Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome von Jones, Tiffanie K, Feng, Rui, Kerchberger, V Eric, Reilly, John P, Anderson, Brian J, Shashaty, Michael G S, Wang, Fan, Dunn, Thomas G, Riley, Thomas R, Abbott, Jason, Ittner, Caroline A G, Christiani, David C, Mikacenic, Carmen, Wurfel, Mark M, Ware, Lorraine B, Calfee, Carolyn S, Matthay, Michael A, Christie, Jason D, Meyer, Nuala J

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Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis von Reilly, John P., Wang, Fan, Jones, Tiffanie K., Palakshappa, Jessica A., Anderson, Brian J., Shashaty, Michael G. S., Dunn, Thomas G., Johansson, Erik D., Riley, Thomas R., Lim, Brian, Abbott, Jason, Ittner, Caroline A. G., Cantu, Edward, Lin, Xihong, Mikacenic, Carmen, Wurfel, Mark M., Christiani, David C., Calfee, Carolyn S., Matthay, Michael A., Christie, Jason D., Feng, Rui, Meyer, Nuala J.

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Plasma receptor interacting protein kinase-3 levels are associated with acute respiratory distress syndrome in sepsis and trauma: a cohort study von Shashaty, Michael G S, Reilly, John P, Faust, Hilary E, Forker, Caitlin M, Ittner, Caroline A G, Zhang, Peggy X, Hotz, Meghan J, Fitzgerald, David, Yang, Wei, Anderson, Brian J, Holena, Daniel N, Lanken, Paul N, Christie, Jason D, Meyer, Nuala J, Mangalmurti, Nilam S

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Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study von Miano, Todd A., Hennessy, Sean, Yang, Wei, Dunn, Thomas G., Weisman, Ariel R., Oniyide, Oluwatosin, Agyekum, Roseline S., Turner, Alexandra P., Ittner, Caroline A. G., Anderson, Brian J., Wilson, F. Perry, Townsend, Raymond, Reilly, John P., Giannini, Heather M., Cosgriff, Christopher V., Jones, Tiffanie K., Meyer, Nuala J., Shashaty, Michael G. S.

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Deep learning to detect acute respiratory distress syndrome on chest radiographs: a retrospective study with external validation von Sjoding, Michael W, Taylor, Daniel, Motyka, Jonathan, Lee, Elizabeth, Co, Ivan, Claar, Dru, McSparron, Jakob I, Ansari, Sardar, Kerlin, Meeta Prasad, Reilly, John P, Shashaty, Michael G S, Anderson, Brian J, Jones, Tiffanie K, Drebin, Harrison M, Ittner, Caroline A G, Meyer, Nuala J, Iwashyna, Theodore J, Ward, Kevin R, Gillies, Christopher E

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Patients’ Perspectives on Life and Recovery 1 Year After COVID-19 Hospitalization von Chow, Carolyn P., Chesley, Christopher F., Ward, Michaela, Neergaard, Rebecca, Prasad, Taara V., Dress, Erich M., Reagan, Sara, Kalyani, Priyanka, Smyk, Nathan, Turner, Alexandra P., Agyekum, Roseline S., Ittner, Caroline A. G., Sandsmark, Danielle K., Meyer, Nuala J., Harhay, Michael O., Kohn, Rachel, Auriemma, Catherine L.

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Constant mineralization density distribution in cancellous human bone von Roschger, P, Gupta, H.S, Berzlanovich, A, Ittner, G, Dempster, D.W, Fratzl, P, Cosman, F, Parisien, M, Lindsay, R, Nieves, J.W, Klaushofer, K

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Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19 von Apostolidis, Sokratis A, Sarkar, Amrita, Giannini, Heather M, Goel, Rishi R, Mathew, Divij, Suzuki, Aae, Baxter, Amy E, Greenplate, Allison R, Alanio, Cécile, Abdel-Hakeem, Mohamed, Oldridge, Derek A, Giles, Josephine R, Wu, Jennifer E, Chen, Zeyu, Huang, Yinghui Jane, Belman, Jonathan, Pattekar, Ajinkya, Manne, Sasikanth, Kuthuru, Oliva, Dougherty, Jeanette, Weiderhold, Brittany, Weisman, Ariel R, Ittner, Caroline A G, Gouma, Sigrid, Dunbar, Debora, Frank, Ian, Huang, Alexander C, Vella, Laura A, Reilly, John P, Hensley, Scott E, Rauova, Lubica, Zhao, Liang, Meyer, Nuala J, Poncz, Mortimer, Abrams, Charles S, Wherry, E John

