit, Esmee, Poort, Vera, Pathania, Shailja, Zhou, Yunlan, Elias, Kevin M., Hammond, Paula T., Neel, Benjamin G., Weinberg, Robert A.

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Role of SHIP1 in bone biology von Iyer, Sonia, Margulies, Bryan S., Kerr, William G.

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SHIP1-Expressing Mesenchymal Stem Cells Regulate Hematopoietic Stem Cell Homeostasis and Lineage Commitment During Aging von Iyer, Sonia, Brooks, Robert, Gumbleton, Matthew, Kerr, William G.

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Abstract PR1: Development of new immune therapy combinations for ovarian cancer using genetically defined organoid platform von Zhang, Shuang, Iyer, Sonia, Ran, Hao, Wei, Wei, Weinberg, Robert A., Neel, Benjamin G.

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Abstract PR04: The genomic architecture of serous carcinomas shapes the tumor microenvironment and modulates responses to targeted and immunotherapies von Iyer, Sonia, Zhang, Shuang, Farkkila, Anniina, Smith, Sean, Pepin, David, Mohan, Raghav, Reinhardt, Ferenc, Xia, Tian, Chavarria, Tony E., Hoefsmit, Esmee, Pathania, Shailja, Zhou, Yunlan, Elias, Kevin M., Neel, Benjamin G., Weinberg, Robert A.

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SHIP1 Regulates MSC Numbers and Their Osteolineage Commitment by Limiting Induction of the PI3K/Akt/β-Catenin/Id2 Axis von Iyer, Sonia, Viernes, Dennis R., Chisholm, John D., Margulies, Bryan S., Kerr, William G.

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