Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents von Hirai, Hiroshi, Iwasawa, Yoshikazu, Okada, Megumu, Arai, Tsuyoshi, Nishibata, Toshihide, Kobayashi, Makiko, Kimura, Toshifumi, Kaneko, Naoki, Ohtani, Junko, Yamanaka, Kazunori, Itadani, Hiraku, Takahashi-Suzuki, Ikuko, Fukasawa, Kazuhiro, Oki, Hiroko, Nambu, Tadahiro, Jiang, Jian, Sakai, Takumi, Arakawa, Hiroharu, Sakamoto, Toshihiro, Sagara, Takeshi, Yoshizumi, Takashi, Mizuarai, Shinji, Kotani, Hidehito

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p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma von Hideshima, Teru, Cottini, Francesca, Nozawa, Yoshihisa, Seo, Hyuk-Soo, Ohguchi, Hiroto, Samur, Mehmet K., Cirstea, Diana, Mimura, Naoya, Iwasawa, Yoshikazu, Richardson, Paul G., Munshi, Nikhil C., Chauhan, Dharminder, Massefski, Walter, Utsugi, Teruhiro, Dhe-Paganon, Sirano, Anderson, Kenneth C.

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MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel von Shimomura, Toshiyasu, Hasako, Shinichi, Nakatsuru, Yoko, Mita, Takashi, Ichikawa, Koji, Kodera, Tsutomu, Sakai, Takumi, Nambu, Tadahiro, Miyamoto, Mayu, Takahashi, Ikuko, Miki, Satomi, Kawanishi, Nobuhiko, Ohkubo, Mitsuru, Kotani, Hidehito, Iwasawa, Yoshikazu

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Establishment of a human hepatocellular cell line capable of maintaining long-term replication of hepatitis B virus von Yao, Wan-Ling, Ikeda, Sotaro, Tsukamoto, Yuta, Shindo, Keiko, Otakaki, Yukie, Qin, Mian, Iwasawa, Yoshikazu, Takeuchi, Fumihiko, Kaname, Yuki, Chou, Yu-Chi, Chang, Chungming, Watashi, Koichi, Wakita, Takaji, Noda, Takeshi, Kato, Hiroki, Fujita, Takashi

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Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor von Takeuchi, Fumihiko, Ikeda, Sotaro, Tsukamoto, Yuta, Iwasawa, Yoshikazu, Qihao, Chen, Otakaki, Yukie, Ryota, Ouda, Yao, Wan-Ling, Narita, Ryo, Makoto, Hijikata, Watashi, Koichi, Wakita, Takaji, Takeuchi, Koh, Chayama, Kazuaki, Kogure, Amane, Kato, Hiroki, Fujita, Takashi

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Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation von Sunami, Tomoko, Byrne, Noel, Diehl, Ronald E., Funabashi, Kaoru, Hall, Dawn L., Ikuta, Mari, Patel, Sangita B., Shipman, Jennifer M., Smith, Robert F., Takahashi, Ikuko, Zugay-Murphy, Joan, Iwasawa, Yoshikazu, Lumb, Kevin J., Munshi, Sanjeev K., Sharma, Sujata

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Discovery of the First Potent and Selective Small Molecule Opioid Receptor-like (ORL1) Antagonist:  1-[(3R,4R)-1-Cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl- 1,3-dihydro... von Kawamoto, Hiroshi, Ozaki, Satoshi, Itoh, Yoshiki, Miyaji, Mitsuru, Arai, Sachie, Nakashima, Hiroshi, Kato, Tetsuya, Ohta, Hisashi, Iwasawa, Yoshikazu

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Enhanced Spinal Nociceptin Receptor Expression Develops Morphine Tolerance and Dependence von Ueda, Hiroshi, Inoue, Makoto, Takeshima, Hiroshi, Iwasawa, Yoshikazu

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In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist von Ozaki, Satoshi, Kawamoto, Hiroshi, Itoh, Yoshiki, Miyaji, Mitsuru, Azuma, Tomoko, Ichikawa, Daisuke, Nambu, Hirohide, Iguchi, Tomoko, Iwasawa, Yoshikazu, Ohta, Hisashi

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Design, Synthesis, and Discovery of a Novel CCR1 Antagonist von Naya, Akira, Sagara, Yufu, Ohwaki, Kenji, Saeki, Toshihiko, Ichikawa, Daisuke, Iwasawa, Yoshikazu, Noguchi, Kazuhito, Ohtake, Norikazu