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Sepsis-associated acute respiratory distress syndrome in individuals of European ancestry: a genome-wide association study von Guillen-Guio, Beatriz, Lorenzo-Salazar, Jose M, Ma, Shwu-Fan, Hou, Pei-Chi, Hernandez-Beeftink, Tamara, Corrales, Almudena, García-Laorden, M Isabel, Jou, Jonathan, Espinosa, Elena, Muriel, Arturo, Domínguez, David, Lorente, Leonardo, Martín, María M, Rodríguez-Gallego, Carlos, Solé-Violán, Jordi, Ambrós, Alfonso, Carriedo, Demetrio, Blanco, Jesús, Añón, José M, Reilly, John P, Jones, Tiffanie K, Ittner, Caroline AG, Feng, Rui, Schöneweck, Franziska, Kiehntopf, Michael, Noth, Imre, Scholz, Markus, Brunkhorst, Frank M, Scherag, André, Meyer, Nuala J, Villar, Jesús, Flores, Carlos

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Low Plasma Levels of Adiponectin Do Not Explain Acute Respiratory Distress Syndrome Risk: a Prospective Cohort Study of Patients with Severe Sepsis von Palakshappa, Jessica A, Anderson, Brian J, Reilly, John P, Shashaty, Michael G S, Ueno, Ryo, Wu, Qufei, Ittner, Caroline A G, Tommasini, Anna, Dunn, Thomas G, Charles, Dudley, Kazi, Altaf, Christie, Jason D, Meyer, Nuala J

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Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients von Faust, Hilary E., Reilly, John P., Anderson, Brian J., Ittner, Caroline A.G., Forker, Caitlyn M., Zhang, Peggy, Weaver, Benjamin A., Holena, Daniel N., Lanken, Paul N., Christie, Jason D., Meyer, Nuala J., Mangalmurti, Nilam S., Shashaty, Michael G.S.

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Elevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate With Organ Dysfunction and Mortality in Sepsis von Jones, Tiffanie K., Reilly, John P., Anderson, Brian J., Miano, Todd A., Dunn, Thomas G., Weisman, Ariel R., Agyekum, Roseline, Feng, Rui, Ittner, Caroline A.G., Shashaty, Michael G.S., Meyer, Nuala J.

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Erythrocytes identify complement activation in patients with COVID-19 von Lam, L K Metthew, Reilly, John P, Rux, Ann H, Murphy, Sophia J, Kuri-Cervantes, Leticia, Weisman, Ariel R, Ittner, Caroline A G, Pampena, M Betina, Betts, Michael R, Wherry, E John, Song, Wen-Chao, Lambris, John D, Meyer, Nuala J, Cines, Douglas B, Mangalmurti, Nilam S

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Acute Respiratory Distress Syndrome Mediates the Association between Early Plasma Soluble Receptor for Advanced Glycation End Products Concentrations and Mortality in Sepsis von Jones, Tiffanie K, Reilly, John P, Anderson, Brian J, Miano, Todd A, Dunn, Thomas G, Turner, Alexandra P, Agyekum, Roseline S, Feng, Rui, Ittner, Caroline A G, Shashaty, Michael G S, Meyer, Nuala J

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ABO Histo-Blood Group and the von Willebrand Factor Axis in Severe COVID-19 von Reilly, John P., Shashaty, Michael G.S., Miano, Todd A., Giannini, Heather M., Jones, Tiffanie K., Ittner, Caroline A.G., Christie, Jason D., Meyer, Nuala J.

