Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets von Ohta, Atsushi, Tanada, Mikimasa, Shinohara, Shojiro, Morita, Yuya, Nakano, Kazuhiko, Yamagishi, Yusuke, Takano, Ryusuke, Kariyuki, Shiori, Iida, Takeo, Matsuo, Atsushi, Ozeki, Kazuhisa, Emura, Takashi, Sakurai, Yuuji, Takano, Koji, Higashida, Atsuko, Kojima, Miki, Muraoka, Terushige, Takeyama, Ryuuichi, Kato, Tatsuya, Kimura, Kaori, Ogawa, Kotaro, Ohara, Kazuhiro, Tanaka, Shota, Kikuchi, Yasufumi, Hisada, Nozomi, Hayashi, Ryuji, Nishimura, Yoshikazu, Nomura, Kenichi, Tachibana, Tatsuhiko, Irie, Machiko, Kawada, Hatsuo, Torizawa, Takuya, Murao, Naoaki, Kotake, Tomoya, Tanaka, Masahiko, Ishikawa, Shiho, Miyake, Taiji, Tamiya, Minoru, Arai, Masako, Chiyoda, Aya, Akai, Sho, Sase, Hitoshi, Kuramoto, Shino, Ito, Toshiya, Shiraishi, Takuya, Kojima, Tetsuo, Iikura, Hitoshi

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Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802) von Kinoshita, Kazutomo, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Miyagi, Takuho, Kobayashi, Takamitsu, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Structural and functional characterization of aspartate racemase from the acidothermophilic archaeon Picrophilus torridus von Aihara, Takayuki, Ito, Toshiya, Yamanaka, Yasuaki, Noguchi, Keiichi, Odaka, Masafumi, Sekine, Masae, Homma, Hiroshi, Yohda, Masafumi

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Enantioselective Total Synthesis of (−)-Erinacine B von Watanabe, Hideaki, Takano, Masashi, Umino, Akinori, Ito, Toshiya, Ishikawa, Hiroyuki, Nakada, Masahisa

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Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor von Ito, Toshiya, Kinoshita, Kazutomo, Tomizawa, Masaki, Shinohara, Shojiro, Nishii, Hiroki, Matsushita, Masayuki, Hattori, Kazuo, Kohchi, Yasunori, Kohchi, Masami, Hayase, Tadakatsu, Watanabe, Fumio, Hasegawa, Kiyoshi, Tanaka, Hiroshi, Kuramoto, Shino, Takanashi, Kenji, Oikawa, Nobuhiro

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Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display von Kage, Mirai, Hayashi, Ryuji, Matsuo, Atsushi, Tamiya, Minoru, Kuramoto, Shino, Ohara, Kazuhiro, Irie, Machiko, Chiyoda, Aya, Takano, Koji, Ito, Toshiya, Kotake, Tomoya, Takeyama, Ryuuichi, Ishikawa, Shiho, Nomura, Kenichi, Furuichi, Noriyuki, Morita, Yuya, Hashimoto, Satoshi, Kawada, Hatsuo, Nishimura, Yoshikazu, Nii, Keiji, Sase, Hitoshi, Ohta, Atsushi, Kojima, Tetsuo, Iikura, Hitoshi, Tanada, Mikimasa, Shiraishi, Takuya

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Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core von Oki, Tomohiro, Tsukazaki, Masao, Shiina, Junichi, Fukuda, Hiroshi, Yamawaki, Minoru, Kito, Yasushi, Ishizawa, Takenori, Kinoshita, Kazutomo, Hara, Sosuke, Furuichi, Noriyuki, Kawada, Hatsuo, Ito, Toshiya, Tanaka, Kota, Maruyama, Noriaki, Tamaru, Daisuke, Ichige, Takahiro, Koizumi, Masatoshi, Hosoya, Yosuke, Kimura, Masahiro, Yamaguchi, Mami, Sato, Shigeki, Miyazaki, Yuta, Toya, Azusa, Iwamura, Hiroshi, Maeda, Kenji

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Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor von Tanada, Mikimasa, Tamiya, Minoru, Matsuo, Atsushi, Chiyoda, Aya, Takano, Koji, Ito, Toshiya, Irie, Machiko, Kotake, Tomoya, Takeyama, Ryuuichi, Kawada, Hatsuo, Hayashi, Ryuji, Ishikawa, Shiho, Nomura, Kenichi, Furuichi, Noriyuki, Morita, Yuya, Kage, Mirai, Hashimoto, Satoshi, Nii, Keiji, Sase, Hitoshi, Ohara, Kazuhiro, Ohta, Atsushi, Kuramoto, Shino, Nishimura, Yoshikazu, Iikura, Hitoshi, Shiraishi, Takuya

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9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors von Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Correction to Enantioselective Total Synthesis of (−)-Erinacine B von Watanabe, Hideaki, Takano, Masashi, Umino, Akinori, Ito, Toshiya, Ishikawa, Hiroyuki, Nakada, Masahisa

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Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors von Kinoshita, Kazutomo, Ono, Yoshiyuki, Emura, Takashi, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Tanaka, Shota, Morikami, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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Penetration of Oral Fluconazole into Gynecological Tissues von MIKAMO, H, KAWAZOE, K, SATO, Y, IZUMI, K, ITO, T, ITO, K, TAMAYA, T

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Vehicle camera device von Ito, Toshiya, Sadamatsu, Ryusuke

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VIEWING DEVICE FOR VEHICLE von ITO, Toshiya, SADAMATSU, Ryusuke

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VEHICLE CAMERA DEVICE von ITO, Toshiya, SADAMATSU, Ryusuke

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9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5 H -benzo[ b ]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors von Kinoshita, Kazutomo, Kobayashi, Takamitsu, Asoh, Kohsuke, Furuichi, Noriyuki, Ito, Toshiya, Kawada, Hatsuo, Hara, Sousuke, Ohwada, Jun, Hattori, Kazuo, Miyagi, Takuho, Hong, Woo-Sang, Park, Min-Jeong, Takanashi, Kenji, Tsukaguchi, Toshiyuki, Sakamoto, Hiroshi, Tsukuda, Takuo, Oikawa, Nobuhiro

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von Recklinghausen's Disease Complicated by Gastric Diffuse Ganglioneuromatosis and Early Gastric Cancer: A Case Report von Yamaie, Hitoshi, Ito, Toshiya, Ishizu, Kaname, Kitaoka, Fumio, Aoki, Koichi, Ohtani, Hiroshi

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Plating method von Ito, Toshiya, Ohnishi, Masaru

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Installation Apparatus von ITO, Toshiya, SADAMATSU, Ryusuke, IWATSUKI, Masakazu

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VISUAL RECOGNITION DEVICE FOR VEHICLE von ITO, Toshiya, YOKOYAMA, Kazuyuki

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