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Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo von Hirai, Hiroshi, Shimomura, Toshiyasu, Kobayashi, Makiko, Eguchi, Tomohiro, Taniguchi, Eri, Fukasawa, Kazuhiro, Machida, Takumitsu, Oki, Hiroko, Arai, Tsuyoshi, Ichikawa, Koji, Hasako, Shinichi, Haze, Kyosuke, Kodera, Tsutomu, Kawanishi, Nobuhiko, Takahashi-Suziki, Ikuko, Nakatsuru, Yoko, Kotani, Hidehito, Iwasawa, Yoshikazu

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Abstract P06-02: Discovery of TAS0953/HM06, a novel next generation RET-specific inhibitor capable of inhibiting RET solvent front mutations von Miyazaki, Isao, Ishida, Keiji, Kato, Masanori, Suzuki, Tatsuya, Fujita, Hidenori, Ohkubo, Shuichi, Iwasawa, Yoshikazu

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Efficient and practical asymmetric synthesis of 1- tert-butyl 3-methyl (3 R,4 R)-4-(2-oxo-2,3-dihydro-1 H-benzimidazol-1-yl)piperidine-1,3-dicarboxylate, a useful intermediate for... von Jona, Hideki, Shibata, Jun, Asai, Masanori, Goto, Yasuhiro, Arai, Sachie, Nakajima, Shigeru, Okamoto, Osamu, Kawamoto, Hiroshi, Iwasawa, Yoshikazu

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MK-1775, a small molecule Wee1 inhibitor, enhances anti-tumor efficacy of various DNA-damaging agents, including 5-fluorouracil von Hirai, Hiroshi, Arai, Tsuyoshi, Okada, Megumu, Nishibata, Toshihide, Kobayashi, Makiko, Sakai, Naoko, Imagaki, Kazuhide, Ohtani, Junko, Sakai, Takumi, Yoshizumi, Takashi, Mizuarai, Shinji, Iwasawa, Yoshikazu, Kotani, Hidehito

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TAS3681, a novel type of AR antagonist with AR downregulating activity, as a new targeted therapy for aberrant AR-driven prostate cancer von Seki, Masanao, Minamiguchi, Kazuhisa, Kajiwara, Daisuke, Mizutani, Hiroya, Yoshida, Shohei, Sasaki, Eiji, Utsugi, Teruhiro, Iwasawa, Yoshikazu

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TAS4464, a Novel, Highly Potent NEDD8-Activating Enzyme Inhibitor Shows Antitumor Activity in Ibrutinib-Insensitive Mantle Cell Lymphoma Via Inactivation of the NF-κB Pathway von Muraoka, Hiromi, Yoshimura, Chihoko, Tsuji, Shingo, Hashimoto, Akihiro, Nakagawa, Fumio, Mizutani, Takashi, Ohkubo, Shuichi, Matsuo, Kenichi, Utsugi, Teruhiro, Iwasawa, Yoshikazu

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Abstract B180: TAS-115 attenuates tumor-associated macrophages and enhances sensitivity to anti-PD-1 monoclonal antibody in syngeneic mouse tumors von Haruma, Tomonori, Fujita, Hidenori, Yamada, Yukari, Fukaya, Satoshi, Hashimoto, Akihiro, Harada, Takafumi, Suzuki, Takamasa, Matsuo, Kenichi, Utsugi, Teruhiro, Iwasawa, Yoshikazu

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The impact of TAS3681, a new type of androgen receptor antagonist, on aberrant AR signaling that drives tumor resistance to AR-targeted therapies by down-regulating full length and... von Kajiwara, Daisuke, Minamiguchi, Kazuhisa, Seki, Masanao, Mizutani, Hiroya, Yamamura, Keisuke, Okajima, Shigeo, Sasaki, Eiji, Utsugi, Teruhiro, Iwasawa, Yoshikazu

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Abstract A169: Combination of TPC-144, a reversible LSD1 inhibitor, and a hypomethylating agent resulted in synergistic antitumor efficacy in preclinical models of AML von Osada, Akiko, Kawagishi, Aki, Hatanaka, Ryo, Machida, Takumitsu, Ito, Kenjiro, Yamashita, Satoshi, Ogawa, Takahiro, Imaoka, Tadashi, Matsuo, Kenichi, Utsugi, Teruhiro, Iwasawa, Yoshikazu

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Abstract B136: NEDD8-activating enzyme inhibitor TAS4464 inhibits tumor growth in endometrial cancer mouse model accompanied by DNA damage response von Komiya, Yu, Yoshimura, Chihoko, Muraoka, Hiromi, Ohkubo, Shuichi, Nakagawa, Fumio, Ochiiwa, Hiroaki, Sootome, Hiroshi, Mizutani, Takashi, Matsuo, Kenichi, Utsugi, Teruhiro, Iwasawa, Yoshikazu

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