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CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer von Bange, Erin M., Han, Nicholas A., Wileyto, Paul, Kim, Justin Y., Gouma, Sigrid, Robinson, James, Greenplate, Allison R., Hwee, Madeline A., Porterfield, Florence, Owoyemi, Olutosin, Naik, Karan, Zheng, Cathy, Galantino, Michael, Weisman, Ariel R., Ittner, Caroline A. G., Kugler, Emily M., Baxter, Amy E., Oniyide, Olutwatosin, Agyekum, Roseline S., Dunn, Thomas G., Jones, Tiffanie K., Giannini, Heather M., Weirick, Madison E., McAllister, Christopher M., Babady, N. Esther, Kumar, Anita, Widman, Adam J., DeWolf, Susan, Boutemine, Sawsan R., Roberts, Charlotte, Budzik, Krista R., Tollett, Susan, Wright, Carla, Perloff, Tara, Sun, Lova, Mathew, Divij, Giles, Josephine R., Oldridge, Derek A., Wu, Jennifer E., Alanio, Cécile, Adamski, Sharon, Garfall, Alfred L., Vella, Laura A., Kerr, Samuel J., Cohen, Justine V., Oyer, Randall A., Massa, Ryan, Maillard, Ivan P., Maxwell, Kara N., Reilly, John P., Maslak, Peter G., Vonderheide, Robert H., Wolchok, Jedd D., Hensley, Scott E., Wherry, E. John, Meyer, Nuala J., DeMichele, Angela M., Vardhana, Santosha A., Mamtani, Ronac, Huang, Alexander C.

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Cytometry masked autoencoder: An accurate and interpretable automated immunophenotyper von Kim, Jaesik, Ionita, Matei, Lee, Matthew, McKeague, Michelle L., Pattekar, Ajinkya, Painter, Mark M., Wagenaar, Joost, Truong, Van, Norton, Dylan T., Mathew, Divij, Nam, Yonghyun, Apostolidis, Sokratis A., Clendenin, Cynthia, Orzechowski, Patryk, Jung, Sang-Hyuk, Woerner, Jakob, Ittner, Caroline A.G., Turner, Alexandra P., Esperanza, Mika, Dunn, Thomas G., Mangalmurti, Nilam S., Reilly, John P., Meyer, Nuala J., Calfee, Carolyn S., Liu, Kathleen D., Matthy, Michael A., Swigart, Lamorna Brown, Burnham, Ellen L., McKeehan, Jeffrey, Gandotra, Sheetal, Russel, Derek W., Gibbs, Kevin W., Thomas, Karl W., Barot, Harsh, Greenplate, Allison R., Wherry, E. John, Kim, Dokyoon

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Validating a Proteomic Signature of Severe COVID-19 von Cosgriff, Christopher V, Miano, Todd A, Mathew, Divij, Huang, Alexander C, Giannini, Heather M, Kuri-Cervantes, Leticia, Pampena, M Betina, Ittner, Caroline A G, Weisman, Ariel R, Agyekum, Roseline S, Dunn, Thomas G, Oniyide, Oluwatosin, Turner, Alexandra P, D'Andrea, Kurt, Adamski, Sharon, Greenplate, Allison R, Anderson, Brian J, Harhay, Michael O, Jones, Tiffanie K, Reilly, John P, Mangalmurti, Nilam S, Shashaty, Michael G S, Betts, Michael R, Wherry, E John, Meyer, Nuala J

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D93 RESPIRATORY FAILURE: ADVANCED MECHANISTIC INSIGHTS INFORMING TRANSLATION IN ACUTE LUNG INJURY/ARDS: Abo Genetic Variation And Acute Respiratory Distress Syndrome Risk In Sepsis von Reilly, J P, Meyer, N J, Shashaty, M G S, Anderson, B J, Palakshappa, J A, G Ittner, C A, Calfee, C S, Matthay, M, Wang, Z, Mikacenic, C, Lin, X, Barnett, I, Walley, K, Russell, J A, Christiani, D C, Wurfel, M M, Christie, J D

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Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial von Alipanah-Lechner, Narges, Hurst-Hopf, James, Delucchi, Kevin, Swigart, Lamorna, Willmore, Andrew, LaCombe, Benjamin, Dewar, Robin, Lane, H Clifford, Lallemand, Perrine, Liu, Kathleen D, Esserman, Laura, Matthay, Michael A, Calfee, Carolyn S

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